DegronMD

Uniprot ID: Q8IUM7

Source protein: Neuronal PAS domain-containing protein 4

Source gene: NPAS4

Class: DEG_SCF_FBW7_1

Location: 420:427

E3 ligase: FBXW7

DEGRON score: 0.9948

ASA_SCORE: 60.9125

COIL: 0.8678

CONS_SCORE: 0.4902

DSS_SCORE: 0.3816

HELIX: 0.0328

FCONS_SCORE: 1.0961

RIG_SCORE: 0.7274

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G432V	TCGA-61-1740	OV	TCGA	LVCTPPYT	DEG_SCF_FBW7_1	0.1944
p.G432V	DO27981	OV	ICGC	LVCTPPYT	DEG_SCF_FBW7_1	0.1944
p.A435D	TCGA-86-7701	LUAD	TCGA	LVCTPPYT	DEG_SCF_FBW7_1	0.1111
p.A435D	DO24441	LUAD	ICGC	LVCTPPYT	DEG_SCF_FBW7_1	0.1111
p.C434W	TCGA-86-8073	LUAD	TCGA	LVCTPPYT	DEG_SCF_FBW7_1	0.1389
p.C434W	DO23624	LUAD	ICGC	LVCTPPYT	DEG_SCF_FBW7_1	0.1389
p.T423I	TCGA-AP-A056	UCEC	TCGA	LVCTPPYT	DEG_SCF_FBW7_1	0.7078
p.T423I	DO43971	UCEC	ICGC	LVCTPPYT	DEG_SCF_FBW7_1	0.7078
p.P410S	TCGA-BR-7704	STAD	TCGA	LVCTPPYT	DEG_SCF_FBW7_1	0.0556
p.P410S	DO233869	GACA	ICGC	LVCTPPYT	DEG_SCF_FBW7_1	0.0556
p.P410S	DO38360	STAD	ICGC	LVCTPPYT	DEG_SCF_FBW7_1	0.0556
p.D419N	TCGA-FS-A1ZK	SKCM	TCGA	LVCTPPYT	DEG_SCF_FBW7_1	0.3056
p.D419N	DO229462	SKCA	ICGC	LVCTPPYT	DEG_SCF_FBW7_1	0.3056
p.D419N	DO37474	SKCM	ICGC	LVCTPPYT	DEG_SCF_FBW7_1	0.3056
p.P425L	TCGA-GF-A6C9	SKCM	TCGA	LVCTPPYT	DEG_SCF_FBW7_1	0.6471
p.P425L	DO51254	SKCM	ICGC	LVCTPPYT	DEG_SCF_FBW7_1	0.6471
p.P424S	TCGA-W3-A824	SKCM	TCGA	LVCTPPYT	DEG_SCF_FBW7_1	0.6752
p.P424S	DO51271	SKCM	ICGC	LVCTPPYT	DEG_SCF_FBW7_1	0.6752
p.P424L	TCGA-W3-A824	SKCM	TCGA	LVCTPPYT	DEG_SCF_FBW7_1	0.7582
p.P424L	DO51271	SKCM	ICGC	LVCTPPYT	DEG_SCF_FBW7_1	0.7582
p.T427M	DO224897	BRCA	ICGC	LVCTPPYT	DEG_SCF_FBW7_1	0.7423
p.L420I	DO233550	PRAD	ICGC	LVCTPPYT	DEG_SCF_FBW7_1	0.6063

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IUM7	Neuronal PAS domain-containing protein 4	DEG_SCF_FBW7_1	420:427	LVCTPPYT	FBXW7	0.9948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons