DegronMD

Uniprot ID: Q9H2G4

Source protein: Testis-specific Y-encoded-like protein 2

Source gene: TSPYL2

Class: DEG_SCF_FBW7_1

Location: 118:124

E3 ligase: FBXW7

DEGRON score: 0.9886

ASA_SCORE: 77.7571

COIL: 0.885

CONS_SCORE: 0.2261

DSS_SCORE: 0.6468

HELIX: 0.0587

FCONS_SCORE: 0.8802

RIG_SCORE: 0.6683

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P119R	TCGA-85-8350	LUSC	TCGA	LPTPEAS	DEG_SCF_FBW7_1	0.6401
p.P119R	DO45492	LUSC	ICGC	LPTPEAS	DEG_SCF_FBW7_1	0.6401
p.E129K	TCGA-GF-A6C8	SKCM	TCGA	LPTPEAS	DEG_SCF_FBW7_1	0.1944
p.E129K	DO48765	SKCM	ICGC	LPTPEAS	DEG_SCF_FBW7_1	0.1944
p.A108V	DO228935	COCA	ICGC	LPTPEAS	DEG_SCF_FBW7_1	0.0556
p.T112M	SIDM01004	Chronic Myelogenous Leukemia	GDSC	LPTPEAS	DEG_SCF_FBW7_1	0.1667
p.T112M	ACH-000983	Leukemia	CCLE	LPTPEAS	DEG_SCF_FBW7_1	0.1667
p.G125V	SIDM00545	Melanoma	GDSC	LPTPEAS	DEG_SCF_FBW7_1	0.3056
p.G125V	SIDM00915	Small Cell Lung Carcinoma	GDSC	LPTPEAS	DEG_SCF_FBW7_1	0.3056
p.G125V	NCI-H378	lung	COSMIC	LPTPEAS	DEG_SCF_FBW7_1	0.3056
p.G125V	Mewo	skin	COSMIC	LPTPEAS	DEG_SCF_FBW7_1	0.3056
p.E113K	ACH-000350	Colon/Colorectal Cancer	CCLE	LPTPEAS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H2G4	Testis-specific Y-encoded-like protein 2	DEG_SCF_FBW7_1	118:124	LPTPEAS	FBXW7	0.9886	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons