DegronMD

Uniprot ID: Q8IUM7

Source protein: Neuronal PAS domain-containing protein 4

Source gene: NPAS4

Class: DEG_SCF_FBW7_1

Location: 448:454

E3 ligase: FBXW7

DEGRON score: 0.9774

ASA_SCORE: 76.4429

COIL: 0.8839

CONS_SCORE: 0.2819

DSS_SCORE: 0.6138

HELIX: 0.0957

FCONS_SCORE: 0.8919

RIG_SCORE: 0.6764

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S452F	TCGA-D3-A8GM	SKCM	TCGA	LPTPSST	DEG_SCF_FBW7_1	0.6871
p.S452F	DO50288	SKCM	ICGC	LPTPSST	DEG_SCF_FBW7_1	0.6871
p.S452F	SIDM00140	Melanoma	GDSC	LPTPSST	DEG_SCF_FBW7_1	0.6871
p.S452F	ACH-000968	Skin Cancer	CCLE	LPTPSST	DEG_SCF_FBW7_1	0.6871
p.S452F	COLO-792	skin	COSMIC	LPTPSST	DEG_SCF_FBW7_1	0.6871
p.L455F	TCGA-DA-A3F5	SKCM	TCGA	LPTPSST	DEG_SCF_FBW7_1	0.3056
p.L455F	DO37435	SKCM	ICGC	LPTPSST	DEG_SCF_FBW7_1	0.3056
p.T450I	TCGA-E6-A1LX	UCEC	TCGA	LPTPSST	DEG_SCF_FBW7_1	0.7078
p.T450I	TCGA-FW-A3R5	SKCM	TCGA	LPTPSST	DEG_SCF_FBW7_1	0.7078
p.T450I	DO37406	SKCM	ICGC	LPTPSST	DEG_SCF_FBW7_1	0.7078
p.T450I	DO41020	UCEC	ICGC	LPTPSST	DEG_SCF_FBW7_1	0.7078
p.T450I	SIDM00447	B-Lymphoblastic Leukemia	GDSC	LPTPSST	DEG_SCF_FBW7_1	0.7078
p.T450I	ACH-000960	Leukemia	CCLE	LPTPSST	DEG_SCF_FBW7_1	0.7078
p.T450I	REH	haematopoietic_and_lymphoid_tissue	COSMIC	LPTPSST	DEG_SCF_FBW7_1	0.7078
p.F438L	TCGA-VS-A8Q8	CESC	TCGA	LPTPSST	DEG_SCF_FBW7_1	0.0556
p.F438L	DO51625	CESC	ICGC	LPTPSST	DEG_SCF_FBW7_1	0.0556
p.T454A	DO233663	GACA	ICGC	LPTPSST	DEG_SCF_FBW7_1	0.7139
p.S453I	DO229028	LICA	ICGC	LPTPSST	DEG_SCF_FBW7_1	0.623
p.P443L	DO220893	MELA	ICGC	LPTPSST	DEG_SCF_FBW7_1	0.1944
p.P461L	DO222662	MELA	ICGC	LPTPSST	DEG_SCF_FBW7_1	0.1389
p.P451L	DO222843	MELA	ICGC	LPTPSST	DEG_SCF_FBW7_1	0.7582
p.S453C	DO27887	ORCA	ICGC	LPTPSST	DEG_SCF_FBW7_1	0.643
p.P449H	ACH-000901	Lung Cancer	CCLE	LPTPSST	DEG_SCF_FBW7_1	0.6583
p.E442Q	ACH-001513	Cervical Cancer	CCLE	LPTPSST	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IUM7	Neuronal PAS domain-containing protein 4	DEG_SCF_FBW7_1	448:454	LPTPSST	FBXW7	0.9774	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons