DegronMD - Q9NWH9(SLTM)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E775Q	TCGA-33-AASI	LUSC	TCGA	VQSSS	DEG_SPOP_SBC_1	785:789	Mutation rewiring degron network	0.0556
p.V797I	TCGA-AA-A01P	COAD	TCGA	VQSSS	DEG_SPOP_SBC_1	785:789	Mutation rewiring degron network	0.1111
p.R795H	TCGA-AX-A0J1	UCEC	TCGA	VQSSS	DEG_SPOP_SBC_1	785:789	Mutation rewiring degron network	0.1667
p.E775D	TCGA-AX-A2HC	UCEC	TCGA	VQSSS	DEG_SPOP_SBC_1	785:789	Mutation rewiring degron network	0.0556
p.V797D	TCGA-C4-A0F6	BLCA	TCGA	VQSSS	DEG_SPOP_SBC_1	785:789	Mutation rewiring degron network	0.1111
p.R793W	TCGA-E9-A5UO	BRCA	TCGA	VQSSS	DEG_SPOP_SBC_1	785:789	Mutation rewiring degron network	0.2222
p.E775K	TCGA-EE-A2M5	SKCM	TCGA	VQSSS	DEG_SPOP_SBC_1	785:789	Mutation rewiring degron network	0.0556
p.P780S	TCGA-EE-A2MS	SKCM	TCGA	VQSSS	DEG_SPOP_SBC_1	785:789	Mutation rewiring degron network	0.1944
p.P780S	TCGA-W3-AA1V	SKCM	TCGA	VQSSS	DEG_SPOP_SBC_1	785:789	Mutation rewiring degron network	0.1944
p.P780S	SIDM00379	Glioma	GDSC	VQSSS	DEG_SPOP_SBC_1	785:789	Mutation rewiring degron network	0.1944
p.P780S	ACH-002304	Brain Cancer	CCLE	VQSSS	DEG_SPOP_SBC_1	785:789	Mutation rewiring degron network	0.1944
p.P780S	SK-MG-1	central nervous system	COSMIC	VQSSS	DEG_SPOP_SBC_1	785:789	Mutation rewiring degron network	0.1944
p.V797A	TCGA-FI-A2D5	UCEC	TCGA	VQSSS	DEG_SPOP_SBC_1	785:789	Mutation rewiring degron network	0.1111
p.D794Y	TCGA-NC-A5HH	LUSC	TCGA	VQSSS	DEG_SPOP_SBC_1	785:789	Mutation rewiring degron network	0.1944
p.S365C	TCGA-Q1-A73O	CESC	TCGA	AKSSS	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.0556
p.R362W	DO44105	BRCA	ICGC	AKSSS	DEG_SPOP_SBC_1	351:355	Mutation substituting flanking lysine	0.25
p.R362Q	DO234265	ESAD	ICGC	AKSSS	DEG_SPOP_SBC_1	351:355	Mutation substituting flanking lysine	0.25
p.K352Q	DO233093	GACA	ICGC	AKSSS	DEG_SPOP_SBC_1	351:355	Mutation altering degron motif	0.5833
p.R361S	DO228933	LICA	ICGC	AKSSS	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.1667
p.H342Q	DO229029	LICA	ICGC	AKSSS	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.0833
p.D360E	DO229027	LICA	ICGC	AKSSS	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.1944
p.T363K	DO229009	LICA	ICGC	AKSSS	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.1111
p.E344Q	DO219129	LUSC	ICGC	AKSSS	DEG_SPOP_SBC_1	351:355	Mutation blocking phosphorylation signal	0.5833
p.D363Y	DO219187	LUSC	ICGC	AKSSS	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.1111
p.E344K	DO222423	MELA	ICGC	AKSSS	DEG_SPOP_SBC_1	351:355	Mutation blocking phosphorylation signal	0.5833
p.E344K	DO37425	SKCM	ICGC	AKSSS	DEG_SPOP_SBC_1	351:355	Mutation blocking phosphorylation signal	0.5833
p.P349S	DO37567	SKCM	ICGC	AKSSS	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.2778
p.P349S	DO51276	SKCM	ICGC	AKSSS	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.2778
p.E344D	DO41572	UCEC	ICGC	AKSSS	DEG_SPOP_SBC_1	351:355	Mutation blocking phosphorylation signal	0.5833
p.R364H	DO41199	UCEC	ICGC	AKSSS	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.0833
p.R795C	SIDM01134	Small Cell Lung Carcinoma	GDSC	VQSSS	DEG_SPOP_SBC_1	785:789	Mutation rewiring degron network	0.1667
p.R795C	ACH-000292	Lung Cancer	CCLE	VQSSS	DEG_SPOP_SBC_1	785:789	Mutation rewiring degron network	0.1667
p.S365A	SIDM00849	Kidney Carcinoma	GDSC	AKSSS	DEG_SPOP_SBC_1	351:355	Mutation rewiring degron network	0.0556

Kaplan plot for SLTM in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLTM

UniProt ID: Q9NWH9

Entrez ID: 79811

Protein name: SAFB-like transcription modulator (Modulator of estrogen-induced transcription)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLTM in