DegronMD

Uniprot ID: Q9UPS6

Source protein: Histone-lysine N-methyltransferase SETD1B

Source gene: SETD1B

Class: DEG_SCF_FBW7_1

Location: 908:913

E3 ligase: FBXW7

DEGRON score: 0.9269

ASA_SCORE: 93.1667

COIL: 0.9197

CONS_SCORE: 0.2977

DSS_SCORE: 0.5379

HELIX: 0.0368

FCONS_SCORE: 0.9149

RIG_SCORE: 0.6632

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D920G	TCGA-EO-A22R	UCEC	TCGA	LTPVKS	DEG_SCF_FBW7_1	0.1389
p.D920G	DO42713	UCEC	ICGC	LTPVKS	DEG_SCF_FBW7_1	0.1389
p.R902W	TCGA-OR-A5J5	ACC	TCGA	LTPVKS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPS6	Histone-lysine N-methyltransferase SETD1B	DEG_SCF_FBW7_1	908:913	LTPVKS	FBXW7	0.9269	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons