DegronMD - Q0VDD7(BRME1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A66V	TCGA-2J-AAB1	PAAD	TCGA	AVSSS	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.5825
p.A66V	DO51652	PAAD	ICGC	AVSSS	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.5825
p.A66V	ACH-000770	Leukemia	CCLE	AVSSS	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.5825
p.A66V	ACH-000823	Esophageal Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.5825
p.Q57E	TCGA-33-A4WN	LUSC	TCGA	AVSSS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.0833
p.Q57E	DO219121	LUSC	ICGC	AVSSS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.0833
p.R513Q	TCGA-39-5028	LUSC	TCGA	PDTTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.1667
p.R513Q	DO26442	LUSC	ICGC	PDTTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.1667
p.S70P	TCGA-5P-A9KA	KIRP	TCGA	AVSSS	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.6752
p.S70P	DO223953	KIRP	ICGC	AVSSS	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.6752
p.M430I	TCGA-85-6561	LUSC	TCGA	DSGHAS	DEG_SCF_TRCP1_1	434:439	Mutation rewiring degron network	0.2222
p.M430I	DO26518	LUSC	ICGC	DSGHAS	DEG_SCF_TRCP1_1	434:439	Mutation rewiring degron network	0.2222
p.V67I	TCGA-A6-2686	COAD	TCGA	AVSSS	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.5965
p.V67I	DO7828	COAD	ICGC	AVSSS	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.5965
p.P444Q	TCGA-AX-A0J1	UCEC	TCGA	DSGHAS	DEG_SCF_TRCP1_1	434:439	Mutation rewiring degron network	0.1944
p.P444Q	DO41199	UCEC	ICGC	DSGHAS	DEG_SCF_TRCP1_1	434:439	Mutation rewiring degron network	0.1944
p.Q512R	TCGA-BR-4362	STAD	TCGA	PDTTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.1944
p.Q512R	DO38336	STAD	ICGC	PDTTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.1944
p.P503S	TCGA-D3-A8GP	SKCM	TCGA	PDTTS	DEG_SPOP_SBC_1	503:507	Mutation altering degron motif	0.6752
p.P503S	DO51244	SKCM	ICGC	PDTTS	DEG_SPOP_SBC_1	503:507	Mutation altering degron motif	0.6752
p.D434Y	TCGA-DF-A2KU	UCEC	TCGA	DSGHAS	DEG_SCF_TRCP1_1	434:439	Mutation altering degron motif	0.7325
p.D434Y	DO223286	UCEC	ICGC	DSGHAS	DEG_SCF_TRCP1_1	434:439	Mutation altering degron motif	0.7325
p.Q58K	TCGA-E2-A10C	BRCA	TCGA	AVSSS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1111
p.Q58K	DO1334	BRCA	ICGC	AVSSS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1111
p.G426R	TCGA-WL-A834	CESC	TCGA	DSGHAS	DEG_SCF_TRCP1_1	434:439	Mutation rewiring degron network	0.1111
p.G426R	DO51651	CESC	ICGC	DSGHAS	DEG_SCF_TRCP1_1	434:439	Mutation rewiring degron network	0.1111
p.G426R	DO228123	EOPC	ICGC	DSGHAS	DEG_SCF_TRCP1_1	434:439	Mutation rewiring degron network	0.1111
p.E61K	DO225193	BRCA	ICGC	AVSSS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1944
p.D72N	DO224847	BRCA	ICGC	AVSSS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.2778
p.D72N	DO227473	BRCA	ICGC	AVSSS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.2778
p.A510T	DO227549	COCA	ICGC	PDTTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.25
p.Q500R	DO229013	COCA	ICGC	PDTTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.25
p.Q500R	DO229016	COCA	ICGC	PDTTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.25
p.Q500R	DO229480	LAML	ICGC	PDTTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.25
p.Q500R	DO228941	LICA	ICGC	PDTTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.25
p.Q500R	DO228945	LICA	ICGC	PDTTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.25
p.Q500R	DO230527	LUSC	ICGC	PDTTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.25
p.Q500R	DO231075	LUSC	ICGC	PDTTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.25
p.Q500R	DO231049	LUSC	ICGC	PDTTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.25
p.S70F	DO222705	ESCA	ICGC	AVSSS	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.7982
p.S70F	DO229462	SKCA	ICGC	AVSSS	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.7982
p.S425N	DO233944	GACA	ICGC	DSGHAS	DEG_SCF_TRCP1_1	434:439	Mutation rewiring degron network	0.0833
p.P78S	DO220903	MELA	ICGC	AVSSS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1111
p.G436S	DO228176	PBCA	ICGC	DSGHAS	DEG_SCF_TRCP1_1	434:439	Mutation altering degron motif	0.6993
p.G511R	ACH-000034	Primary	CCLE	PDTTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.2222
p.M429I	ACH-000836	Head and Neck Cancer	CCLE	DSGHAS	DEG_SCF_TRCP1_1	434:439	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BRME1

UniProt ID: Q0VDD7

Entrez ID: 79173

Protein name: Break repair meiotic recombinase recruitment factor 1 (Pre-T/NK cell-associated protein 3B3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BRME1 in