DegronMD

Uniprot ID: Q0VDD7

Source protein: Break repair meiotic recombinase recruitment factor 1

Source gene: BRME1

Class: DEG_SPOP_SBC_1

Location: 503:507

E3 ligase: SPOP

DEGRON score: 0.9727

ASA_SCORE: 79.2

COIL: 0.8176

CONS_SCORE: 0.4946

DSS_SCORE: 0.7633

HELIX: 0.165

FCONS_SCORE: 1.0566

RIG_SCORE: 0.6865

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R513Q	TCGA-39-5028	LUSC	TCGA	PDTTS	DEG_SPOP_SBC_1	0.1667
p.R513Q	DO26442	LUSC	ICGC	PDTTS	DEG_SPOP_SBC_1	0.1667
p.Q512R	TCGA-BR-4362	STAD	TCGA	PDTTS	DEG_SPOP_SBC_1	0.1944
p.Q512R	DO38336	STAD	ICGC	PDTTS	DEG_SPOP_SBC_1	0.1944
p.P503S	TCGA-D3-A8GP	SKCM	TCGA	PDTTS	DEG_SPOP_SBC_1	0.6752
p.P503S	DO51244	SKCM	ICGC	PDTTS	DEG_SPOP_SBC_1	0.6752
p.A510T	DO227549	COCA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.25
p.Q500R	DO229013	COCA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.25
p.Q500R	DO229016	COCA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.25
p.Q500R	DO229480	LAML	ICGC	PDTTS	DEG_SPOP_SBC_1	0.25
p.Q500R	DO228941	LICA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.25
p.Q500R	DO228945	LICA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.25
p.Q500R	DO230527	LUSC	ICGC	PDTTS	DEG_SPOP_SBC_1	0.25
p.Q500R	DO231075	LUSC	ICGC	PDTTS	DEG_SPOP_SBC_1	0.25
p.Q500R	DO231049	LUSC	ICGC	PDTTS	DEG_SPOP_SBC_1	0.25
p.G511R	ACH-000034	Primary	CCLE	PDTTS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P01042	Kininogen-1	DEG_SPOP_SBC_1	607:611	PDTTS	SPOP	0.9956	More...
Q00536	Cyclin-dependent kinase 16	DEG_SPOP_SBC_1	457:461	PDTTS	SPOP	0.5081	More...
Q0VDD7	Break repair meiotic recombinase recruitment factor 1	DEG_SPOP_SBC_1	503:507	PDTTS	SPOP	0.9727	More...
Q13477	Mucosal addressin cell adhesion molecule 1	DEG_SPOP_SBC_1	233:237	PDTTS	SPOP	0.7817	More...
Q13477	Mucosal addressin cell adhesion molecule 1	DEG_SPOP_SBC_1	241:245	PDTTS	SPOP	0.9214	More...
Q13477	Mucosal addressin cell adhesion molecule 1	DEG_SPOP_SBC_1	249:253	PDTTS	SPOP	0.8155	More...
Q13477	Mucosal addressin cell adhesion molecule 1	DEG_SPOP_SBC_1	257:261	PDTTS	SPOP	0.7672	More...
Q9UPS6	Histone-lysine N-methyltransferase SETD1B	DEG_SPOP_SBC_1	970:974	PDTTS	SPOP	0.5641	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1878:1882	PDTTS	SPOP	0.9934	More...
Q6ZRK6	Coiled-coil domain-containing protein 73	DEG_SPOP_SBC_1	965:969	PDTTS	SPOP	0.9802	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons