DegronMD

Uniprot ID: P01042

Source protein: Kininogen-1

Source gene: KNG1

Class: DEG_SPOP_SBC_1

Location: 607:611

E3 ligase: SPOP

DEGRON score: 0.9956

ASA_SCORE: 73.76

COIL: 0.9382

CONS_SCORE: 0.4357

DSS_SCORE: 0.5823

HELIX: 0.0082

FCONS_SCORE: 0.9295

RIG_SCORE: 0.6608

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P612T	TCGA-49-AARO	LUAD	TCGA	PDTTS	DEG_SPOP_SBC_1	0.3056
p.P612T	DO218924	LUAD	ICGC	PDTTS	DEG_SPOP_SBC_1	0.3056
p.P612Q	TCGA-49-AARO	LUAD	TCGA	PDTTS	DEG_SPOP_SBC_1	0.3056
p.P612Q	DO218924	LUAD	ICGC	PDTTS	DEG_SPOP_SBC_1	0.3056
p.D608N	TCGA-5L-AAT1	BRCA	TCGA	PDTTS	DEG_SPOP_SBC_1	0.5821
p.D608N	DO219594	BRCA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.5821
p.G597C	TCGA-AX-A06H	UCEC	TCGA	PDTTS	DEG_SPOP_SBC_1	0.0556
p.G597C	DO43530	UCEC	ICGC	PDTTS	DEG_SPOP_SBC_1	0.0556
p.S604L	TCGA-D3-A8GM	SKCM	TCGA	PDTTS	DEG_SPOP_SBC_1	0.25
p.S604L	TCGA-E9-A226	BRCA	TCGA	PDTTS	DEG_SPOP_SBC_1	0.25
p.S604L	TCGA-HD-7229	HNSC	TCGA	PDTTS	DEG_SPOP_SBC_1	0.25
p.S604L	DO3793	BRCA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.25
p.S604L	DO15479	HNSC	ICGC	PDTTS	DEG_SPOP_SBC_1	0.25
p.S604L	DO50288	SKCM	ICGC	PDTTS	DEG_SPOP_SBC_1	0.25
p.S599L	TCGA-DA-A960	SKCM	TCGA	PDTTS	DEG_SPOP_SBC_1	0.1111
p.S599L	DO219482	SKCM	ICGC	PDTTS	DEG_SPOP_SBC_1	0.1111
p.G597S	TCGA-DD-AAEK	LIHC	TCGA	PDTTS	DEG_SPOP_SBC_1	0.0556
p.G597S	DO52273	LIHC	ICGC	PDTTS	DEG_SPOP_SBC_1	0.0556
p.P615A	TCGA-E9-A226	BRCA	TCGA	PDTTS	DEG_SPOP_SBC_1	0.2222
p.P615A	DO3793	BRCA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.2222
p.G616E	TCGA-FS-A1Z3	SKCM	TCGA	PDTTS	DEG_SPOP_SBC_1	0.1944
p.G616E	DO37635	SKCM	ICGC	PDTTS	DEG_SPOP_SBC_1	0.1944
p.R617C	TCGA-P6-A5OF	ACC	TCGA	PDTTS	DEG_SPOP_SBC_1	0.1667
p.D605Y	DO48292	ESCA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.2778
p.S621L	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PDTTS	DEG_SPOP_SBC_1	0.0556
p.S621L	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PDTTS	DEG_SPOP_SBC_1	0.0556
p.S621L	ACH-000995	Leukemia	CCLE	PDTTS	DEG_SPOP_SBC_1	0.0556
p.S621L	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PDTTS	DEG_SPOP_SBC_1	0.0556
p.P618S	SIDM00516	Melanoma	GDSC	PDTTS	DEG_SPOP_SBC_1	0.1389
p.P618S	ACH-002166	Skin Cancer	CCLE	PDTTS	DEG_SPOP_SBC_1	0.1389
p.P618S	MZ7-mel	skin	COSMIC	PDTTS	DEG_SPOP_SBC_1	0.1389
p.L598I	SIDM00217	Colorectal Carcinoma	GDSC	PDTTS	DEG_SPOP_SBC_1	0.0833
p.L598I	ACH-000999	Colon/Colorectal Cancer	CCLE	PDTTS	DEG_SPOP_SBC_1	0.0833
p.L598I	SNU-1040	large_intestine	COSMIC	PDTTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P01042	Kininogen-1	DEG_SPOP_SBC_1	607:611	PDTTS	SPOP	0.9956	More...
Q00536	Cyclin-dependent kinase 16	DEG_SPOP_SBC_1	457:461	PDTTS	SPOP	0.5081	More...
Q0VDD7	Break repair meiotic recombinase recruitment factor 1	DEG_SPOP_SBC_1	503:507	PDTTS	SPOP	0.9727	More...
Q13477	Mucosal addressin cell adhesion molecule 1	DEG_SPOP_SBC_1	233:237	PDTTS	SPOP	0.7817	More...
Q13477	Mucosal addressin cell adhesion molecule 1	DEG_SPOP_SBC_1	241:245	PDTTS	SPOP	0.9214	More...
Q13477	Mucosal addressin cell adhesion molecule 1	DEG_SPOP_SBC_1	249:253	PDTTS	SPOP	0.8155	More...
Q13477	Mucosal addressin cell adhesion molecule 1	DEG_SPOP_SBC_1	257:261	PDTTS	SPOP	0.7672	More...
Q9UPS6	Histone-lysine N-methyltransferase SETD1B	DEG_SPOP_SBC_1	970:974	PDTTS	SPOP	0.5641	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1878:1882	PDTTS	SPOP	0.9934	More...
Q6ZRK6	Coiled-coil domain-containing protein 73	DEG_SPOP_SBC_1	965:969	PDTTS	SPOP	0.9802	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PDTTS

Degron related mutations and impact score

Drug responses associated with KNG1 mutations

All proteins holding degron of PDTTS