DegronMD

Uniprot ID: Q9UPS6

Source protein: Histone-lysine N-methyltransferase SETD1B

Source gene: SETD1B

Class: DEG_ODPH_VHL_1

Location: 1218:1230

E3 ligase: VHL

DEGRON score: 0.5807

ASA_SCORE: 73.5538

COIL: 0.8041

CONS_SCORE: 0.2451

DSS_SCORE: 0.7134

HELIX: 0.136

FCONS_SCORE: 0.9442

RIG_SCORE: 0.6552

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1221N	TCGA-5M-AAT6	COAD	TCGA	LAPGAPAVDSLGM	DEG_ODPH_VHL_1	0.6932
p.A1220V	TCGA-AA-3864	COAD	TCGA	LAPGAPAVDSLGM	DEG_ODPH_VHL_1	0.6936
p.A1220V	ACH-000969	Colon/Colorectal Cancer	CCLE	LAPGAPAVDSLGM	DEG_ODPH_VHL_1	0.6936
p.P1223H	DO219728	CESC	ICGC	LAPGAPAVDSLGM	DEG_ODPH_VHL_1	0.6583
p.E1237K	DO233115	GACA	ICGC	LAPGAPAVDSLGM	DEG_ODPH_VHL_1	0.1389
p.D1235Y	DO229038	LICA	ICGC	LAPGAPAVDSLGM	DEG_ODPH_VHL_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPS6	Histone-lysine N-methyltransferase SETD1B	DEG_ODPH_VHL_1	1218:1230	LAPGAPAVDSLGM	VHL	0.5807	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons