DegronMD

Uniprot ID: O14917

Source protein: Protocadherin-17

Source gene: PCDH17

Class: DEG_Kelch_Keap1_1

Location: 639:644

E3 ligase: KEAP1

DEGRON score: 0.738

ASA_SCORE: 42.8667

COIL: 0.8023

CONS_SCORE: 0.6389

DSS_SCORE: 0.3316

HELIX: 0.02

FCONS_SCORE: 1.2042

RIG_SCORE: 0.7188

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D654Y	TCGA-17-Z059	LUAD	TCGA	DPSSGE	DEG_Kelch_Keap1_1	0.0556
p.E653A	TCGA-5M-AAT6	COAD	TCGA	DPSSGE	DEG_Kelch_Keap1_1	0.0833
p.E653A	DO223703	COAD	ICGC	DPSSGE	DEG_Kelch_Keap1_1	0.0833
p.I645V	TCGA-61-2096	OV	TCGA	DPSSGE	DEG_Kelch_Keap1_1	0.3056
p.I645V	DO29708	OV	ICGC	DPSSGE	DEG_Kelch_Keap1_1	0.3056
p.R646S	TCGA-AA-3663	COAD	TCGA	DPSSGE	DEG_Kelch_Keap1_1	0.2778
p.R646S	DO9346	COAD	ICGC	DPSSGE	DEG_Kelch_Keap1_1	0.2778
p.D639N	TCGA-AP-A059	UCEC	TCGA	DPSSGE	DEG_Kelch_Keap1_1	0.5821
p.D639N	DO41361	UCEC	ICGC	DPSSGE	DEG_Kelch_Keap1_1	0.5821
p.H634R	TCGA-BG-A222	UCEC	TCGA	DPSSGE	DEG_Kelch_Keap1_1	0.1944
p.H634R	DO42977	UCEC	ICGC	DPSSGE	DEG_Kelch_Keap1_1	0.1944
p.R646H	TCGA-BR-7851	STAD	TCGA	DPSSGE	DEG_Kelch_Keap1_1	0.2778
p.R646H	DO38711	STAD	ICGC	DPSSGE	DEG_Kelch_Keap1_1	0.2778
p.E644D	TCGA-CV-6961	HNSC	TCGA	DPSSGE	DEG_Kelch_Keap1_1	0.6758
p.E644D	DO14566	HNSC	ICGC	DPSSGE	DEG_Kelch_Keap1_1	0.6758
p.E637Q	TCGA-D6-8569	HNSC	TCGA	DPSSGE	DEG_Kelch_Keap1_1	0.2778
p.E637Q	DO14454	HNSC	ICGC	DPSSGE	DEG_Kelch_Keap1_1	0.2778
p.P650S	TCGA-EE-A2GB	SKCM	TCGA	DPSSGE	DEG_Kelch_Keap1_1	0.1667
p.P650S	DO222683	MELA	ICGC	DPSSGE	DEG_Kelch_Keap1_1	0.1667
p.P650S	DO37417	SKCM	ICGC	DPSSGE	DEG_Kelch_Keap1_1	0.1667
p.D629Y	TCGA-V5-A7RC	ESCA	TCGA	DPSSGE	DEG_Kelch_Keap1_1	0.0556
p.N631T	DO50338	ESAD	ICGC	DPSSGE	DEG_Kelch_Keap1_1	0.1111
p.T647M	DO233767	GACA	ICGC	DPSSGE	DEG_Kelch_Keap1_1	0.6944
p.T647M	SIDM02035	Colorectal Carcinoma	GDSC	DPSSGE	DEG_Kelch_Keap1_1	0.6944
p.D632G	DO233701	GACA	ICGC	DPSSGE	DEG_Kelch_Keap1_1	0.1389
p.I645N	DO224719	PACA	ICGC	DPSSGE	DEG_Kelch_Keap1_1	0.3056
p.P640S	DO219878	SKCA	ICGC	DPSSGE	DEG_Kelch_Keap1_1	0.5641
p.S642I	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	DPSSGE	DEG_Kelch_Keap1_1	0.8453
p.S642I	ACH-000914	Lymphoma	CCLE	DPSSGE	DEG_Kelch_Keap1_1	0.8453
p.S642I	HT	haematopoietic_and_lymphoid_tissue	COSMIC	DPSSGE	DEG_Kelch_Keap1_1	0.8453
p.G630D	SIDM00118	Colorectal Carcinoma	GDSC	DPSSGE	DEG_Kelch_Keap1_1	0.0833
p.G630D	ACH-001081	Colon/Colorectal Cancer	CCLE	DPSSGE	DEG_Kelch_Keap1_1	0.0833
p.G630D	HCC2998	large_intestine	COSMIC	DPSSGE	DEG_Kelch_Keap1_1	0.0833
p.E637D	ACH-001656	Leukemia	CCLE	DPSSGE	DEG_Kelch_Keap1_1	0.2778
p.L648P	ACH-001786	Colon/Colorectal Cancer	CCLE	DPSSGE	DEG_Kelch_Keap1_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DPSSGE

Degron related mutations and impact score

Drug responses associated with PCDH17 mutations

All proteins holding degron of DPSSGE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14917	Protocadherin-17	DEG_Kelch_Keap1_1	639:644	DPSSGE	KEAP1	0.738	More...