DegronMD

Uniprot ID: Q13477

Source protein: Mucosal addressin cell adhesion molecule 1

Source gene: MADCAM1

Class: DEG_SPOP_SBC_1

Location: 257:261

E3 ligase: SPOP

DEGRON score: 0.7672

ASA_SCORE: 89.66

COIL: 0.9594

CONS_SCORE: 0.4069

DSS_SCORE: 0.9569

HELIX: 0.0144

FCONS_SCORE: 0.8899

RIG_SCORE: 0.4678

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P256S	TCGA-AX-A3FS	UCEC	TCGA	PDTTS	DEG_SPOP_SBC_1	0.3056
p.E247K	TCGA-W3-AA1V	SKCM	TCGA	PDTTS	DEG_SPOP_SBC_1	0.0556
p.Q254P	DO229372	BTCA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.25
p.Q254P	DO228912	LICA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.25
p.Q254P	DO228870	LICA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.25
p.Q254P	DO229028	LICA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.25
p.Q254P	DO229008	LICA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.25
p.Q254P	DO23434	LINC	ICGC	PDTTS	DEG_SPOP_SBC_1	0.25
p.Q254P	DO218914	SKCA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.25
p.Q254P	DO229218	THCA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.25
p.D265G	DO10647	COAD	ICGC	PDTTS	DEG_SPOP_SBC_1	0.2222
p.S248P	DO229013	COCA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.0833
p.S248P	DO229003	COCA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.0833
p.S248P	DO223098	ESCA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.0833
p.S248P	DO221062	WT	ICGC	PDTTS	DEG_SPOP_SBC_1	0.0833
p.E263A	DO228058	EOPC	ICGC	PDTTS	DEG_SPOP_SBC_1	0.2778
p.E271D	DO50387	ESAD	ICGC	PDTTS	DEG_SPOP_SBC_1	0.0556
p.P269L	DO49767	KIRP	ICGC	PDTTS	DEG_SPOP_SBC_1	0.1111
p.P269T	DO49767	KIRP	ICGC	PDTTS	DEG_SPOP_SBC_1	0.1111
p.P269T	BALL-1	haematopoietic_and_lymphoid_tissue	COSMIC	PDTTS	DEG_SPOP_SBC_1	0.1111
p.K267T	DO51042	LAML	ICGC	PDTTS	DEG_SPOP_SBC_1	0.2778
p.K267T	DO228974	LICA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.2778
p.K267T	DO229510	SKCA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.2778
p.K267T	DO229275	THCA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.2778
p.L254I	DO232861	NACA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.25
p.R257H	DO32916	PACA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.8244
p.R257H	DO38404	STAD	ICGC	PDTTS	DEG_SPOP_SBC_1	0.8244
p.E263K	DO50288	SKCM	ICGC	PDTTS	DEG_SPOP_SBC_1	0.2778
p.D266E	DO229275	THCA	ICGC	PDTTS	DEG_SPOP_SBC_1	0.1944
p.R259W	DO50076	UCEC	ICGC	PDTTS	DEG_SPOP_SBC_1	0.8634
p.R257C	DO41572	UCEC	ICGC	PDTTS	DEG_SPOP_SBC_1	0.8301
p.P264S	SIDM01020	Plasma Cell Myeloma	GDSC	PDTTS	DEG_SPOP_SBC_1	0.25
p.E247D	SIDM00694	Other Solid Cancers	GDSC	PDTTS	DEG_SPOP_SBC_1	0.0556
p.E247D	SIDM00760	Small Cell Lung Carcinoma	GDSC	PDTTS	DEG_SPOP_SBC_1	0.0556
p.S269F	SIDM00542	Glioblastoma	GDSC	PDTTS	DEG_SPOP_SBC_1	0.1111
p.E255K	ACH-001569	Skin Cancer	CCLE	PDTTS	DEG_SPOP_SBC_1	0.2778
p.A248V	UDSCC2	upper_aerodigestive_tract	COSMIC	PDTTS	DEG_SPOP_SBC_1	0.0833
p.P254R	SNU-1040	large_intestine	COSMIC	PDTTS	DEG_SPOP_SBC_1	0.25
p.S271F	NCI-H2342	lung	COSMIC	PDTTS	DEG_SPOP_SBC_1	0.0556
p.P248L	HT-115	large_intestine	COSMIC	PDTTS	DEG_SPOP_SBC_1	0.0833
p.P262R	SNU-1040	large_intestine	COSMIC	PDTTS	DEG_SPOP_SBC_1	0.3056
p.P256L	HT-115	large_intestine	COSMIC	PDTTS	DEG_SPOP_SBC_1	0.3056
p.P256R	SNU-1040	large_intestine	COSMIC	PDTTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P01042	Kininogen-1	DEG_SPOP_SBC_1	607:611	PDTTS	SPOP	0.9956	More...
Q00536	Cyclin-dependent kinase 16	DEG_SPOP_SBC_1	457:461	PDTTS	SPOP	0.5081	More...
Q0VDD7	Break repair meiotic recombinase recruitment factor 1	DEG_SPOP_SBC_1	503:507	PDTTS	SPOP	0.9727	More...
Q13477	Mucosal addressin cell adhesion molecule 1	DEG_SPOP_SBC_1	233:237	PDTTS	SPOP	0.7817	More...
Q13477	Mucosal addressin cell adhesion molecule 1	DEG_SPOP_SBC_1	241:245	PDTTS	SPOP	0.9214	More...
Q13477	Mucosal addressin cell adhesion molecule 1	DEG_SPOP_SBC_1	249:253	PDTTS	SPOP	0.8155	More...
Q13477	Mucosal addressin cell adhesion molecule 1	DEG_SPOP_SBC_1	257:261	PDTTS	SPOP	0.7672	More...
Q9UPS6	Histone-lysine N-methyltransferase SETD1B	DEG_SPOP_SBC_1	970:974	PDTTS	SPOP	0.5641	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1878:1882	PDTTS	SPOP	0.9934	More...
Q6ZRK6	Coiled-coil domain-containing protein 73	DEG_SPOP_SBC_1	965:969	PDTTS	SPOP	0.9802	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PDTTS

Degron related mutations and impact score

Drug responses associated with MADCAM1 mutations

All proteins holding degron of PDTTS