DegronMD

Uniprot ID: Q9UMS6

Source protein: Synaptopodin-2

Source gene: SYNPO2

Class: DEG_SPOP_SBC_1

Location: 113:117

E3 ligase: SPOP

DEGRON score: 0.9987

ASA_SCORE: 79.26

COIL: 0.763

CONS_SCORE: 0.4908

DSS_SCORE: 0.3976

HELIX: 0.0884

FCONS_SCORE: 1.0426

RIG_SCORE: 0.7764

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E105K	TCGA-AP-A059	UCEC	TCGA	VESTT	DEG_SPOP_SBC_1	0.1111
p.E105K	DO41361	UCEC	ICGC	VESTT	DEG_SPOP_SBC_1	0.1111
p.G110E	TCGA-AX-A1CE	UCEC	TCGA	VESTT	DEG_SPOP_SBC_1	0.25
p.G110E	DO42280	UCEC	ICGC	VESTT	DEG_SPOP_SBC_1	0.25
p.A123V	TCGA-BR-8060	STAD	TCGA	VESTT	DEG_SPOP_SBC_1	0.1667
p.A123V	DO38205	STAD	ICGC	VESTT	DEG_SPOP_SBC_1	0.1667
p.R121Q	TCGA-W3-AA1Q	SKCM	TCGA	VESTT	DEG_SPOP_SBC_1	0.2222
p.R121Q	DO233624	GACA	ICGC	VESTT	DEG_SPOP_SBC_1	0.2222
p.R121Q	DO219487	SKCM	ICGC	VESTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5UIP0	Telomere-associated protein RIF1	DEG_SPOP_SBC_1	1425:1429	VESTT	SPOP	0.9633	More...
Q9UMS6	Synaptopodin-2	DEG_SPOP_SBC_1	113:117	VESTT	SPOP	0.9987	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons