DegronMD - Q5UIP0(RIF1)

FUNCTION: Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphory... View more >>

GO - Biological processes (BP): cell cycle [GO:0007049]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to leukemia inhibitory factor [GO:1990830]; DNA repair [GO:0006281]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of gene expression, ... View more >>

GO - Molecular function (MF):

GO - Cellular component (CC): chromatin [GO:0000785]; chromosome, telomeric repeat region [GO:0140445]; condensed chromosome [GO:0000793]; cytoplasm [GO:0005737]; female pronucleus [GO:0001939]; male pronucleus [GO:0001940]; nuclear body [GO:0016604]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634];... View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1200R	TCGA-19-5956	GBM	TCGA	VVSSS	DEG_SPOP_SBC_1	1196:1200	Mutation altering degron motif	0.8538
p.S1200R	DO13863	GBM	ICGC	VVSSS	DEG_SPOP_SBC_1	1196:1200	Mutation altering degron motif	0.8538
p.T1428I	SIDM01199	Hepatocellular Carcinoma	GDSC	VESTT	DEG_SPOP_SBC_1	1425:1429	Mutation altering degron motif	0.8189
p.T1428I	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	VESTT	DEG_SPOP_SBC_1	1425:1429	Mutation altering degron motif	0.8189
p.T1428I	SIDM01559	Melanoma	GDSC	VESTT	DEG_SPOP_SBC_1	1425:1429	Mutation altering degron motif	0.8189
p.S1427P	SIDM02059	Colorectal Carcinoma	GDSC	VESTT	DEG_SPOP_SBC_1	1425:1429	Mutation altering degron motif	0.7863
p.E1891V	TCGA-B5-A1MX	UCEC	TCGA	PEETPKME	DEG_SCF_FBW7_2	1884:1891	Mutation altering degron motif	0.7693
p.E1891V	DO41999	UCEC	ICGC	PEETPKME	DEG_SCF_FBW7_2	1884:1891	Mutation altering degron motif	0.7693
p.S1818L	TCGA-GN-A26C	SKCM	TCGA	SKENT	DEG_APCC_KENBOX_2	1818:1822	Mutation altering degron motif	0.7667
p.S1818L	DO233733	GACA	ICGC	SKENT	DEG_APCC_KENBOX_2	1818:1822	Mutation altering degron motif	0.7667
p.S1818L	DO37782	SKCM	ICGC	SKENT	DEG_APCC_KENBOX_2	1818:1822	Mutation altering degron motif	0.7667
p.K1819R	TCGA-UY-A78K	BLCA	TCGA	SKENT	DEG_APCC_KENBOX_2	1818:1822	Mutation altering degron motif	0.7237
p.K1819R	DO219031	BLCA	ICGC	SKENT	DEG_APCC_KENBOX_2	1818:1822	Mutation altering degron motif	0.7237
p.K1819R	DO231772	LINC	ICGC	SKENT	DEG_APCC_KENBOX_2	1818:1822	Mutation altering degron motif	0.7237
p.S1431N	TCGA-73-4668	LUAD	TCGA	DKENS	DEG_APCC_KENBOX_2	1433:1437	Mutation blocking phosphorylation signal	0.7222
p.S1431N	TCGA-73-4668	LUAD	TCGA	VESTT	DEG_SPOP_SBC_1	1425:1429	Mutation blocking phosphorylation signal	0.7222
p.S1431N	DO23961	LUAD	ICGC	DKENS	DEG_APCC_KENBOX_2	1433:1437	Mutation blocking phosphorylation signal	0.7222
p.S1431N	DO23961	LUAD	ICGC	VESTT	DEG_SPOP_SBC_1	1425:1429	Mutation blocking phosphorylation signal	0.7222
p.S1194Y	TCGA-A4-7288	KIRP	TCGA	VVSSS	DEG_SPOP_SBC_1	1196:1200	Mutation blocking phosphorylation signal	0.7222
p.S1194Y	TCGA-DF-A2KU	UCEC	TCGA	VVSSS	DEG_SPOP_SBC_1	1196:1200	Mutation blocking phosphorylation signal	0.7222

Showing 1 to 20 of 102 entries

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Kaplan plot for RIF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RIF1

UniProt ID: Q5UIP0

Entrez ID: 55183

Protein name: Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RIF1 in