DegronMD

Uniprot ID: Q8IUM7

Source protein: Neuronal PAS domain-containing protein 4

Source gene: NPAS4

Class: DEG_COP1_1

Location: 599:609

E3 ligase: COP1

DEGRON score: 0.9725

ASA_SCORE: 69.5545

COIL: 0.8373

CONS_SCORE: 0.5124

DSS_SCORE: 0.3304

HELIX: 0.0467

FCONS_SCORE: 1.0265

RIG_SCORE: 0.77

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S599F	TCGA-18-3409	LUSC	TCGA	SVDVPLVPEGL	DEG_COP1_1	0.7982
p.S599F	DO26444	LUSC	ICGC	SVDVPLVPEGL	DEG_COP1_1	0.7982
p.A592G	TCGA-66-2756	LUSC	TCGA	SVDVPLVPEGL	DEG_COP1_1	0.1389
p.A592G	DO27128	LUSC	ICGC	SVDVPLVPEGL	DEG_COP1_1	0.1389
p.R595W	TCGA-AO-A0JF	BRCA	TCGA	SVDVPLVPEGL	DEG_COP1_1	0.2222
p.R595W	TCGA-CJ-4640	KIRC	TCGA	SVDVPLVPEGL	DEG_COP1_1	0.2222
p.R595W	TCGA-DM-A0XF	COAD	TCGA	SVDVPLVPEGL	DEG_COP1_1	0.2222
p.R595W	TCGA-E9-A5FK	BRCA	TCGA	SVDVPLVPEGL	DEG_COP1_1	0.2222
p.R595W	DO44192	BRCA	ICGC	SVDVPLVPEGL	DEG_COP1_1	0.2222
p.R595W	DO2533	BRCA	ICGC	SVDVPLVPEGL	DEG_COP1_1	0.2222
p.R595W	DO9258	COAD	ICGC	SVDVPLVPEGL	DEG_COP1_1	0.2222
p.R595W	DO16202	KIRC	ICGC	SVDVPLVPEGL	DEG_COP1_1	0.2222
p.P597S	TCGA-AP-A0LM	UCEC	TCGA	SVDVPLVPEGL	DEG_COP1_1	0.2778
p.P597S	DO222655	BTCA	ICGC	SVDVPLVPEGL	DEG_COP1_1	0.2778
p.P597S	DO43306	UCEC	ICGC	SVDVPLVPEGL	DEG_COP1_1	0.2778
p.R595Q	TCGA-CN-A63U	HNSC	TCGA	SVDVPLVPEGL	DEG_COP1_1	0.2222
p.R595Q	DO227549	COCA	ICGC	SVDVPLVPEGL	DEG_COP1_1	0.2222
p.R595Q	DO44454	HNSC	ICGC	SVDVPLVPEGL	DEG_COP1_1	0.2222
p.P606A	TCGA-EB-A4IS	SKCM	TCGA	SVDVPLVPEGL	DEG_COP1_1	0.7503
p.P606A	DO47281	SKCM	ICGC	SVDVPLVPEGL	DEG_COP1_1	0.7503
p.P616L	TCGA-EE-A180	SKCM	TCGA	SVDVPLVPEGL	DEG_COP1_1	0.1389
p.P616L	DO47537	SKCM	ICGC	SVDVPLVPEGL	DEG_COP1_1	0.1389
p.L609M	DO234199	ESAD	ICGC	SVDVPLVPEGL	DEG_COP1_1	0.5999
p.V600M	SIDM01007	T-Lymphoblastic Leukemia	GDSC	SVDVPLVPEGL	DEG_COP1_1	0.6097
p.V600M	ACH-002256	Leukemia	CCLE	SVDVPLVPEGL	DEG_COP1_1	0.6097
p.V600M	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	SVDVPLVPEGL	DEG_COP1_1	0.6097
p.E607K	SIDM00892	Breast Carcinoma	GDSC	SVDVPLVPEGL	DEG_COP1_1	0.7022
p.E607K	ACH-000818	Breast Cancer	CCLE	SVDVPLVPEGL	DEG_COP1_1	0.7022
p.E607K	BT-483	breast	COSMIC	SVDVPLVPEGL	DEG_COP1_1	0.7022
p.Q593K	SIDM00622	Glioblastoma	GDSC	SVDVPLVPEGL	DEG_COP1_1	0.1667
p.Q593K	ACH-002224	Brain Cancer	CCLE	SVDVPLVPEGL	DEG_COP1_1	0.1667
p.Q593K	D-247MG	central_nervous_system	COSMIC	SVDVPLVPEGL	DEG_COP1_1	0.1667
p.L598P	ACH-000975	Lung Cancer	CCLE	SVDVPLVPEGL	DEG_COP1_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SVDVPLVPEGL

Degron related mutations and impact score

Drug responses associated with NPAS4 mutations

All proteins holding degron of SVDVPLVPEGL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IUM7	Neuronal PAS domain-containing protein 4	DEG_COP1_1	599:609	SVDVPLVPEGL	COP1	0.9725	More...