DegronMD - Q9UMS6(SYNPO2)

FUNCTION: Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:24005909, PubMed:23225103). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q91YE8, ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:23225103, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213, ECO:0000305|PubMed:16885336, ECO:0000305|PubMed:20554076}.; FUNCTION: [Isoform 1]: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 2]: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 3]: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 4]: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. {ECO:0000269|PubMed:24005909}.; FUNCTION: [Isoform 5]: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. {ECO:0000269|PubMed:22915763, ECO:0000269|PubMed:24005909, ECO:0000269|PubMed:25883213}. View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S519C	TCGA-05-4417	LUAD	TCGA	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation altering degron motif	0.7541
p.S519C	DO23570	LUAD	ICGC	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation altering degron motif	0.7541
p.R531I	TCGA-06-5416	GBM	TCGA	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation rewiring degron network	0.0556
p.R531I	DO10880	GBM	ICGC	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation rewiring degron network	0.0556
p.V759L	TCGA-50-5930	LUAD	TCGA	VKSSS	DEG_SPOP_SBC_1	765:769	Mutation rewiring degron network	0.1667
p.V759L	DO25189	LUAD	ICGC	VKSSS	DEG_SPOP_SBC_1	765:769	Mutation rewiring degron network	0.1667
p.D523Y	TCGA-86-A4JF	LUAD	TCGA	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation rewiring degron network	0.2778
p.D523Y	DO222545	ESCA	ICGC	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation rewiring degron network	0.2778
p.D523Y	DO45317	LUAD	ICGC	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation rewiring degron network	0.2778
p.S519R	TCGA-A6-5661	COAD	TCGA	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation altering degron motif	0.7427
p.S519R	DO8634	COAD	ICGC	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation altering degron motif	0.7427
p.T755I	TCGA-AA-A00N	COAD	TCGA	VKSSS	DEG_SPOP_SBC_1	765:769	Mutation blocking phosphorylation signal	0.5
p.T755I	DO9876	COAD	ICGC	VKSSS	DEG_SPOP_SBC_1	765:769	Mutation blocking phosphorylation signal	0.5
p.A524T	TCGA-AJ-A3EK	UCEC	TCGA	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation rewiring degron network	0.25
p.A524T	DO41584	UCEC	ICGC	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation rewiring degron network	0.25
p.P757H	TCGA-AJ-A3EL	UCEC	TCGA	VKSSS	DEG_SPOP_SBC_1	765:769	Mutation rewiring degron network	0.1111
p.P757H	DO41542	UCEC	ICGC	VKSSS	DEG_SPOP_SBC_1	765:769	Mutation rewiring degron network	0.1111
p.P629L	TCGA-AJ-A8CW	UCEC	TCGA	PPPY	ITCH	619:622	Mutation rewiring degron network	0.1389
p.P629L	DO52400	UCEC	ICGC	PPPY	ITCH	619:622	Mutation rewiring degron network	0.1389
p.E105K	TCGA-AP-A059	UCEC	TCGA	VESTT	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.1111
p.E105K	DO41361	UCEC	ICGC	VESTT	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.1111
p.A631T	TCGA-AP-A059	UCEC	TCGA	PPPY	ITCH	619:622	Mutation rewiring degron network	0.0833
p.A631T	DO41361	UCEC	ICGC	PPPY	ITCH	619:622	Mutation rewiring degron network	0.0833
p.A631T	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	619:622	Mutation rewiring degron network	0.0833
p.A631T	ACH-000438	Lung Cancer	CCLE	PPPY	ITCH	619:622	Mutation rewiring degron network	0.0833
p.A631T	LU-65	lung	COSMIC	PPPY	ITCH	619:622	Mutation rewiring degron network	0.0833
p.G110E	TCGA-AX-A1CE	UCEC	TCGA	VESTT	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.25
p.G110E	DO42280	UCEC	ICGC	VESTT	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.25
p.P629H	TCGA-BB-8601	HNSC	TCGA	PPPY	ITCH	619:622	Mutation rewiring degron network	0.1389
p.P629H	DO14151	HNSC	ICGC	PPPY	ITCH	619:622	Mutation rewiring degron network	0.1389
p.A123V	TCGA-BR-8060	STAD	TCGA	VESTT	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.1667
p.A123V	DO38205	STAD	ICGC	VESTT	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.1667
p.F616V	TCGA-BR-8589	STAD	TCGA	PPPY	ITCH	619:622	Mutation rewiring degron network	0.25
p.F616V	DO47813	STAD	ICGC	PPPY	ITCH	619:622	Mutation rewiring degron network	0.25
p.P612L	TCGA-DA-A1HY	SKCM	TCGA	PPPY	ITCH	619:622	Mutation rewiring degron network	0.1389
p.P612L	DO37409	SKCM	ICGC	PPPY	ITCH	619:622	Mutation rewiring degron network	0.1389
p.P617S	TCGA-EB-A6QY	SKCM	TCGA	PPPY	ITCH	619:622	Mutation rewiring degron network	0.2778
p.P617S	DO48702	SKCM	ICGC	PPPY	ITCH	619:622	Mutation rewiring degron network	0.2778
p.E510K	TCGA-EE-A3AG	SKCM	TCGA	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation rewiring degron network	0.2222
p.E510K	DO37471	SKCM	ICGC	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation rewiring degron network	0.2222
p.Q508K	TCGA-ER-A1A1	SKCM	TCGA	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation rewiring degron network	0.1667
p.Q508K	DO37413	SKCM	ICGC	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation rewiring degron network	0.1667
p.D512E	TCGA-JW-AAVH	CESC	TCGA	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation rewiring degron network	0.2778
p.D512E	DO51605	CESC	ICGC	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation rewiring degron network	0.2778
p.R121Q	TCGA-W3-AA1Q	SKCM	TCGA	VESTT	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.2222
p.R121Q	DO233624	GACA	ICGC	VESTT	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.2222
p.R121Q	DO219487	SKCM	ICGC	VESTT	DEG_SPOP_SBC_1	113:117	Mutation rewiring degron network	0.2222
p.T517M	DO229389	BTCA	ICGC	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation altering degron motif	0.8534
p.T517M	DO227990	COCA	ICGC	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation altering degron motif	0.8534
p.A631S	DO230334	COCA	ICGC	PPPY	ITCH	619:622	Mutation rewiring degron network	0.0833
p.A631S	DO228978	LICA	ICGC	PPPY	ITCH	619:622	Mutation rewiring degron network	0.0833
p.A618S	DO229045	LICA	ICGC	PPPY	ITCH	619:622	Mutation rewiring degron network	0.3056
p.A760T	DO231549	LINC	ICGC	VKSSS	DEG_SPOP_SBC_1	765:769	Mutation rewiring degron network	0.1944
p.A764V	DO220865	MELA	ICGC	VKSSS	DEG_SPOP_SBC_1	765:769	Mutation rewiring degron network	0.3056
p.A507V	DO222837	MELA	ICGC	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation rewiring degron network	0.1389
p.K509Q	DO46342	OV	ICGC	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation substituting flanking lysine	0.3056
p.K509Q	SIDM01611	Endometrial Carcinoma	GDSC	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation substituting flanking lysine	0.3056
p.K509Q	ACH-000996	Endometrial/Uterine Cancer	CCLE	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation substituting flanking lysine	0.3056
p.Q508P	SIDM00499	Prostate Carcinoma	GDSC	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation rewiring degron network	0.1667
p.Q508P	ACH-000956	Prostate Cancer	CCLE	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation rewiring degron network	0.1667
p.Q508P	22RV1	prostate	COSMIC	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation rewiring degron network	0.1667
p.A525S	SIDM00371	Pancreatic Carcinoma	GDSC	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation rewiring degron network	0.2222
p.A525S	ACH-000652	Pancreatic Cancer	CCLE	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation rewiring degron network	0.2222
p.A525S	SUIT-2	pancreas	COSMIC	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation rewiring degron network	0.2222
p.T527N	SIDM00544	Neuroblastoma	GDSC	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation rewiring degron network	0.1667
p.T527N	GOTO	autonomic ganglia	COSMIC	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation rewiring degron network	0.1667
p.P621L	SIDM00893	Breast Carcinoma	GDSC	PPPY	ITCH	619:622	Mutation altering degron motif	0.6471
p.P621L	ACH-000536	Breast Cancer	CCLE	PPPY	ITCH	619:622	Mutation altering degron motif	0.6471
p.P621L	BT-20	breast	COSMIC	PPPY	ITCH	619:622	Mutation altering degron motif	0.6471
p.T770S	NCI-H128	lung	COSMIC	VKSSS	DEG_SPOP_SBC_1	765:769	Mutation blocking phosphorylation signal	0.75
p.E525K	HCC2998	large intestine	COSMIC	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation rewiring degron network	0.2222
p.E525K	PE/CA-PJ15	upper aerodigestive tract	COSMIC	VGGTPSRE	DEG_SCF_FBW7_2	514:521	Mutation rewiring degron network	0.2222
p.P755S	Mewo	skin	COSMIC	VKSSS	DEG_SPOP_SBC_1	765:769	Mutation blocking phosphorylation signal	0.5

Kaplan plot for SYNPO2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SYNPO2

UniProt ID: Q9UMS6

Entrez ID: 171024

Protein name: Synaptopodin-2 (Genethonin-2) (Myopodin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SYNPO2 in