DegronMD

Uniprot ID: Q8N9H9

Source protein: Uncharacterized protein C1orf127

Source gene: C1orf127

Class: DEG_SIAH_1

Location: 225:233

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9803

ASA_SCORE: 69.6

COIL: 0.9556

CONS_SCORE: 0.2428

DSS_SCORE: 0.7168

HELIX: 0.0171

FCONS_SCORE: 0.8415

RIG_SCORE: 0.5666

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R229T	TCGA-13-0884	OV	TCGA	TPPAGVPPA	DEG_SIAH_1	0.7876
p.R229T	DO28913	OV	ICGC	TPPAGVPPA	DEG_SIAH_1	0.7876
p.P222L	TCGA-63-A5MT	LUSC	TCGA	TPPAGVPPA	DEG_SIAH_1	0.25
p.P222L	DO219163	LUSC	ICGC	TPPAGVPPA	DEG_SIAH_1	0.25
p.P222L	SIDM00479	Esophageal Carcinoma	GDSC	TPPAGVPPA	DEG_SIAH_1	0.25
p.P222L	ACH-000679	Esophageal Cancer	CCLE	TPPAGVPPA	DEG_SIAH_1	0.25
p.T218I	TCGA-DA-A1HV	SKCM	TCGA	TPPAGVPPA	DEG_SIAH_1	0.1389
p.T218I	DO37659	SKCM	ICGC	TPPAGVPPA	DEG_SIAH_1	0.1389
p.E231K	TCGA-EE-A2GI	SKCM	TCGA	TPPAGVPPA	DEG_SIAH_1	0.7022
p.E231K	DO37410	SKCM	ICGC	TPPAGVPPA	DEG_SIAH_1	0.7022
p.L227F	TCGA-EY-A1G8	UCEC	TCGA	TPPAGVPPA	DEG_SIAH_1	0.6981
p.L227F	DO43578	UCEC	ICGC	TPPAGVPPA	DEG_SIAH_1	0.6981
p.L242P	TCGA-JY-A6FE	ESCA	TCGA	TPPAGVPPA	DEG_SIAH_1	0.0833
p.V219I	DO233254	GACA	ICGC	TPPAGVPPA	DEG_SIAH_1	0.1667
p.Q224K	DO229028	LICA	ICGC	TPPAGVPPA	DEG_SIAH_1	0.3056
p.L226F	DO51521	PACA	ICGC	TPPAGVPPA	DEG_SIAH_1	0.6981
p.E231D	SIDM00794	Other Solid Cancers	GDSC	TPPAGVPPA	DEG_SIAH_1	0.6758
p.W230C	ACH-001540	Liposarcoma	CCLE	TPPAGVPPA	DEG_SIAH_1	0.7

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N9H9	Uncharacterized protein C1orf127	DEG_SIAH_1	225:233	TPPAGVPPA	SIAH1,SIAH2,SIAH3	0.9803	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons