DegronMD - Q9UMS6(SYNPO2)

FUNCTION: Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:24005909, PubMed:23225103). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may pl... FUNCTION: Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:24005909, PubMed:23225103). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. View more >>

GO - Biological processes (BP): autophagosome assembly [GO:0000045]; chaperone-mediated autophagy [GO:0061684]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of cell migration [GO:0030335]; regulation of Rho-dependent protein serine/threonine kinase activity [GO:2000298]

GO - Molecular function (MF): 14-3-3 protein binding [GO:0071889]; actin binding [GO:0003779]; alpha-actinin binding [GO:0051393]; filamin binding [GO:0031005]; muscle alpha-actinin binding [GO:0051371]; protein-macromolecule adaptor activity [GO:0030674]

GO - Cellular component (CC): actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; stress fiber [GO:0001725]; vesicle tethering complex [GO:0099023]; Z disc [GO:0030018]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T517M	DO229389	BTCA	ICGC	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation altering degron motif	0.8534
p.T517M	DO227990	COCA	ICGC	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation altering degron motif	0.8534
p.S519C	TCGA-05-4417	LUAD	TCGA	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation altering degron motif	0.7541
p.S519C	DO23570	LUAD	ICGC	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation altering degron motif	0.7541
p.T770S	NCI-H128	lung	COSMIC	VKSSS	DEG_SPOP_SBC_1	765:769	Mutation blocking phosphorylation signal	0.75
p.S519R	TCGA-A6-5661	COAD	TCGA	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation altering degron motif	0.7427
p.S519R	DO8634	COAD	ICGC	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation altering degron motif	0.7427
p.P621L	SIDM00893	Breast Carcinoma	GDSC	PPPY	ITCH	619:622	Mutation altering degron motif	0.6471
p.P621L	ACH-000536	Breast Cancer	CCLE	PPPY	ITCH	619:622	Mutation altering degron motif	0.6471
p.P621L	BT-20	breast	COSMIC	PPPY	ITCH	619:622	Mutation altering degron motif	0.6471
p.T755I	TCGA-AA-A00N	COAD	TCGA	VKSSS	DEG_SPOP_SBC_1	765:769	Mutation blocking phosphorylation signal	0.5
p.T755I	DO9876	COAD	ICGC	VKSSS	DEG_SPOP_SBC_1	765:769	Mutation blocking phosphorylation signal	0.5
p.P755S	Mewo	skin	COSMIC	VKSSS	DEG_SPOP_SBC_1	765:769	Mutation blocking phosphorylation signal	0.5
p.A618S	DO229045	LICA	ICGC	PPPY	ITCH	619:622	Mutation rewiring degron network	0.3056
p.A764V	DO220865	MELA	ICGC	VKSSS	DEG_SPOP_SBC_1	765:769	Mutation rewiring degron network	0.3056
p.K509Q	DO46342	OV	ICGC	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation substituting flanking lysine	0.3056
p.K509Q	SIDM01611	Endometrial Carcinoma	GDSC	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation substituting flanking lysine	0.3056
p.K509Q	ACH-000996	Endometrial/Uterine Cancer	CCLE	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation substituting flanking lysine	0.3056
p.D523Y	TCGA-86-A4JF	LUAD	TCGA	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation rewiring degron network	0.2778
p.D523Y	DO222545	ESCA	ICGC	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation rewiring degron network	0.2778

Showing 1 to 20 of 73 entries

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No resistance data available for this Degron.

Kaplan plot for SYNPO2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SYNPO2

UniProt ID: Q9UMS6

Entrez ID: 171024

Protein name: Synaptopodin-2 (Genethonin-2) (Myopodin)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for SYNPO2 in