DegronMD

Uniprot ID: P55197

Source protein: Protein AF-10

Source gene: MLLT10

Class: DEG_COP1_1

Location: 250:259

E3 ligase: COP1

DEGRON score: 0.9656

ASA_SCORE: 84.69

COIL: 0.9127

CONS_SCORE: 0.3723

DSS_SCORE: 0.6832

HELIX: 0.033

FCONS_SCORE: 0.9722

RIG_SCORE: 0.6451

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T260N	TCGA-22-5481	LUSC	TCGA	EPSPALVPSL	DEG_COP1_1	0.3056
p.T260N	DO27160	LUSC	ICGC	EPSPALVPSL	DEG_COP1_1	0.3056
p.E264G	TCGA-AP-A0LM	UCEC	TCGA	EPSPALVPSL	DEG_COP1_1	0.1944
p.E264G	DO43306	UCEC	ICGC	EPSPALVPSL	DEG_COP1_1	0.1944
p.Y267C	TCGA-CA-6717	COAD	TCGA	EPSPALVPSL	DEG_COP1_1	0.1111
p.Y267C	DO8264	COAD	ICGC	EPSPALVPSL	DEG_COP1_1	0.1111
p.K242T	TCGA-EO-A22X	UCEC	TCGA	EPSPALVPSL	DEG_COP1_1	0.2222
p.K242T	DO43907	UCEC	ICGC	EPSPALVPSL	DEG_COP1_1	0.2222
p.L255F	TCGA-ER-A1A1	SKCM	TCGA	EPSPALVPSL	DEG_COP1_1	0.587
p.L255F	DO37413	SKCM	ICGC	EPSPALVPSL	DEG_COP1_1	0.587
p.A254S	DO228978	LICA	ICGC	EPSPALVPSL	DEG_COP1_1	0.6477
p.V256F	DO229028	LICA	ICGC	EPSPALVPSL	DEG_COP1_1	0.7068

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55197	Protein AF-10	DEG_COP1_1	250:259	EPSPALVPSL	COP1	0.9656	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons