DegronMD

Uniprot ID: Q9UMS6

Source protein: Synaptopodin-2

Source gene: SYNPO2

Class: DEG_SCF_FBW7_2

Location: 514:521

E3 ligase: FBXW7

DEGRON score: 0.5669

ASA_SCORE: 87.55

COIL: 0.848

CONS_SCORE: 0.4974

DSS_SCORE: 0.7259

HELIX: 0.1154

FCONS_SCORE: 0.8889

RIG_SCORE: 0.6003

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S519C	TCGA-05-4417	LUAD	TCGA	VGGTPSRE	DEG_SCF_FBW7_2	0.7541
p.S519C	DO23570	LUAD	ICGC	VGGTPSRE	DEG_SCF_FBW7_2	0.7541
p.R531I	TCGA-06-5416	GBM	TCGA	VGGTPSRE	DEG_SCF_FBW7_2	0.0556
p.R531I	DO10880	GBM	ICGC	VGGTPSRE	DEG_SCF_FBW7_2	0.0556
p.D523Y	TCGA-86-A4JF	LUAD	TCGA	VGGTPSRE	DEG_SCF_FBW7_2	0.2778
p.D523Y	DO222545	ESCA	ICGC	VGGTPSRE	DEG_SCF_FBW7_2	0.2778
p.D523Y	DO45317	LUAD	ICGC	VGGTPSRE	DEG_SCF_FBW7_2	0.2778
p.S519R	TCGA-A6-5661	COAD	TCGA	VGGTPSRE	DEG_SCF_FBW7_2	0.7427
p.S519R	DO8634	COAD	ICGC	VGGTPSRE	DEG_SCF_FBW7_2	0.7427
p.A524T	TCGA-AJ-A3EK	UCEC	TCGA	VGGTPSRE	DEG_SCF_FBW7_2	0.25
p.A524T	DO41584	UCEC	ICGC	VGGTPSRE	DEG_SCF_FBW7_2	0.25
p.E510K	TCGA-EE-A3AG	SKCM	TCGA	VGGTPSRE	DEG_SCF_FBW7_2	0.2222
p.E510K	DO37471	SKCM	ICGC	VGGTPSRE	DEG_SCF_FBW7_2	0.2222
p.Q508K	TCGA-ER-A1A1	SKCM	TCGA	VGGTPSRE	DEG_SCF_FBW7_2	0.1667
p.Q508K	DO37413	SKCM	ICGC	VGGTPSRE	DEG_SCF_FBW7_2	0.1667
p.D512E	TCGA-JW-AAVH	CESC	TCGA	VGGTPSRE	DEG_SCF_FBW7_2	0.2778
p.D512E	DO51605	CESC	ICGC	VGGTPSRE	DEG_SCF_FBW7_2	0.2778
p.T517M	DO229389	BTCA	ICGC	VGGTPSRE	DEG_SCF_FBW7_2	0.8534
p.T517M	DO227990	COCA	ICGC	VGGTPSRE	DEG_SCF_FBW7_2	0.8534
p.A507V	DO222837	MELA	ICGC	VGGTPSRE	DEG_SCF_FBW7_2	0.1389
p.K509Q	DO46342	OV	ICGC	VGGTPSRE	DEG_SCF_FBW7_2	0.3056
p.K509Q	SIDM01611	Endometrial Carcinoma	GDSC	VGGTPSRE	DEG_SCF_FBW7_2	0.3056
p.K509Q	ACH-000996	Endometrial/Uterine Cancer	CCLE	VGGTPSRE	DEG_SCF_FBW7_2	0.3056
p.Q508P	SIDM00499	Prostate Carcinoma	GDSC	VGGTPSRE	DEG_SCF_FBW7_2	0.1667
p.Q508P	ACH-000956	Prostate Cancer	CCLE	VGGTPSRE	DEG_SCF_FBW7_2	0.1667
p.Q508P	22RV1	prostate	COSMIC	VGGTPSRE	DEG_SCF_FBW7_2	0.1667
p.A525S	SIDM00371	Pancreatic Carcinoma	GDSC	VGGTPSRE	DEG_SCF_FBW7_2	0.2222
p.A525S	ACH-000652	Pancreatic Cancer	CCLE	VGGTPSRE	DEG_SCF_FBW7_2	0.2222
p.A525S	SUIT-2	pancreas	COSMIC	VGGTPSRE	DEG_SCF_FBW7_2	0.2222
p.T527N	SIDM00544	Neuroblastoma	GDSC	VGGTPSRE	DEG_SCF_FBW7_2	0.1667
p.T527N	GOTO	autonomic_ganglia	COSMIC	VGGTPSRE	DEG_SCF_FBW7_2	0.1667
p.E525K	HCC2998	large_intestine	COSMIC	VGGTPSRE	DEG_SCF_FBW7_2	0.2222
p.E525K	PE/CA-PJ15	upper_aerodigestive_tract	COSMIC	VGGTPSRE	DEG_SCF_FBW7_2	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VGGTPSRE

Degron related mutations and impact score

Drug responses associated with SYNPO2 mutations

All proteins holding degron of VGGTPSRE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UMS6	Synaptopodin-2	DEG_SCF_FBW7_2	514:521	VGGTPSRE	FBXW7	0.5669	More...