DegronMD

Uniprot ID: Q9UPS6

Source protein: Histone-lysine N-methyltransferase SETD1B

Source gene: SETD1B

Class: DEG_SPOP_SBC_1

Location: 970:974

E3 ligase: SPOP

DEGRON score: 0.5641

ASA_SCORE: 95.5

COIL: 0.9488

CONS_SCORE: 0.2963

DSS_SCORE: 0.7149

HELIX: 0.0258

FCONS_SCORE: 0.7832

RIG_SCORE: 0.587

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L981M	TCGA-D1-A15X	UCEC	TCGA	PDTTS	DEG_SPOP_SBC_1	0.1389
p.L981M	DO43274	UCEC	ICGC	PDTTS	DEG_SPOP_SBC_1	0.1389
p.P970L	DO230974	LUSC	ICGC	PDTTS	DEG_SPOP_SBC_1	0.7582
p.P970L	DO224632	LUSC	ICGC	PDTTS	DEG_SPOP_SBC_1	0.7582
p.P960L	DO220912	MELA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.0556
p.S961F	DO229470	SKCA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.5278
p.D977N	SIDM02049	Pancreatic Carcinoma	GDSC	PDTTS	DEG_SPOP_SBC_1	0.25
p.D977E	ACH-000331	Lung Cancer	CCLE	PDTTS	DEG_SPOP_SBC_1	0.25
p.S975F	ACH-000808	Bile Duct Cancer	CCLE	PDTTS	DEG_SPOP_SBC_1	0.75
p.R980W	ACH-001333	Cervical Cancer	CCLE	PDTTS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P01042	Kininogen-1	DEG_SPOP_SBC_1	607:611	PDTTS	SPOP	0.9956	More...
Q00536	Cyclin-dependent kinase 16	DEG_SPOP_SBC_1	457:461	PDTTS	SPOP	0.5081	More...
Q0VDD7	Break repair meiotic recombinase recruitment factor 1	DEG_SPOP_SBC_1	503:507	PDTTS	SPOP	0.9727	More...
Q13477	Mucosal addressin cell adhesion molecule 1	DEG_SPOP_SBC_1	233:237	PDTTS	SPOP	0.7817	More...
Q13477	Mucosal addressin cell adhesion molecule 1	DEG_SPOP_SBC_1	241:245	PDTTS	SPOP	0.9214	More...
Q13477	Mucosal addressin cell adhesion molecule 1	DEG_SPOP_SBC_1	249:253	PDTTS	SPOP	0.8155	More...
Q13477	Mucosal addressin cell adhesion molecule 1	DEG_SPOP_SBC_1	257:261	PDTTS	SPOP	0.7672	More...
Q9UPS6	Histone-lysine N-methyltransferase SETD1B	DEG_SPOP_SBC_1	970:974	PDTTS	SPOP	0.5641	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1878:1882	PDTTS	SPOP	0.9934	More...
Q6ZRK6	Coiled-coil domain-containing protein 73	DEG_SPOP_SBC_1	965:969	PDTTS	SPOP	0.9802	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons