DegronMD

Uniprot ID: Q8N9H9

Source protein: Uncharacterized protein C1orf127

Source gene: C1orf127

Class: DEG_SPOP_SBC_1

Location: 583:587

E3 ligase: SPOP

DEGRON score: 0.9833

ASA_SCORE: 84.02

COIL: 0.952

CONS_SCORE: 0.2237

DSS_SCORE: 0.5639

HELIX: 0.0134

FCONS_SCORE: 0.9579

RIG_SCORE: 0.6697

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q589K	TCGA-E2-A1IN	BRCA	TCGA	AHTSS	DEG_SPOP_SBC_1	0.2778
p.Q589K	DO3134	BRCA	ICGC	AHTSS	DEG_SPOP_SBC_1	0.2778
p.P590S	DO220358	KICH	ICGC	AHTSS	DEG_SPOP_SBC_1	0.25
p.R596W	SIDM00217	Colorectal Carcinoma	GDSC	AHTSS	DEG_SPOP_SBC_1	0.0833
p.R596W	ACH-000999	Colon/Colorectal Cancer	CCLE	AHTSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55197	Protein AF-10	DEG_SPOP_SBC_1	299:303	AHTSS	SPOP	0.9984	More...
Q5TH69	Brefeldin A-inhibited guanine nucleotide-exchange protein 3	DEG_SPOP_SBC_1	280:284	AHTSS	SPOP	0.532	More...
Q9C0C7	Activating molecule in BECN1-regulated autophagy protein 1	DEG_SPOP_SBC_1	1201:1205	AHTSS	SPOP	0.9814	More...
Q9Y6Y8	SEC23-interacting protein	DEG_SPOP_SBC_1	891:895	AHTSS	SPOP	0.9839	More...
Q8N9H9	Uncharacterized protein C1orf127	DEG_SPOP_SBC_1	583:587	AHTSS	SPOP	0.9833	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons