DegronMD

Uniprot ID: Q9UPS6

Source protein: Histone-lysine N-methyltransferase SETD1B

Source gene: SETD1B

Class: DEG_SCF_FBW7_2

Location: 480:486

E3 ligase: FBXW7

DEGRON score: 0.9847

ASA_SCORE: 82.8429

COIL: 0.92

CONS_SCORE: 0.3045

DSS_SCORE: 0.7951

HELIX: 0.0461

FCONS_SCORE: 1.1697

RIG_SCORE: 0.5666

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T484R	ACH-000395	Lung Cancer	CCLE	PGTPTLE	DEG_SCF_FBW7_2	0.6765
p.T482M	ACH-000790	Lung Cancer	CCLE	PGTPTLE	DEG_SCF_FBW7_2	0.7423
p.T482M	ACH-001333	Cervical Cancer	CCLE	PGTPTLE	DEG_SCF_FBW7_2	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPS6	Histone-lysine N-methyltransferase SETD1B	DEG_SCF_FBW7_2	480:486	PGTPTLE	FBXW7	0.9847	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons