DegronMD - Q00536(CDK16)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T459M	TCGA-AD-6889	COAD	TCGA	PDTTS	DEG_SPOP_SBC_1	457:461	Mutation altering degron motif	0.7423
p.T459M	DO8463	COAD	ICGC	PDTTS	DEG_SPOP_SBC_1	457:461	Mutation altering degron motif	0.7423
p.R450H	TCGA-AP-A05D	UCEC	TCGA	PDTTS	DEG_SPOP_SBC_1	457:461	Mutation rewiring degron network	0.1389
p.R450H	DO41951	UCEC	ICGC	PDTTS	DEG_SPOP_SBC_1	457:461	Mutation rewiring degron network	0.1389
p.R450C	TCGA-AP-A1DV	UCEC	TCGA	PDTTS	DEG_SPOP_SBC_1	457:461	Mutation rewiring degron network	0.1389
p.R450C	DO222762	COCA	ICGC	PDTTS	DEG_SPOP_SBC_1	457:461	Mutation rewiring degron network	0.1389
p.R450C	DO43186	UCEC	ICGC	PDTTS	DEG_SPOP_SBC_1	457:461	Mutation rewiring degron network	0.1389
p.G462C	TCGA-B7-5816	STAD	TCGA	PDTTS	DEG_SPOP_SBC_1	457:461	Mutation rewiring degron network	0.3056
p.G462C	DO38599	STAD	ICGC	PDTTS	DEG_SPOP_SBC_1	457:461	Mutation rewiring degron network	0.3056
p.P455S	DO224647	BRCA	ICGC	PDTTS	DEG_SPOP_SBC_1	457:461	Mutation blocking ubiquitination signal	0.7222
p.M447I	DO4743	BRCA	ICGC	PDTTS	DEG_SPOP_SBC_1	457:461	Mutation rewiring degron network	0.0556
p.M447I	DO23846	LUAD	ICGC	PDTTS	DEG_SPOP_SBC_1	457:461	Mutation rewiring degron network	0.0556
p.E457D	DO5507	BRCA	ICGC	PDTTS	DEG_SPOP_SBC_1	457:461	Mutation altering degron motif	0.6758
p.A470V	DO233747	GACA	ICGC	PDTTS	DEG_SPOP_SBC_1	457:461	Mutation rewiring degron network	0.0833
p.S454I	DO228952	LICA	ICGC	PDTTS	DEG_SPOP_SBC_1	457:461	Mutation rewiring degron network	0.25
p.E468D	DO229018	LICA	ICGC	PDTTS	DEG_SPOP_SBC_1	457:461	Mutation rewiring degron network	0.1389
p.A470S	DO23633	LUAD	ICGC	PDTTS	DEG_SPOP_SBC_1	457:461	Mutation rewiring degron network	0.0833
p.I448V	DO51507	PACA	ICGC	PDTTS	DEG_SPOP_SBC_1	457:461	Mutation rewiring degron network	0.0833
p.L455P	DO229229	THCA	ICGC	PDTTS	DEG_SPOP_SBC_1	457:461	Mutation blocking ubiquitination signal	0.7222
p.K448E	DO41343	UCEC	ICGC	PDTTS	DEG_SPOP_SBC_1	457:461	Mutation rewiring degron network	0.0833
p.P457A	ACH-000135	Non-Cancerous	CCLE	PDTTS	DEG_SPOP_SBC_1	457:461	Mutation altering degron motif	0.6392

Kaplan plot for CDK16 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDK16

UniProt ID: Q00536

Entrez ID: 5127

Protein name: Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDK16 in