DegronMD

Uniprot ID: Q9UPS6

Source protein: Histone-lysine N-methyltransferase SETD1B

Source gene: SETD1B

Class: DEG_SCF_FBW7_2

Location: 1379:1386

E3 ligase: FBXW7

DEGRON score: 0.9969

ASA_SCORE: 70.5875

COIL: 0.9434

CONS_SCORE: 0.3081

DSS_SCORE: 0.7693

HELIX: 0.0133

FCONS_SCORE: 1.0818

RIG_SCORE: 0.5827

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1369S	TCGA-KO-8415	KICH	TCGA	VPATPGGE	DEG_SCF_FBW7_2	0.0556
p.A1371V	DO220886	MELA	ICGC	VPATPGGE	DEG_SCF_FBW7_2	0.1111
p.Q1374R	DO42023	UCEC	ICGC	VPATPGGE	DEG_SCF_FBW7_2	0.1944
p.G1384R	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	VPATPGGE	DEG_SCF_FBW7_2	0.6457
p.G1384R	SIDM01178	Other Solid Cancers	GDSC	VPATPGGE	DEG_SCF_FBW7_2	0.6457
p.G1384R	SIDM00671	T-Cell Non-Hodgkin's Lymphoma	GDSC	VPATPGGE	DEG_SCF_FBW7_2	0.6457
p.G1384R	SIDM00820	Kidney Carcinoma	GDSC	VPATPGGE	DEG_SCF_FBW7_2	0.6457
p.G1384R	SIDM00520	Mesothelioma	GDSC	VPATPGGE	DEG_SCF_FBW7_2	0.6457
p.G1384R	SIDM01063	Acute Myeloid Leukemia	GDSC	VPATPGGE	DEG_SCF_FBW7_2	0.6457
p.G1384R	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	VPATPGGE	DEG_SCF_FBW7_2	0.6457
p.G1384R	SIDM01102	Non-Cancerous	GDSC	VPATPGGE	DEG_SCF_FBW7_2	0.6457
p.S1393R	ACH-000964	Leukemia	CCLE	VPATPGGE	DEG_SCF_FBW7_2	0.1389
p.P1372S	HEC-1	endometrium	COSMIC	VPATPGGE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPS6	Histone-lysine N-methyltransferase SETD1B	DEG_SCF_FBW7_2	1379:1386	VPATPGGE	FBXW7	0.9969	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons