DegronMD - Q9Y6Y8(SEC23IP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S90R	TCGA-42-2587	OV	TCGA	VSSSS	DEG_SPOP_SBC_1	86:90	Mutation altering degron motif	0.7427
p.S90R	DO32439	OV	ICGC	VSSSS	DEG_SPOP_SBC_1	86:90	Mutation altering degron motif	0.7427
p.T896I	TCGA-4J-AA1J	CESC	TCGA	AHTSS	DEG_SPOP_SBC_1	891:895	Mutation rewiring degron network	0.3056
p.N7Y	TCGA-85-8481	LUSC	TCGA	ASTSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1667
p.N7Y	DO45465	LUSC	ICGC	ASTSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1667
p.S88N	TCGA-BG-A220	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	86:90	Mutation altering degron motif	0.7069
p.S88N	DO41784	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	86:90	Mutation altering degron motif	0.7069
p.N95D	TCGA-BR-4368	STAD	TCGA	VSSSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.1944
p.N95D	DO38715	STAD	ICGC	VSSSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.1944
p.S18L	TCGA-BT-A2LB	BLCA	TCGA	ASTSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.3056
p.L156V	TCGA-CN-4740	HNSC	TCGA	PPSY	ITCH	164:167	Mutation rewiring degron network	0.1111
p.L156V	DO14846	HNSC	ICGC	PPSY	ITCH	164:167	Mutation rewiring degron network	0.1111
p.S166L	TCGA-D3-A2JF	SKCM	TCGA	PPSY	ITCH	164:167	Mutation altering degron motif	0.6556
p.S166L	DO38153	SKCM	ICGC	PPSY	ITCH	164:167	Mutation altering degron motif	0.6556
p.S99L	TCGA-DF-A2KU	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.0833
p.S99L	DO223286	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.0833
p.Q85R	TCGA-DK-A6AW	BLCA	TCGA	VSSSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.3056
p.Q85R	DO48566	BLCA	ICGC	VSSSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.3056
p.Q85R	SIDM00611	Kidney Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.3056
p.Q85R	ACH-000684	Kidney Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.3056
p.Q85R	KMRC-1	kidney	COSMIC	VSSSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.3056
p.G12A	TCGA-EO-A3AU	UCEC	TCGA	ASTSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.3056
p.G12A	DO43827	UCEC	ICGC	ASTSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.3056
p.Q85E	TCGA-K4-A83P	BLCA	TCGA	VSSSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.3056
p.Q85E	DO49787	BLCA	ICGC	VSSSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.3056
p.N7H	TCGA-KM-8639	KICH	TCGA	ASTSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1667
p.N7H	DO220363	KICH	ICGC	ASTSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1667
p.S154T	TCGA-L5-A8NS	ESCA	TCGA	PPSY	ITCH	164:167	Mutation rewiring degron network	0.0556
p.S27L	TCGA-LP-A5U2	CESC	TCGA	ASTSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.0556
p.S27L	DO51610	CESC	ICGC	ASTSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.0556
p.E726D	TCGA-OR-A5KB	ACC	TCGA	AATST	DEG_SPOP_SBC_1	718:722	Mutation rewiring degron network	0.2222
p.E97D	DO2605	BRCA	ICGC	VSSSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.1389
p.S84Y	DO230343	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.2778
p.Q98H	DO222884	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.1111
p.P100S	DO233760	GACA	ICGC	VSSSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.0556
p.K160E	DO233876	GACA	ICGC	PPSY	ITCH	164:167	Mutation rewiring degron network	0.2222
p.D723Y	DO229019	LICA	ICGC	AATST	DEG_SPOP_SBC_1	718:722	Mutation blocking ubiquitination signal	0.75
p.D723Y	DO229036	LICA	ICGC	AATST	DEG_SPOP_SBC_1	718:722	Mutation blocking ubiquitination signal	0.75
p.G169E	DO50970	LICA	ICGC	PPSY	ITCH	164:167	Mutation rewiring degron network	0.2778
p.P6T	DO23130	LINC	ICGC	ASTSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1389
p.G19D	DO45299	LIRI	ICGC	ASTSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.2778
p.F168L	DO228221	MALY	ICGC	PPSY	ITCH	164:167	Mutation rewiring degron network	0.3056
p.P175L	DO220891	MELA	ICGC	PPSY	ITCH	164:167	Mutation rewiring degron network	0.1111
p.P176S	DO222753	MELA	ICGC	PPSY	ITCH	164:167	Mutation rewiring degron network	0.0833
p.P92S	DO222837	MELA	ICGC	VSSSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.2778
p.L12I	DO50676	ORCA	ICGC	ASTSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.3056
p.P10H	DO46473	OV	ICGC	ASTSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.25
p.S719F	DO48546	SKCM	ICGC	AATST	DEG_SPOP_SBC_1	718:722	Mutation altering degron motif	0.7982
p.L85I	DO47299	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.3056
p.E158K	DO37766	SKCM	ICGC	PPSY	ITCH	164:167	Mutation rewiring degron network	0.1667
p.E722D	DO219774	UCEC	ICGC	AATST	DEG_SPOP_SBC_1	718:722	Mutation altering degron motif	0.6758
p.D81N	DO41331	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.1944
p.A719T	SIDM02050	Colorectal Carcinoma	GDSC	AATST	DEG_SPOP_SBC_1	718:722	Mutation altering degron motif	0.6028
p.Q85K	SIDM00933	Breast Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.3056
p.Q85K	ACH-000856	Breast Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.3056
p.Q85K	CAL-51	breast	COSMIC	VSSSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.3056
p.A718T	SIDM00572	Gastric Carcinoma	GDSC	AATST	DEG_SPOP_SBC_1	718:722	Mutation altering degron motif	0.7139
p.A718T	ACH-000911	Gastric Cancer	CCLE	AATST	DEG_SPOP_SBC_1	718:722	Mutation altering degron motif	0.7139
p.A718T	NUGC-3	stomach	COSMIC	AATST	DEG_SPOP_SBC_1	718:722	Mutation altering degron motif	0.7139
p.F24L	SIDM01007	T-Lymphoblastic Leukemia	GDSC	ASTSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1389
p.F24L	ACH-002256	Leukemia	CCLE	ASTSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1389
p.F24L	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	ASTSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1389
p.A718V	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	AATST	DEG_SPOP_SBC_1	718:722	Mutation altering degron motif	0.5825
p.A718V	SIDM01173	Rhabdomyosarcoma	GDSC	AATST	DEG_SPOP_SBC_1	718:722	Mutation altering degron motif	0.5825
p.A718V	SIDM01686	Chronic Myelogenous Leukemia	GDSC	AATST	DEG_SPOP_SBC_1	718:722	Mutation altering degron motif	0.5825
p.K5R	SIDM00980	Gastric Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	13:17	Mutation substituting flanking lysine	0.2222
p.K5R	ACH-000948	Gastric Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	13:17	Mutation substituting flanking lysine	0.2222
p.K5R	23132-87	stomach	COSMIC	ASTSS	DEG_SPOP_SBC_1	13:17	Mutation substituting flanking lysine	0.2222
p.S26F	SIDM01554	Mesothelioma	GDSC	ASTSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.0833
p.S26F	ACH-000331	Lung Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.0833
p.P157T	ACH-001458	Colon/Colorectal Cancer	CCLE	PPSY	ITCH	164:167	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SEC23IP

UniProt ID: Q9Y6Y8

Entrez ID: 11196

Protein name: SEC23-interacting protein (p125)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SEC23IP in