DegronMD - Q86X29(LSR)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T626S	TCGA-AX-A05S	UCEC	TCGA	PPPY	ITCH	620:623	Mutation rewiring degron network	0.25
p.S510G	TCGA-EB-A85I	SKCM	TCGA	LTPPST	DEG_SCF_FBW7_1	500:505	Mutation blocking phosphorylation signal	0.6389
p.P620S	TCGA-FI-A2D6	UCEC	TCGA	PPPY	ITCH	620:623	Mutation altering degron motif	0.6752
p.L617V	DO9362	COAD	ICGC	PPPY	ITCH	620:623	Mutation rewiring degron network	0.25
p.R510S	DO9708	COAD	ICGC	LTPPST	DEG_SCF_FBW7_1	500:505	Mutation blocking phosphorylation signal	0.6389
p.P507L	DO48290	ESCA	ICGC	LTPPST	DEG_SCF_FBW7_1	500:505	Mutation rewiring degron network	0.2778
p.G498A	DO228807	LICA	ICGC	LTPPST	DEG_SCF_FBW7_1	500:505	Mutation rewiring degron network	0.2778
p.V630F	DO229015	LICA	ICGC	PPPY	ITCH	620:623	Mutation rewiring degron network	0.1389
p.R508W	DO25847	LUAD	ICGC	LTPPST	DEG_SCF_FBW7_1	500:505	Mutation blocking phosphorylation signal	0.6944
p.Y504N	DO228568	MALY	ICGC	LTPPST	DEG_SCF_FBW7_1	500:505	Mutation altering degron motif	0.7059
p.K619Q	DO36556	READ	ICGC	PPPY	ITCH	620:623	Mutation rewiring degron network	0.3056
p.S491G	DO50296	SKCM	ICGC	LTPPST	DEG_SCF_FBW7_1	500:505	Mutation rewiring degron network	0.0833
p.T626I	SIDM00403	T-Lymphoblastic Leukemia	GDSC	PPPY	ITCH	620:623	Mutation rewiring degron network	0.25
p.T626I	ACH-000636	Leukemia	CCLE	PPPY	ITCH	620:623	Mutation rewiring degron network	0.25
p.T626I	RPMI-8402	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	620:623	Mutation rewiring degron network	0.25
p.T505S	SIDM01233	Colorectal Carcinoma	GDSC	LTPPST	DEG_SCF_FBW7_1	500:505	Mutation altering degron motif	0.7116
p.T505S	ACH-000003		CCLE	LTPPST	DEG_SCF_FBW7_1	500:505	Mutation altering degron motif	0.7116
p.T505S	ACH-000009	Colon/Colorectal Cancer	CCLE	LTPPST	DEG_SCF_FBW7_1	500:505	Mutation altering degron motif	0.7116
p.E633K	SIDM00810	Non-Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	620:623	Mutation rewiring degron network	0.0556
p.E633K	SIDM01148	Plasma Cell Myeloma	GDSC	PPPY	ITCH	620:623	Mutation rewiring degron network	0.0556
p.E633K	SIDM01056	Breast Carcinoma	GDSC	PPPY	ITCH	620:623	Mutation rewiring degron network	0.0556
p.E633K	SIDM00124	Kidney Carcinoma	GDSC	PPPY	ITCH	620:623	Mutation rewiring degron network	0.0556
p.E633K	SIDM01775	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPPY	ITCH	620:623	Mutation rewiring degron network	0.0556
p.P503L	SIDM00153	T-Lymphoblastic Leukemia	GDSC	LTPPST	DEG_SCF_FBW7_1	500:505	Mutation altering degron motif	0.6471
p.P503L	ACH-000964	Leukemia	CCLE	LTPPST	DEG_SCF_FBW7_1	500:505	Mutation altering degron motif	0.6471
p.E612D	SIDM01450	Gastric Carcinoma	GDSC	PPPY	ITCH	620:623	Mutation rewiring degron network	0.1111
p.E612D	ACH-000898	Gastric Cancer	CCLE	PPPY	ITCH	620:623	Mutation rewiring degron network	0.1111
p.T501P	ACH-000703	Lung Cancer	CCLE	LTPPST	DEG_SCF_FBW7_1	500:505	Mutation altering degron motif	0.8142
p.E507K	ACH-001608	Brain Cancer	CCLE	LTPPST	DEG_SCF_FBW7_1	500:505	Mutation rewiring degron network	0.2778

Kaplan plot for LSR in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LSR

UniProt ID: Q86X29

Entrez ID: 51599

Protein name: Lipolysis-stimulated lipoprotein receptor (Angulin-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LSR in