DegronMD - P01042(KNG1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P612T	TCGA-49-AARO	LUAD	TCGA	PDTTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.3056
p.P612T	DO218924	LUAD	ICGC	PDTTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.3056
p.P612Q	TCGA-49-AARO	LUAD	TCGA	PDTTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.3056
p.P612Q	DO218924	LUAD	ICGC	PDTTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.3056
p.D608N	TCGA-5L-AAT1	BRCA	TCGA	PDTTS	DEG_SPOP_SBC_1	607:611	Mutation altering degron motif	0.5821
p.D608N	DO219594	BRCA	ICGC	PDTTS	DEG_SPOP_SBC_1	607:611	Mutation altering degron motif	0.5821
p.P547T	TCGA-86-8073	LUAD	TCGA	PTPIPS	DEG_SCF_FBW7_1	545:550	Mutation altering degron motif	0.7031
p.P547T	DO23624	LUAD	ICGC	PTPIPS	DEG_SCF_FBW7_1	545:550	Mutation altering degron motif	0.7031
p.G597C	TCGA-AX-A06H	UCEC	TCGA	PDTTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.0556
p.G597C	DO43530	UCEC	ICGC	PDTTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.0556
p.T557I	TCGA-BH-A0BP	BRCA	TCGA	PTPIPS	DEG_SCF_FBW7_1	545:550	Mutation rewiring degron network	0.1389
p.T557I	DO4056	BRCA	ICGC	PTPIPS	DEG_SCF_FBW7_1	545:550	Mutation rewiring degron network	0.1389
p.S604L	TCGA-D3-A8GM	SKCM	TCGA	PDTTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.25
p.S604L	TCGA-E9-A226	BRCA	TCGA	PDTTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.25
p.S604L	TCGA-HD-7229	HNSC	TCGA	PDTTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.25
p.S604L	DO3793	BRCA	ICGC	PDTTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.25
p.S604L	DO15479	HNSC	ICGC	PDTTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.25
p.S604L	DO50288	SKCM	ICGC	PDTTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.25
p.S599L	TCGA-DA-A960	SKCM	TCGA	PDTTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.1111
p.S599L	DO219482	SKCM	ICGC	PDTTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.1111
p.G597S	TCGA-DD-AAEK	LIHC	TCGA	PDTTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.0556
p.G597S	DO52273	LIHC	ICGC	PDTTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.0556
p.E543K	TCGA-DU-6392	LGG	TCGA	PTPIPS	DEG_SCF_FBW7_1	545:550	Mutation rewiring degron network	0.2778
p.E543K	DO22237	LGG	ICGC	PTPIPS	DEG_SCF_FBW7_1	545:550	Mutation rewiring degron network	0.2778
p.P615A	TCGA-E9-A226	BRCA	TCGA	PDTTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.2222
p.P615A	DO3793	BRCA	ICGC	PDTTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.2222
p.G616E	TCGA-FS-A1Z3	SKCM	TCGA	PDTTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.1944
p.G616E	DO37635	SKCM	ICGC	PDTTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.1944
p.R617C	TCGA-P6-A5OF	ACC	TCGA	PDTTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.1667
p.D605Y	DO48292	ESCA	ICGC	PDTTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.2778
p.K553E	DO229505	LAML	ICGC	PTPIPS	DEG_SCF_FBW7_1	545:550	Mutation substituting flanking lysine	0.3611
p.K553E	SIDM00425	Ovarian Carcinoma	GDSC	PTPIPS	DEG_SCF_FBW7_1	545:550	Mutation substituting flanking lysine	0.3611
p.K553E	SIDM01020	Plasma Cell Myeloma	GDSC	PTPIPS	DEG_SCF_FBW7_1	545:550	Mutation substituting flanking lysine	0.3611
p.K553E	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	PTPIPS	DEG_SCF_FBW7_1	545:550	Mutation substituting flanking lysine	0.3611
p.K553E	SIDM00238	Ovarian Carcinoma	GDSC	PTPIPS	DEG_SCF_FBW7_1	545:550	Mutation substituting flanking lysine	0.3611
p.K553E	SIDM00564	Ovarian Carcinoma	GDSC	PTPIPS	DEG_SCF_FBW7_1	545:550	Mutation substituting flanking lysine	0.3611
p.K553E	SIDM00567	Other Solid Cancers	GDSC	PTPIPS	DEG_SCF_FBW7_1	545:550	Mutation substituting flanking lysine	0.3611
p.K553E	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	PTPIPS	DEG_SCF_FBW7_1	545:550	Mutation substituting flanking lysine	0.3611
p.K553E	SIDM00274	Gastric Carcinoma	GDSC	PTPIPS	DEG_SCF_FBW7_1	545:550	Mutation substituting flanking lysine	0.3611
p.K553E	SIDM01377	Ovarian Carcinoma	GDSC	PTPIPS	DEG_SCF_FBW7_1	545:550	Mutation substituting flanking lysine	0.3611
p.P547L	DO222638	MELA	ICGC	PTPIPS	DEG_SCF_FBW7_1	545:550	Mutation altering degron motif	0.7582
p.P549L	DO222638	MELA	ICGC	PTPIPS	DEG_SCF_FBW7_1	545:550	Mutation altering degron motif	0.6471
p.P549S	DO222653	MELA	ICGC	PTPIPS	DEG_SCF_FBW7_1	545:550	Mutation altering degron motif	0.5641
p.F560L	DO232761	PBCA	ICGC	PTPIPS	DEG_SCF_FBW7_1	545:550	Mutation rewiring degron network	0.0556
p.S621L	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PDTTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.0556
p.S621L	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PDTTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.0556
p.S621L	ACH-000995	Leukemia	CCLE	PDTTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.0556
p.S621L	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PDTTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.0556
p.K553T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PTPIPS	DEG_SCF_FBW7_1	545:550	Mutation substituting flanking lysine	0.3611
p.K553T	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PTPIPS	DEG_SCF_FBW7_1	545:550	Mutation substituting flanking lysine	0.3611
p.P618S	SIDM00516	Melanoma	GDSC	PDTTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.1389
p.P618S	ACH-002166	Skin Cancer	CCLE	PDTTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.1389
p.P618S	MZ7-mel	skin	COSMIC	PDTTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.1389
p.L598I	SIDM00217	Colorectal Carcinoma	GDSC	PDTTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.0833
p.L598I	ACH-000999	Colon/Colorectal Cancer	CCLE	PDTTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.0833
p.L598I	SNU-1040	large intestine	COSMIC	PDTTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.0833
p.T557A	ACH-002396	Bone Cancer	CCLE	PTPIPS	DEG_SCF_FBW7_1	545:550	Mutation rewiring degron network	0.1389
p.T557A	Sarc9371	bone	COSMIC	PTPIPS	DEG_SCF_FBW7_1	545:550	Mutation rewiring degron network	0.1389

Kaplan plot for KNG1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KNG1

UniProt ID: P01042

Entrez ID: 3827

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KNG1 in