DegronMD

Uniprot ID: Q8IUM7

Source protein: Neuronal PAS domain-containing protein 4

Source gene: NPAS4

Class: DEG_SCF_FBW7_1

Location: 531:536

E3 ligase: FBXW7

DEGRON score: 0.9958

ASA_SCORE: 55.8833

COIL: 0.904

CONS_SCORE: 0.461

DSS_SCORE: 0.7104

HELIX: 0.0433

FCONS_SCORE: 1.3236

RIG_SCORE: 0.6163

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P545H	TCGA-99-8032	LUAD	TCGA	LTPPST	DEG_SCF_FBW7_1	0.0833
p.P545H	DO23765	LUAD	ICGC	LTPPST	DEG_SCF_FBW7_1	0.0833
p.S544N	TCGA-AM-5821	COAD	TCGA	LTPPST	DEG_SCF_FBW7_1	0.1111
p.S544N	DO8240	COAD	ICGC	LTPPST	DEG_SCF_FBW7_1	0.1111
p.S544N	SIDM00499	Prostate Carcinoma	GDSC	LTPPST	DEG_SCF_FBW7_1	0.1111
p.S544N	ACH-000956	Prostate Cancer	CCLE	LTPPST	DEG_SCF_FBW7_1	0.1111
p.S544N	22RV1	prostate	COSMIC	LTPPST	DEG_SCF_FBW7_1	0.1111
p.H528Y	TCGA-BF-A1PX	SKCM	TCGA	LTPPST	DEG_SCF_FBW7_1	0.25
p.H528Y	DO51236	SKCM	ICGC	LTPPST	DEG_SCF_FBW7_1	0.25
p.P533S	TCGA-DA-A1I0	SKCM	TCGA	LTPPST	DEG_SCF_FBW7_1	0.6752
p.P533S	TCGA-FS-A1ZC	SKCM	TCGA	LTPPST	DEG_SCF_FBW7_1	0.6752
p.P533S	DO37719	SKCM	ICGC	LTPPST	DEG_SCF_FBW7_1	0.6752
p.P533S	DO37487	SKCM	ICGC	LTPPST	DEG_SCF_FBW7_1	0.6752
p.Q539E	DO229013	COCA	ICGC	LTPPST	DEG_SCF_FBW7_1	0.25
p.D543E	DO233259	GACA	ICGC	LTPPST	DEG_SCF_FBW7_1	0.1389
p.A537T	SIDM00126	Melanoma	GDSC	LTPPST	DEG_SCF_FBW7_1	0.3056
p.A537T	ACH-002147	Skin Cancer	CCLE	LTPPST	DEG_SCF_FBW7_1	0.3056
p.A537T	K2	skin	COSMIC	LTPPST	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86X29	Lipolysis-stimulated lipoprotein receptor	DEG_SCF_FBW7_1	500:505	LTPPST	FBXW7	0.9895	More...
Q8IUM7	Neuronal PAS domain-containing protein 4	DEG_SCF_FBW7_1	531:536	LTPPST	FBXW7	0.9958	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons