DegronMD

Uniprot ID: Q86X29

Source protein: Lipolysis-stimulated lipoprotein receptor

Source gene: LSR

Class: DEG_SCF_FBW7_1

Location: 500:505

E3 ligase: FBXW7

DEGRON score: 0.9895

ASA_SCORE: 80.95

COIL: 0.9257

CONS_SCORE: 0.3366

DSS_SCORE: 0.7252

HELIX: 0.0613

FCONS_SCORE: 0.5954

RIG_SCORE: 0.615

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S510G	TCGA-EB-A85I	SKCM	TCGA	LTPPST	DEG_SCF_FBW7_1	0.6389
p.R510S	DO9708	COAD	ICGC	LTPPST	DEG_SCF_FBW7_1	0.6389
p.P507L	DO48290	ESCA	ICGC	LTPPST	DEG_SCF_FBW7_1	0.2778
p.G498A	DO228807	LICA	ICGC	LTPPST	DEG_SCF_FBW7_1	0.2778
p.R508W	DO25847	LUAD	ICGC	LTPPST	DEG_SCF_FBW7_1	0.6944
p.Y504N	DO228568	MALY	ICGC	LTPPST	DEG_SCF_FBW7_1	0.7059
p.S491G	DO50296	SKCM	ICGC	LTPPST	DEG_SCF_FBW7_1	0.0833
p.T505S	SIDM01233	Colorectal Carcinoma	GDSC	LTPPST	DEG_SCF_FBW7_1	0.7116
p.T505S	ACH-000003		CCLE	LTPPST	DEG_SCF_FBW7_1	0.7116
p.T505S	ACH-000009	Colon/Colorectal Cancer	CCLE	LTPPST	DEG_SCF_FBW7_1	0.7116
p.P503L	SIDM00153	T-Lymphoblastic Leukemia	GDSC	LTPPST	DEG_SCF_FBW7_1	0.6471
p.P503L	ACH-000964	Leukemia	CCLE	LTPPST	DEG_SCF_FBW7_1	0.6471
p.T501P	ACH-000703	Lung Cancer	CCLE	LTPPST	DEG_SCF_FBW7_1	0.8142
p.E507K	ACH-001608	Brain Cancer	CCLE	LTPPST	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86X29	Lipolysis-stimulated lipoprotein receptor	DEG_SCF_FBW7_1	500:505	LTPPST	FBXW7	0.9895	More...
Q8IUM7	Neuronal PAS domain-containing protein 4	DEG_SCF_FBW7_1	531:536	LTPPST	FBXW7	0.9958	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons