DegronMD - Q9H2G4(TSPYL2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P119R	TCGA-85-8350	LUSC	TCGA	LPTPEAS	DEG_SCF_FBW7_1	118:124	Mutation altering degron motif	0.6401
p.P119R	DO45492	LUSC	ICGC	LPTPEAS	DEG_SCF_FBW7_1	118:124	Mutation altering degron motif	0.6401
p.E129K	TCGA-GF-A6C8	SKCM	TCGA	LPTPEAS	DEG_SCF_FBW7_1	118:124	Mutation rewiring degron network	0.1944
p.E129K	TCGA-GF-A6C8	SKCM	TCGA	VQSSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.1667
p.E129K	DO48765	SKCM	ICGC	LPTPEAS	DEG_SCF_FBW7_1	118:124	Mutation rewiring degron network	0.1944
p.E129K	DO48765	SKCM	ICGC	VQSSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.1667
p.G67C	DO5745	BRCA	ICGC	PPPY	ITCH	73:76	Mutation rewiring degron network	0.1667
p.A108V	DO228935	COCA	ICGC	LPTPEAS	DEG_SCF_FBW7_1	118:124	Mutation rewiring degron network	0.0556
p.P73L	DO233089	GACA	ICGC	PPPY	ITCH	73:76	Mutation altering degron motif	0.7582
p.P73L	DO233634	GACA	ICGC	PPPY	ITCH	73:76	Mutation altering degron motif	0.7582
p.A145S	DO229029	LICA	ICGC	VQSSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.1667
p.A145T	DO45299	LIRI	ICGC	VQSSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.1667
p.Y76C	DO229213	THCA	ICGC	PPPY	ITCH	73:76	Mutation altering degron motif	0.7087
p.A69V	DO41199	UCEC	ICGC	PPPY	ITCH	73:76	Mutation rewiring degron network	0.2222
p.T112M	SIDM01004	Chronic Myelogenous Leukemia	GDSC	LPTPEAS	DEG_SCF_FBW7_1	118:124	Mutation rewiring degron network	0.1667
p.T112M	ACH-000983	Leukemia	CCLE	LPTPEAS	DEG_SCF_FBW7_1	118:124	Mutation rewiring degron network	0.1667
p.G125V	SIDM00545	Melanoma	GDSC	LPTPEAS	DEG_SCF_FBW7_1	118:124	Mutation rewiring degron network	0.3056
p.G125V	SIDM00545	Melanoma	GDSC	VQSSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.0556
p.G125V	SIDM00915	Small Cell Lung Carcinoma	GDSC	LPTPEAS	DEG_SCF_FBW7_1	118:124	Mutation rewiring degron network	0.3056
p.G125V	SIDM00915	Small Cell Lung Carcinoma	GDSC	VQSSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.0556
p.G125V	NCI-H378	lung	COSMIC	LPTPEAS	DEG_SCF_FBW7_1	118:124	Mutation rewiring degron network	0.3056
p.G125V	NCI-H378	lung	COSMIC	VQSSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.0556
p.G125V	Mewo	skin	COSMIC	LPTPEAS	DEG_SCF_FBW7_1	118:124	Mutation rewiring degron network	0.3056
p.G125V	Mewo	skin	COSMIC	VQSSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.0556
p.T148I	SIDM01187	Breast Carcinoma	GDSC	VQSSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.0833
p.T148I	UACC-812	breast	COSMIC	VQSSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.0833
p.E113K	ACH-000350	Colon/Colorectal Cancer	CCLE	LPTPEAS	DEG_SCF_FBW7_1	118:124	Mutation rewiring degron network	0.1944
p.I78T	ACH-000961	Endometrial/Uterine Cancer	CCLE	PPPY	ITCH	73:76	Mutation rewiring degron network	0.2778

Kaplan plot for TSPYL2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TSPYL2

UniProt ID: Q9H2G4

Entrez ID: 64061

Protein name: Testis-specific Y-encoded-like protein 2 (TSPY-like protein 2) (Cell division autoantigen 1) (Cutaneous T-cell lymphoma-associated antigen se20-4) (CTCL-associated antigen se20-4) (Differentially-expressed nucleolar TGF-beta1 target protein) (Nuclear protein of 79 kDa) (NP79)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for TSPYL2 in