DegronMD

Uniprot ID: Q86VP3

Source protein: Phosphofurin acidic cluster sorting protein 2

Source gene: PACS2

Class: DEG_SPOP_SBC_1

Location: 240:244

E3 ligase: SPOP

DEGRON score: 0.9252

ASA_SCORE: 95.22

COIL: 0.7852

CONS_SCORE: 0.3018

DSS_SCORE: 0.5514

HELIX: 0.1888

FCONS_SCORE: 0.6077

RIG_SCORE: 0.7684

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S238L	TCGA-90-A4ED	LUSC	TCGA	VRTTS	DEG_SPOP_SBC_1	0.7222
p.S238L	TCGA-D3-A8GM	SKCM	TCGA	VRTTS	DEG_SPOP_SBC_1	0.7222
p.S238L	TCGA-EO-A3B0	UCEC	TCGA	VRTTS	DEG_SPOP_SBC_1	0.7222
p.R237I	TCGA-AX-A2HC	UCEC	TCGA	VRTTS	DEG_SPOP_SBC_1	0.25
p.T242M	TCGA-EO-A3B0	UCEC	TCGA	VRTTS	DEG_SPOP_SBC_1	0.7423
p.T242M	TCGA-EY-A549	UCEC	TCGA	VRTTS	DEG_SPOP_SBC_1	0.7423
p.T246I	TCGA-FI-A2D0	UCEC	TCGA	VRTTS	DEG_SPOP_SBC_1	0.7222
p.N250Y	TCGA-FP-8099	STAD	TCGA	VRTTS	DEG_SPOP_SBC_1	0.1667
p.R236W	TCGA-VQ-A8P2	STAD	TCGA	VRTTS	DEG_SPOP_SBC_1	0.2222
p.E253K	DO51865	BLCA	ICGC	VRTTS	DEG_SPOP_SBC_1	0.0833
p.S241L	DO1555	BRCA	ICGC	VRTTS	DEG_SPOP_SBC_1	0.7667
p.G245E	DO2401	BRCA	ICGC	VRTTS	DEG_SPOP_SBC_1	0.3056
p.V234M	DO234377	ESAD	ICGC	VRTTS	DEG_SPOP_SBC_1	0.2778
p.H248Y	DO19663	KIRC	ICGC	VRTTS	DEG_SPOP_SBC_1	0.2222
p.H248Y	CAL-62	thyroid	COSMIC	VRTTS	DEG_SPOP_SBC_1	0.2222
p.A233S	DO228976	LICA	ICGC	VRTTS	DEG_SPOP_SBC_1	0.25
p.A230S	DO228976	LICA	ICGC	VRTTS	DEG_SPOP_SBC_1	0.0556
p.Q252H	DO229026	LICA	ICGC	VRTTS	DEG_SPOP_SBC_1	0.2222
p.G245R	DO22986	LIHC	ICGC	VRTTS	DEG_SPOP_SBC_1	0.3056
p.S249F	DO222434	MELA	ICGC	VRTTS	DEG_SPOP_SBC_1	0.1944
p.F232V	DO50083	OV	ICGC	VRTTS	DEG_SPOP_SBC_1	0.1111
p.S249P	DO218878	SKCA	ICGC	VRTTS	DEG_SPOP_SBC_1	0.1944
p.P250S	DO37406	SKCM	ICGC	VRTTS	DEG_SPOP_SBC_1	0.1667
p.R230Q	DO41999	UCEC	ICGC	VRTTS	DEG_SPOP_SBC_1	0.0556
p.P250L	IGR-1	skin	COSMIC	VRTTS	DEG_SPOP_SBC_1	0.1667
p.D236E	SUP-B8	haematopoietic_and_lymphoid_tissue	COSMIC	VRTTS	DEG_SPOP_SBC_1	0.2222
p.D236E	NCI-H2066	lung	COSMIC	VRTTS	DEG_SPOP_SBC_1	0.2222
p.Q243K	KARPAS-620	haematopoietic_and_lymphoid_tissue	COSMIC	VRTTS	DEG_SPOP_SBC_1	0.6944
p.S252W	HT	haematopoietic_and_lymphoid_tissue	COSMIC	VRTTS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95819	Mitogen-activated protein kinase kinase kinase kinase 4	DEG_SPOP_SBC_1	625:629	VRTTS	SPOP	0.9834	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7603:7607	VRTTS	SPOP	0.8942	More...
Q86VP3	Phosphofurin acidic cluster sorting protein 2	DEG_SPOP_SBC_1	240:244	VRTTS	SPOP	0.9252	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VRTTS

Degron related mutations and impact score

Drug responses associated with PACS2 mutations

All proteins holding degron of VRTTS