DegronMD

Uniprot ID: Q6ZRK6

Source protein: Coiled-coil domain-containing protein 73

Source gene: CCDC73

Class: DEG_SPOP_SBC_1

Location: 965:969

E3 ligase: SPOP

DEGRON score: 0.9802

ASA_SCORE: 74.84

COIL: 0.74

CONS_SCORE: 0.4948

DSS_SCORE: 0.4574

HELIX: 0.2052

FCONS_SCORE: 1.1432

RIG_SCORE: 0.7493

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D962N	TCGA-38-4625	LUAD	TCGA	PDTTS	DEG_SPOP_SBC_1	0.25
p.D962N	DO23952	LUAD	ICGC	PDTTS	DEG_SPOP_SBC_1	0.25
p.D975E	TCGA-63-A5MN	LUSC	TCGA	PDTTS	DEG_SPOP_SBC_1	0.1667
p.D975E	DO219155	LUSC	ICGC	PDTTS	DEG_SPOP_SBC_1	0.1667
p.L977F	TCGA-G2-A3VY	BLCA	TCGA	PDTTS	DEG_SPOP_SBC_1	0.1111
p.L977F	DO590	BLCA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.1111
p.P965L	TCGA-XF-A9T8	BLCA	TCGA	PDTTS	DEG_SPOP_SBC_1	0.7582
p.P965L	DO51927	BLCA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.7582
p.N971K	DO229045	LICA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.2778
p.N971K	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PDTTS	DEG_SPOP_SBC_1	0.2778
p.N971K	ACH-000929	Lung Cancer	CCLE	PDTTS	DEG_SPOP_SBC_1	0.2778
p.N971K	NCI-H2110	lung	COSMIC	PDTTS	DEG_SPOP_SBC_1	0.2778
p.N971S	DO224638	LUSC	ICGC	PDTTS	DEG_SPOP_SBC_1	0.2778
p.G964R	SIDM00545	Melanoma	GDSC	PDTTS	DEG_SPOP_SBC_1	0.3056
p.G964R	ACH-000987	Skin Cancer	CCLE	PDTTS	DEG_SPOP_SBC_1	0.3056
p.G964R	Mewo	skin	COSMIC	PDTTS	DEG_SPOP_SBC_1	0.3056
p.V959G	SIDM00007	Other Solid Cancers	GDSC	PDTTS	DEG_SPOP_SBC_1	0.1667
p.V959G	SIDM00244	Neuroblastoma	GDSC	PDTTS	DEG_SPOP_SBC_1	0.1667
p.V959G	SIDM00049	Colorectal Carcinoma	GDSC	PDTTS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P01042	Kininogen-1	DEG_SPOP_SBC_1	607:611	PDTTS	SPOP	0.9956	More...
Q00536	Cyclin-dependent kinase 16	DEG_SPOP_SBC_1	457:461	PDTTS	SPOP	0.5081	More...
Q0VDD7	Break repair meiotic recombinase recruitment factor 1	DEG_SPOP_SBC_1	503:507	PDTTS	SPOP	0.9727	More...
Q13477	Mucosal addressin cell adhesion molecule 1	DEG_SPOP_SBC_1	233:237	PDTTS	SPOP	0.7817	More...
Q13477	Mucosal addressin cell adhesion molecule 1	DEG_SPOP_SBC_1	241:245	PDTTS	SPOP	0.9214	More...
Q13477	Mucosal addressin cell adhesion molecule 1	DEG_SPOP_SBC_1	249:253	PDTTS	SPOP	0.8155	More...
Q13477	Mucosal addressin cell adhesion molecule 1	DEG_SPOP_SBC_1	257:261	PDTTS	SPOP	0.7672	More...
Q9UPS6	Histone-lysine N-methyltransferase SETD1B	DEG_SPOP_SBC_1	970:974	PDTTS	SPOP	0.5641	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1878:1882	PDTTS	SPOP	0.9934	More...
Q6ZRK6	Coiled-coil domain-containing protein 73	DEG_SPOP_SBC_1	965:969	PDTTS	SPOP	0.9802	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons