DegronMD

Uniprot ID: Q00536

Source protein: Cyclin-dependent kinase 16

Source gene: CDK16

Class: DEG_SPOP_SBC_1

Location: 457:461

E3 ligase: SPOP

DEGRON score: 0.5081

ASA_SCORE: 72.86

COIL: 0.8954

CONS_SCORE: 0.6769

DSS_SCORE: 0.2521

HELIX: 0.0476

FCONS_SCORE: 1.108

RIG_SCORE: 0.7948

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T459M	TCGA-AD-6889	COAD	TCGA	PDTTS	DEG_SPOP_SBC_1	0.7423
p.T459M	DO8463	COAD	ICGC	PDTTS	DEG_SPOP_SBC_1	0.7423
p.R450H	TCGA-AP-A05D	UCEC	TCGA	PDTTS	DEG_SPOP_SBC_1	0.1389
p.R450H	DO41951	UCEC	ICGC	PDTTS	DEG_SPOP_SBC_1	0.1389
p.R450C	TCGA-AP-A1DV	UCEC	TCGA	PDTTS	DEG_SPOP_SBC_1	0.1389
p.R450C	DO222762	COCA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.1389
p.R450C	DO43186	UCEC	ICGC	PDTTS	DEG_SPOP_SBC_1	0.1389
p.G462C	TCGA-B7-5816	STAD	TCGA	PDTTS	DEG_SPOP_SBC_1	0.3056
p.G462C	DO38599	STAD	ICGC	PDTTS	DEG_SPOP_SBC_1	0.3056
p.P455S	DO224647	BRCA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.7222
p.M447I	DO4743	BRCA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.0556
p.M447I	DO23846	LUAD	ICGC	PDTTS	DEG_SPOP_SBC_1	0.0556
p.E457D	DO5507	BRCA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.6758
p.A470V	DO233747	GACA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.0833
p.S454I	DO228952	LICA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.25
p.E468D	DO229018	LICA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.1389
p.A470S	DO23633	LUAD	ICGC	PDTTS	DEG_SPOP_SBC_1	0.0833
p.I448V	DO51507	PACA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.0833
p.L455P	DO229229	THCA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.7222
p.K448E	DO41343	UCEC	ICGC	PDTTS	DEG_SPOP_SBC_1	0.0833
p.P457A	ACH-000135	Non-Cancerous	CCLE	PDTTS	DEG_SPOP_SBC_1	0.6392

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P01042	Kininogen-1	DEG_SPOP_SBC_1	607:611	PDTTS	SPOP	0.9956	More...
Q00536	Cyclin-dependent kinase 16	DEG_SPOP_SBC_1	457:461	PDTTS	SPOP	0.5081	More...
Q0VDD7	Break repair meiotic recombinase recruitment factor 1	DEG_SPOP_SBC_1	503:507	PDTTS	SPOP	0.9727	More...
Q13477	Mucosal addressin cell adhesion molecule 1	DEG_SPOP_SBC_1	233:237	PDTTS	SPOP	0.7817	More...
Q13477	Mucosal addressin cell adhesion molecule 1	DEG_SPOP_SBC_1	241:245	PDTTS	SPOP	0.9214	More...
Q13477	Mucosal addressin cell adhesion molecule 1	DEG_SPOP_SBC_1	249:253	PDTTS	SPOP	0.8155	More...
Q13477	Mucosal addressin cell adhesion molecule 1	DEG_SPOP_SBC_1	257:261	PDTTS	SPOP	0.7672	More...
Q9UPS6	Histone-lysine N-methyltransferase SETD1B	DEG_SPOP_SBC_1	970:974	PDTTS	SPOP	0.5641	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1878:1882	PDTTS	SPOP	0.9934	More...
Q6ZRK6	Coiled-coil domain-containing protein 73	DEG_SPOP_SBC_1	965:969	PDTTS	SPOP	0.9802	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons