DegronMD - Q8WUF8(FAM172A)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D218N	TCGA-29-1688	OV	TCGA	VQSSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.3056
p.D218N	DO28026	OV	ICGC	VQSSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.3056
p.Q214L	TCGA-BF-AAOX	SKCM	TCGA	VQSSS	DEG_SPOP_SBC_1	213:217	Mutation altering degron motif	0.6654
p.Q214L	DO223907	SKCM	ICGC	VQSSS	DEG_SPOP_SBC_1	213:217	Mutation altering degron motif	0.6654
p.D218H	TCGA-C5-A7UH	CESC	TCGA	VQSSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.3056
p.D218H	TCGA-EY-A1GS	UCEC	TCGA	VQSSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.3056
p.D218H	DO49891	CESC	ICGC	VQSSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.3056
p.D218H	DO43162	UCEC	ICGC	VQSSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.3056
p.R227Q	TCGA-CM-6677	COAD	TCGA	VQSSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.0556
p.R227Q	DO8570	COAD	ICGC	VQSSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.0556
p.R227W	DO222507	COCA	ICGC	VQSSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.0556
p.E225K	SIDM00190	Melanoma	GDSC	VQSSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.1111
p.E225K	CP66-MEL	skin	COSMIC	VQSSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.1111
p.V213I	SIDM00238	Ovarian Carcinoma	GDSC	VQSSS	DEG_SPOP_SBC_1	213:217	Mutation altering degron motif	0.7076
p.V213I	OVK-18	ovary	COSMIC	VQSSS	DEG_SPOP_SBC_1	213:217	Mutation altering degron motif	0.7076

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons