DegronMD - Q6ZRK6(CCDC73)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D962N	TCGA-38-4625	LUAD	TCGA	PDTTS	DEG_SPOP_SBC_1	965:969	Mutation rewiring degron network	0.25
p.D962N	DO23952	LUAD	ICGC	PDTTS	DEG_SPOP_SBC_1	965:969	Mutation rewiring degron network	0.25
p.D975E	TCGA-63-A5MN	LUSC	TCGA	PDTTS	DEG_SPOP_SBC_1	965:969	Mutation rewiring degron network	0.1667
p.D975E	DO219155	LUSC	ICGC	PDTTS	DEG_SPOP_SBC_1	965:969	Mutation rewiring degron network	0.1667
p.A921V	TCGA-AN-A0XN	BRCA	TCGA	ASSST	DEG_SPOP_SBC_1	921:925	Mutation altering degron motif	0.5825
p.A921V	DO3745	BRCA	ICGC	ASSST	DEG_SPOP_SBC_1	921:925	Mutation altering degron motif	0.5825
p.S924L	TCGA-BA-A6DE	HNSC	TCGA	ASSST	DEG_SPOP_SBC_1	921:925	Mutation altering degron motif	0.7667
p.S924L	TCGA-KL-8337	KICH	TCGA	ASSST	DEG_SPOP_SBC_1	921:925	Mutation altering degron motif	0.7667
p.S924L	DO233156	GACA	ICGC	ASSST	DEG_SPOP_SBC_1	921:925	Mutation altering degron motif	0.7667
p.S924L	DO44438	HNSC	ICGC	ASSST	DEG_SPOP_SBC_1	921:925	Mutation altering degron motif	0.7667
p.S924L	DO220345	KICH	ICGC	ASSST	DEG_SPOP_SBC_1	921:925	Mutation altering degron motif	0.7667
p.S924L	SIDM00404	B-Cell Non-Hodgkin's Lymphoma	GDSC	ASSST	DEG_SPOP_SBC_1	921:925	Mutation altering degron motif	0.7667
p.S924L	ACH-002307	Lymphoma	CCLE	ASSST	DEG_SPOP_SBC_1	921:925	Mutation altering degron motif	0.7667
p.S924L	SU-DHL-16	haematopoietic and lymphoid tissue	COSMIC	ASSST	DEG_SPOP_SBC_1	921:925	Mutation altering degron motif	0.7667
p.E934D	TCGA-BR-6565	STAD	TCGA	ASSST	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.0833
p.E934D	DO38843	STAD	ICGC	ASSST	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.0833
p.L977F	TCGA-G2-A3VY	BLCA	TCGA	PDTTS	DEG_SPOP_SBC_1	965:969	Mutation rewiring degron network	0.1111
p.L977F	DO590	BLCA	ICGC	PDTTS	DEG_SPOP_SBC_1	965:969	Mutation rewiring degron network	0.1111
p.P965L	TCGA-XF-A9T8	BLCA	TCGA	PDTTS	DEG_SPOP_SBC_1	965:969	Mutation altering degron motif	0.7582
p.P965L	DO51927	BLCA	ICGC	PDTTS	DEG_SPOP_SBC_1	965:969	Mutation altering degron motif	0.7582
p.N971K	DO229045	LICA	ICGC	PDTTS	DEG_SPOP_SBC_1	965:969	Mutation rewiring degron network	0.2778
p.N971K	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PDTTS	DEG_SPOP_SBC_1	965:969	Mutation rewiring degron network	0.2778
p.N971K	ACH-000929	Lung Cancer	CCLE	PDTTS	DEG_SPOP_SBC_1	965:969	Mutation rewiring degron network	0.2778
p.N971K	NCI-H2110	lung	COSMIC	PDTTS	DEG_SPOP_SBC_1	965:969	Mutation rewiring degron network	0.2778
p.N971S	DO224638	LUSC	ICGC	PDTTS	DEG_SPOP_SBC_1	965:969	Mutation rewiring degron network	0.2778
p.G964R	SIDM00545	Melanoma	GDSC	PDTTS	DEG_SPOP_SBC_1	965:969	Mutation rewiring degron network	0.3056
p.G964R	ACH-000987	Skin Cancer	CCLE	PDTTS	DEG_SPOP_SBC_1	965:969	Mutation rewiring degron network	0.3056
p.G964R	Mewo	skin	COSMIC	PDTTS	DEG_SPOP_SBC_1	965:969	Mutation rewiring degron network	0.3056
p.V959G	SIDM00007	Other Solid Cancers	GDSC	PDTTS	DEG_SPOP_SBC_1	965:969	Mutation rewiring degron network	0.1667
p.V959G	SIDM00244	Neuroblastoma	GDSC	PDTTS	DEG_SPOP_SBC_1	965:969	Mutation rewiring degron network	0.1667
p.V959G	SIDM00049	Colorectal Carcinoma	GDSC	PDTTS	DEG_SPOP_SBC_1	965:969	Mutation rewiring degron network	0.1667
p.S929F	SIDM00007	Other Solid Cancers	GDSC	ASSST	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.2222
p.S929F	SIDM00244	Neuroblastoma	GDSC	ASSST	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.2222
p.S929F	SIDM00049	Colorectal Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.2222
p.S929A	SIDM00768	Non-Small Cell Lung Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.2222
p.S929A	SIDM00667	Other Sarcomas	GDSC	ASSST	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC73

UniProt ID: Q6ZRK6

Entrez ID: 493860

Protein name: Coiled-coil domain-containing protein 73 (Sarcoma antigen NY-SAR-79)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC73 in