DegronMD - Q9UPS6(SETD1B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D1221N	TCGA-5M-AAT6	COAD	TCGA	LAPGAPAVDSLGM	DEG_ODPH_VHL_1	1218:1230	Mutation altering degron motif	0.6932
p.A1220V	TCGA-AA-3864	COAD	TCGA	LAPGAPAVDSLGM	DEG_ODPH_VHL_1	1218:1230	Mutation altering degron motif	0.6936
p.A1220V	ACH-000969	Colon/Colorectal Cancer	CCLE	LAPGAPAVDSLGM	DEG_ODPH_VHL_1	1218:1230	Mutation altering degron motif	0.6936
p.R555Q	TCGA-AP-A1DK	UCEC	TCGA	PTPPSS	DEG_SCF_FBW7_1	557:562	Mutation rewiring degron network	0.2778
p.R555Q	DO42033	UCEC	ICGC	PTPPSS	DEG_SCF_FBW7_1	557:562	Mutation rewiring degron network	0.2778
p.S522L	TCGA-AZ-6598	COAD	TCGA	PISSS	DEG_SPOP_SBC_1	532:536	Mutation rewiring degron network	0.0556
p.S522L	DO10276	COAD	ICGC	PISSS	DEG_SPOP_SBC_1	532:536	Mutation rewiring degron network	0.0556
p.A544T	TCGA-B5-A1MR	UCEC	TCGA	PISSS	DEG_SPOP_SBC_1	532:536	Mutation rewiring degron network	0.1111
p.A544T	DO41758	UCEC	ICGC	PISSS	DEG_SPOP_SBC_1	532:536	Mutation rewiring degron network	0.1111
p.E1049K	TCGA-B5-A1MU	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	1049:1053	Mutation altering degron motif	0.7022
p.E1049K	ACH-001864	Bile Duct Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	1049:1053	Mutation altering degron motif	0.7022
p.S843L	TCGA-CK-4951	COAD	TCGA	PPGY	ITCH	846:849	Mutation rewiring degron network	0.25
p.S843L	DO10582	COAD	ICGC	PPGY	ITCH	846:849	Mutation rewiring degron network	0.25
p.L981M	TCGA-D1-A15X	UCEC	TCGA	PDTTS	DEG_SPOP_SBC_1	970:974	Mutation rewiring degron network	0.1389
p.L981M	DO43274	UCEC	ICGC	PDTTS	DEG_SPOP_SBC_1	970:974	Mutation rewiring degron network	0.1389
p.D920G	TCGA-EO-A22R	UCEC	TCGA	LTPVKS	DEG_SCF_FBW7_1	908:913	Mutation rewiring degron network	0.1389
p.D920G	DO42713	UCEC	ICGC	LTPVKS	DEG_SCF_FBW7_1	908:913	Mutation rewiring degron network	0.1389
p.E1155K	TCGA-GM-A2DI	BRCA	TCGA	ATSSS	DEG_SPOP_SBC_1	1152:1156	Mutation altering degron motif	0.7022
p.E1155K	DMS-273	lung	COSMIC	ATSSS	DEG_SPOP_SBC_1	1152:1156	Mutation altering degron motif	0.7022
p.A1369S	TCGA-KO-8415	KICH	TCGA	VPATPGGE	DEG_SCF_FBW7_2	1379:1386	Mutation rewiring degron network	0.0556
p.R902W	TCGA-OR-A5J5	ACC	TCGA	LTPVKS	DEG_SCF_FBW7_1	908:913	Mutation rewiring degron network	0.1667
p.E1057K	TCGA-VS-A94W	CESC	TCGA	ASSSS	DEG_SPOP_SBC_1	1049:1053	Mutation rewiring degron network	0.2222
p.P1223H	DO219728	CESC	ICGC	LAPGAPAVDSLGM	DEG_ODPH_VHL_1	1218:1230	Mutation altering degron motif	0.6583
p.P842L	DO217822	GACA	ICGC	PPGY	ITCH	846:849	Mutation rewiring degron network	0.2222
p.E1237K	DO233115	GACA	ICGC	LAPGAPAVDSLGM	DEG_ODPH_VHL_1	1218:1230	Mutation rewiring degron network	0.1389
p.M850I	DO228974	LICA	ICGC	PPGY	ITCH	846:849	Mutation rewiring degron network	0.3056
p.D1235Y	DO229038	LICA	ICGC	LAPGAPAVDSLGM	DEG_ODPH_VHL_1	1218:1230	Mutation rewiring degron network	0.1944
p.I572V	DO23188	LINC	ICGC	PTPPSS	DEG_SCF_FBW7_1	557:562	Mutation rewiring degron network	0.0556
p.I572V	ACH-000831	Endometrial/Uterine Cancer	CCLE	PTPPSS	DEG_SCF_FBW7_1	557:562	Mutation rewiring degron network	0.0556
p.P970L	DO230974	LUSC	ICGC	PDTTS	DEG_SPOP_SBC_1	970:974	Mutation altering degron motif	0.7582
p.P970L	DO224632	LUSC	ICGC	PDTTS	DEG_SPOP_SBC_1	970:974	Mutation altering degron motif	0.7582
p.A1371V	DO220886	MELA	ICGC	VPATPGGE	DEG_SCF_FBW7_2	1379:1386	Mutation rewiring degron network	0.1111
p.P960L	DO220912	MELA	ICGC	PDTTS	DEG_SPOP_SBC_1	970:974	Mutation rewiring degron network	0.0556
p.A1152T	DO36400	READ	ICGC	ATSSS	DEG_SPOP_SBC_1	1152:1156	Mutation altering degron motif	0.7139
p.S961F	DO229470	SKCA	ICGC	PDTTS	DEG_SPOP_SBC_1	970:974	Mutation blocking phosphorylation signal	0.5278
p.Q1374R	DO42023	UCEC	ICGC	VPATPGGE	DEG_SCF_FBW7_2	1379:1386	Mutation rewiring degron network	0.1944
p.T1153M	DO42568	UCEC	ICGC	ATSSS	DEG_SPOP_SBC_1	1152:1156	Mutation altering degron motif	0.6312
p.D977N	SIDM02049	Pancreatic Carcinoma	GDSC	PDTTS	DEG_SPOP_SBC_1	970:974	Mutation rewiring degron network	0.25
p.G1384R	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	VPATPGGE	DEG_SCF_FBW7_2	1379:1386	Mutation altering degron motif	0.6457
p.G1384R	SIDM01178	Other Solid Cancers	GDSC	VPATPGGE	DEG_SCF_FBW7_2	1379:1386	Mutation altering degron motif	0.6457
p.G1384R	SIDM00671	T-Cell Non-Hodgkin's Lymphoma	GDSC	VPATPGGE	DEG_SCF_FBW7_2	1379:1386	Mutation altering degron motif	0.6457
p.G1384R	SIDM00820	Kidney Carcinoma	GDSC	VPATPGGE	DEG_SCF_FBW7_2	1379:1386	Mutation altering degron motif	0.6457
p.G1384R	SIDM00520	Mesothelioma	GDSC	VPATPGGE	DEG_SCF_FBW7_2	1379:1386	Mutation altering degron motif	0.6457
p.G1384R	SIDM01063	Acute Myeloid Leukemia	GDSC	VPATPGGE	DEG_SCF_FBW7_2	1379:1386	Mutation altering degron motif	0.6457
p.G1384R	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	VPATPGGE	DEG_SCF_FBW7_2	1379:1386	Mutation altering degron motif	0.6457
p.G1384R	SIDM01102	Non-Cancerous	GDSC	VPATPGGE	DEG_SCF_FBW7_2	1379:1386	Mutation altering degron motif	0.6457
p.D977E	ACH-000331	Lung Cancer	CCLE	PDTTS	DEG_SPOP_SBC_1	970:974	Mutation rewiring degron network	0.25
p.T484R	ACH-000395	Lung Cancer	CCLE	PGTPTLE	DEG_SCF_FBW7_2	480:486	Mutation altering degron motif	0.6765
p.S1050L	ACH-000411	Kidney Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	1049:1053	Mutation altering degron motif	0.6556
p.A1054V	ACH-000659	Lung Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	1049:1053	Mutation rewiring degron network	0.3056
p.A1054V	ACH-001386	Lung Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	1049:1053	Mutation rewiring degron network	0.3056
p.T482M	ACH-000790	Lung Cancer	CCLE	PGTPTLE	DEG_SCF_FBW7_2	480:486	Mutation altering degron motif	0.7423
p.T482M	ACH-001333	Cervical Cancer	CCLE	PGTPTLE	DEG_SCF_FBW7_2	480:486	Mutation altering degron motif	0.7423
p.S975F	ACH-000808	Bile Duct Cancer	CCLE	PDTTS	DEG_SPOP_SBC_1	970:974	Mutation blocking phosphorylation signal	0.75
p.S550F	ACH-000931	Skin Cancer	CCLE	PTPPSS	DEG_SCF_FBW7_1	557:562	Mutation rewiring degron network	0.1389
p.S1393R	ACH-000964	Leukemia	CCLE	VPATPGGE	DEG_SCF_FBW7_2	1379:1386	Mutation rewiring degron network	0.1389
p.R563H	ACH-000986	Colon/Colorectal Cancer	CCLE	PTPPSS	DEG_SCF_FBW7_1	557:562	Mutation rewiring degron network	0.3056
p.R563H	ACH-000990	Endometrial/Uterine Cancer	CCLE	PTPPSS	DEG_SCF_FBW7_1	557:562	Mutation rewiring degron network	0.3056
p.R980W	ACH-001333	Cervical Cancer	CCLE	PDTTS	DEG_SPOP_SBC_1	970:974	Mutation rewiring degron network	0.1667
p.P1372S	HEC-1	endometrium	COSMIC	VPATPGGE	DEG_SCF_FBW7_2	1379:1386	Mutation substituting flanking lysine	0.25
p.E1151D	LK-2	lung	COSMIC	ATSSS	DEG_SPOP_SBC_1	1152:1156	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SETD1B

UniProt ID: Q9UPS6

Entrez ID: 23067

Protein name: Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SETD1B in