DegronMD

Uniprot ID: P01042

Source protein: Kininogen-1

Source gene: KNG1

Class: DEG_SCF_FBW7_1

Location: 545:550

E3 ligase: FBXW7

DEGRON score: 0.9546

ASA_SCORE: 80.0167

COIL: 0.9192

CONS_SCORE: 0.3658

DSS_SCORE: 0.6792

HELIX: 0.0383

FCONS_SCORE: 0.9601

RIG_SCORE: 0.6589

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P547L	DO222638	MELA	ICGC	PTPIPS	DEG_SCF_FBW7_1	0.7582
p.P547T	TCGA-86-8073	LUAD	TCGA	PTPIPS	DEG_SCF_FBW7_1	0.7031
p.P547T	DO23624	LUAD	ICGC	PTPIPS	DEG_SCF_FBW7_1	0.7031
p.P549L	DO222638	MELA	ICGC	PTPIPS	DEG_SCF_FBW7_1	0.6471
p.P549S	DO222653	MELA	ICGC	PTPIPS	DEG_SCF_FBW7_1	0.5641
p.K553E	DO229505	LAML	ICGC	PTPIPS	DEG_SCF_FBW7_1	0.3611
p.K553E	SIDM00425	Ovarian Carcinoma	GDSC	PTPIPS	DEG_SCF_FBW7_1	0.3611
p.K553E	SIDM01020	Plasma Cell Myeloma	GDSC	PTPIPS	DEG_SCF_FBW7_1	0.3611
p.K553E	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	PTPIPS	DEG_SCF_FBW7_1	0.3611
p.K553E	SIDM00238	Ovarian Carcinoma	GDSC	PTPIPS	DEG_SCF_FBW7_1	0.3611
p.K553E	SIDM00564	Ovarian Carcinoma	GDSC	PTPIPS	DEG_SCF_FBW7_1	0.3611
p.K553E	SIDM00567	Other Solid Cancers	GDSC	PTPIPS	DEG_SCF_FBW7_1	0.3611
p.K553E	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	PTPIPS	DEG_SCF_FBW7_1	0.3611
p.K553E	SIDM00274	Gastric Carcinoma	GDSC	PTPIPS	DEG_SCF_FBW7_1	0.3611
p.K553E	SIDM01377	Ovarian Carcinoma	GDSC	PTPIPS	DEG_SCF_FBW7_1	0.3611
p.K553T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PTPIPS	DEG_SCF_FBW7_1	0.3611
p.K553T	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PTPIPS	DEG_SCF_FBW7_1	0.3611
p.E543K	TCGA-DU-6392	LGG	TCGA	PTPIPS	DEG_SCF_FBW7_1	0.2778
p.E543K	DO22237	LGG	ICGC	PTPIPS	DEG_SCF_FBW7_1	0.2778
p.T557I	TCGA-BH-A0BP	BRCA	TCGA	PTPIPS	DEG_SCF_FBW7_1	0.1389
p.T557I	DO4056	BRCA	ICGC	PTPIPS	DEG_SCF_FBW7_1	0.1389
p.T557A	ACH-002396	Bone Cancer	CCLE	PTPIPS	DEG_SCF_FBW7_1	0.1389
p.T557A	Sarc9371	bone	COSMIC	PTPIPS	DEG_SCF_FBW7_1	0.1389
p.F560L	DO232761	PBCA	ICGC	PTPIPS	DEG_SCF_FBW7_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P01042	Kininogen-1	DEG_SCF_FBW7_1	545:550	PTPIPS	FBXW7	0.9546	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons