DegronMD

Uniprot ID: Q8IUM7

Source protein: Neuronal PAS domain-containing protein 4

Source gene: NPAS4

Class: DEG_SCF_FBW7_1

Location: 501:506

E3 ligase: FBXW7

DEGRON score: 0.9837

ASA_SCORE: 57.5333

COIL: 0.9027

CONS_SCORE: 0.3268

DSS_SCORE: 0.5539

HELIX: 0.0495

FCONS_SCORE: 1.1078

RIG_SCORE: 0.7385

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q500R	TCGA-49-AARN	LUAD	TCGA	LTPCTS	DEG_SCF_FBW7_1	0.3056
p.Q500R	DO218923	LUAD	ICGC	LTPCTS	DEG_SCF_FBW7_1	0.3056
p.T505I	TCGA-50-5931	LUAD	TCGA	LTPCTS	DEG_SCF_FBW7_1	0.5966
p.T505I	DO24980	LUAD	ICGC	LTPCTS	DEG_SCF_FBW7_1	0.5966
p.E498V	TCGA-77-7337	LUSC	TCGA	LTPCTS	DEG_SCF_FBW7_1	0.25
p.E498V	DO27445	LUSC	ICGC	LTPCTS	DEG_SCF_FBW7_1	0.25
p.T516I	TCGA-A5-A0G2	UCEC	TCGA	LTPCTS	DEG_SCF_FBW7_1	0.0556
p.T516I	DO41235	UCEC	ICGC	LTPCTS	DEG_SCF_FBW7_1	0.0556
p.E498Q	TCGA-E2-A1LG	BRCA	TCGA	LTPCTS	DEG_SCF_FBW7_1	0.25
p.E498Q	DO4018	BRCA	ICGC	LTPCTS	DEG_SCF_FBW7_1	0.25
p.P503S	TCGA-EE-A2MR	SKCM	TCGA	LTPCTS	DEG_SCF_FBW7_1	0.6752
p.P503S	DO37819	SKCM	ICGC	LTPCTS	DEG_SCF_FBW7_1	0.6752
p.P503L	TCGA-EE-A2MR	SKCM	TCGA	LTPCTS	DEG_SCF_FBW7_1	0.7582
p.P503L	DO37819	SKCM	ICGC	LTPCTS	DEG_SCF_FBW7_1	0.7582
p.D499H	DO1094	BRCA	ICGC	LTPCTS	DEG_SCF_FBW7_1	0.2778
p.P509S	SIDM00545	Melanoma	GDSC	LTPCTS	DEG_SCF_FBW7_1	0.25
p.P509S	ACH-000987	Skin Cancer	CCLE	LTPCTS	DEG_SCF_FBW7_1	0.25
p.P509S	Mewo	skin	COSMIC	LTPCTS	DEG_SCF_FBW7_1	0.25
p.S493L	SIDM01106	Melanoma	GDSC	LTPCTS	DEG_SCF_FBW7_1	0.1111
p.S493L	ACH-000822	Skin Cancer	CCLE	LTPCTS	DEG_SCF_FBW7_1	0.1111
p.S493L	SK-MEL-24	skin	COSMIC	LTPCTS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IUM7	Neuronal PAS domain-containing protein 4	DEG_SCF_FBW7_1	501:506	LTPCTS	FBXW7	0.9837	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons