DegronMD

Uniprot ID: Q0VDD7

Source protein: Break repair meiotic recombinase recruitment factor 1

Source gene: BRME1

Class: DEG_SCF_TRCP1_1

Location: 434:439

E3 ligase: BTRC

DEGRON score: 0.9902

ASA_SCORE: 75.75

COIL: 0.9447

CONS_SCORE: 0.5928

DSS_SCORE: 0.7122

HELIX: 0.026

FCONS_SCORE: 1.0363

RIG_SCORE: 0.5175

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M430I	TCGA-85-6561	LUSC	TCGA	DSGHAS	DEG_SCF_TRCP1_1	0.2222
p.M430I	DO26518	LUSC	ICGC	DSGHAS	DEG_SCF_TRCP1_1	0.2222
p.P444Q	TCGA-AX-A0J1	UCEC	TCGA	DSGHAS	DEG_SCF_TRCP1_1	0.1944
p.P444Q	DO41199	UCEC	ICGC	DSGHAS	DEG_SCF_TRCP1_1	0.1944
p.D434Y	TCGA-DF-A2KU	UCEC	TCGA	DSGHAS	DEG_SCF_TRCP1_1	0.7325
p.D434Y	DO223286	UCEC	ICGC	DSGHAS	DEG_SCF_TRCP1_1	0.7325
p.G426R	TCGA-WL-A834	CESC	TCGA	DSGHAS	DEG_SCF_TRCP1_1	0.1111
p.G426R	DO51651	CESC	ICGC	DSGHAS	DEG_SCF_TRCP1_1	0.1111
p.G426R	DO228123	EOPC	ICGC	DSGHAS	DEG_SCF_TRCP1_1	0.1111
p.S425N	DO233944	GACA	ICGC	DSGHAS	DEG_SCF_TRCP1_1	0.0833
p.G436S	DO228176	PBCA	ICGC	DSGHAS	DEG_SCF_TRCP1_1	0.6993
p.M429I	ACH-000836	Head and Neck Cancer	CCLE	DSGHAS	DEG_SCF_TRCP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q0VDD7	Break repair meiotic recombinase recruitment factor 1	DEG_SCF_TRCP1_1	434:439	DSGHAS	BTRC	0.9902	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons