DegronMD - Q5UIP0(RIF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1444H	TCGA-16-0848	GBM	TCGA	DKENS	DEG_APCC_KENBOX_2	1433:1437	Mutation rewiring degron network	0.1389
p.R1444H	DO12196	GBM	ICGC	DKENS	DEG_APCC_KENBOX_2	1433:1437	Mutation rewiring degron network	0.1389
p.R1416L	TCGA-17-Z043	LUAD	TCGA	VESTT	DEG_SPOP_SBC_1	1425:1429	Mutation rewiring degron network	0.0833
p.S1200R	TCGA-19-5956	GBM	TCGA	VVSSS	DEG_SPOP_SBC_1	1196:1200	Mutation altering degron motif	0.8538
p.S1200R	DO13863	GBM	ICGC	VVSSS	DEG_SPOP_SBC_1	1196:1200	Mutation altering degron motif	0.8538
p.N1387D	TCGA-23-1021	OV	TCGA	SKENT	DEG_APCC_KENBOX_2	1384:1388	Mutation altering degron motif	0.6932
p.N1387D	DO32183	OV	ICGC	SKENT	DEG_APCC_KENBOX_2	1384:1388	Mutation altering degron motif	0.6932
p.S1189F	TCGA-23-1116	OV	TCGA	VVSSS	DEG_SPOP_SBC_1	1196:1200	Mutation blocking phosphorylation signal	0.5833
p.S1189F	DO30050	OV	ICGC	VVSSS	DEG_SPOP_SBC_1	1196:1200	Mutation blocking phosphorylation signal	0.5833
p.L1026V	TCGA-38-4625	LUAD	TCGA	KKENM	DEG_APCC_KENBOX_2	1016:1020	Mutation rewiring degron network	0.1667
p.L1026V	DO23952	LUAD	ICGC	KKENM	DEG_APCC_KENBOX_2	1016:1020	Mutation rewiring degron network	0.1667
p.S1008L	TCGA-55-A48Y	LUAD	TCGA	KKENM	DEG_APCC_KENBOX_2	1016:1020	Mutation blocking phosphorylation signal	0.5556
p.S1008L	DO26160	LUAD	ICGC	KKENM	DEG_APCC_KENBOX_2	1016:1020	Mutation blocking phosphorylation signal	0.5556
p.S1431N	TCGA-73-4668	LUAD	TCGA	DKENS	DEG_APCC_KENBOX_2	1433:1437	Mutation blocking phosphorylation signal	0.7222
p.S1431N	TCGA-73-4668	LUAD	TCGA	VESTT	DEG_SPOP_SBC_1	1425:1429	Mutation blocking phosphorylation signal	0.7222
p.S1431N	DO23961	LUAD	ICGC	DKENS	DEG_APCC_KENBOX_2	1433:1437	Mutation blocking phosphorylation signal	0.7222
p.S1431N	DO23961	LUAD	ICGC	VESTT	DEG_SPOP_SBC_1	1425:1429	Mutation blocking phosphorylation signal	0.7222
p.N1387T	TCGA-A3-3317	KIRC	TCGA	SKENT	DEG_APCC_KENBOX_2	1384:1388	Mutation altering degron motif	0.7055
p.S1194Y	TCGA-A4-7288	KIRP	TCGA	VVSSS	DEG_SPOP_SBC_1	1196:1200	Mutation blocking phosphorylation signal	0.7222
p.S1194Y	TCGA-DF-A2KU	UCEC	TCGA	VVSSS	DEG_SPOP_SBC_1	1196:1200	Mutation blocking phosphorylation signal	0.7222
p.S1194Y	DO20925	KIRP	ICGC	VVSSS	DEG_SPOP_SBC_1	1196:1200	Mutation blocking phosphorylation signal	0.7222
p.S1194Y	DO223286	UCEC	ICGC	VVSSS	DEG_SPOP_SBC_1	1196:1200	Mutation blocking phosphorylation signal	0.7222
p.V1196I	TCGA-A6-2686	COAD	TCGA	VVSSS	DEG_SPOP_SBC_1	1196:1200	Mutation altering degron motif	0.7076
p.V1196I	DO7828	COAD	ICGC	VVSSS	DEG_SPOP_SBC_1	1196:1200	Mutation altering degron motif	0.7076
p.S1814F	TCGA-AG-3892	READ	TCGA	SKENT	DEG_APCC_KENBOX_2	1818:1822	Mutation rewiring degron network	0.2222
p.S1814F	DO36394	READ	ICGC	SKENT	DEG_APCC_KENBOX_2	1818:1822	Mutation rewiring degron network	0.2222
p.R1421C	TCGA-AX-A1CE	UCEC	TCGA	VESTT	DEG_SPOP_SBC_1	1425:1429	Mutation rewiring degron network	0.2222
p.R1421C	TCGA-FI-A2D5	UCEC	TCGA	VESTT	DEG_SPOP_SBC_1	1425:1429	Mutation rewiring degron network	0.2222
p.R1421C	DO42280	UCEC	ICGC	VESTT	DEG_SPOP_SBC_1	1425:1429	Mutation rewiring degron network	0.2222
p.R1421C	DO41331	UCEC	ICGC	VESTT	DEG_SPOP_SBC_1	1425:1429	Mutation rewiring degron network	0.2222
p.N1193H	TCGA-AZ-4315	COAD	TCGA	VVSSS	DEG_SPOP_SBC_1	1196:1200	Mutation rewiring degron network	0.25
p.N1193H	DO8842	COAD	ICGC	VVSSS	DEG_SPOP_SBC_1	1196:1200	Mutation rewiring degron network	0.25
p.N1436T	TCGA-B5-A11E	UCEC	TCGA	DKENS	DEG_APCC_KENBOX_2	1433:1437	Mutation altering degron motif	0.7055
p.N1436T	DO41644	UCEC	ICGC	DKENS	DEG_APCC_KENBOX_2	1433:1437	Mutation altering degron motif	0.7055
p.E1891V	TCGA-B5-A1MX	UCEC	TCGA	PEETPKME	DEG_SCF_FBW7_2	1884:1891	Mutation altering degron motif	0.7693
p.E1891V	DO41999	UCEC	ICGC	PEETPKME	DEG_SCF_FBW7_2	1884:1891	Mutation altering degron motif	0.7693
p.D1433Y	TCGA-BR-4256	STAD	TCGA	DKENS	DEG_APCC_KENBOX_2	1433:1437	Mutation altering degron motif	0.6214
p.D1433Y	DO38743	STAD	ICGC	DKENS	DEG_APCC_KENBOX_2	1433:1437	Mutation altering degron motif	0.6214
p.S1826Y	TCGA-BS-A0TC	UCEC	TCGA	SKENT	DEG_APCC_KENBOX_2	1818:1822	Mutation blocking phosphorylation signal	0.6667
p.S1826Y	DO42400	UCEC	ICGC	SKENT	DEG_APCC_KENBOX_2	1818:1822	Mutation blocking phosphorylation signal	0.6667
p.V1832A	TCGA-DI-A1BU	UCEC	TCGA	SKENT	DEG_APCC_KENBOX_2	1818:1822	Mutation rewiring degron network	0.0556
p.V1832A	DO42023	UCEC	ICGC	SKENT	DEG_APCC_KENBOX_2	1818:1822	Mutation rewiring degron network	0.0556
p.M1020V	TCGA-EO-A22R	UCEC	TCGA	KKENM	DEG_APCC_KENBOX_2	1016:1020	Mutation altering degron motif	0.6097
p.M1020V	DO42713	UCEC	ICGC	KKENM	DEG_APCC_KENBOX_2	1016:1020	Mutation altering degron motif	0.6097
p.S1810L	TCGA-FD-A3B3	BLCA	TCGA	SKENT	DEG_APCC_KENBOX_2	1818:1822	Mutation blocking phosphorylation signal	0.5556
p.S1810L	DO749	BLCA	ICGC	SKENT	DEG_APCC_KENBOX_2	1818:1822	Mutation blocking phosphorylation signal	0.5556
p.S1818L	TCGA-GN-A26C	SKCM	TCGA	SKENT	DEG_APCC_KENBOX_2	1818:1822	Mutation altering degron motif	0.7667
p.S1818L	DO233733	GACA	ICGC	SKENT	DEG_APCC_KENBOX_2	1818:1822	Mutation altering degron motif	0.7667
p.S1818L	DO37782	SKCM	ICGC	SKENT	DEG_APCC_KENBOX_2	1818:1822	Mutation altering degron motif	0.7667
p.K1376N	TCGA-HE-A5NH	KIRP	TCGA	SKENT	DEG_APCC_KENBOX_2	1384:1388	Mutation substituting flanking lysine	0.2222
p.K1376N	DO44485	KIRP	ICGC	SKENT	DEG_APCC_KENBOX_2	1384:1388	Mutation substituting flanking lysine	0.2222
p.S1384Y	TCGA-NJ-A4YP	LUAD	TCGA	SKENT	DEG_APCC_KENBOX_2	1384:1388	Mutation altering degron motif	0.712
p.S1384Y	DO218943	LUAD	ICGC	SKENT	DEG_APCC_KENBOX_2	1384:1388	Mutation altering degron motif	0.712
p.K1819R	TCGA-UY-A78K	BLCA	TCGA	SKENT	DEG_APCC_KENBOX_2	1818:1822	Mutation altering degron motif	0.7237
p.K1819R	DO219031	BLCA	ICGC	SKENT	DEG_APCC_KENBOX_2	1818:1822	Mutation altering degron motif	0.7237
p.K1819R	DO231772	LINC	ICGC	SKENT	DEG_APCC_KENBOX_2	1818:1822	Mutation altering degron motif	0.7237
p.R1420Q	TCGA-VS-A94X	CESC	TCGA	VESTT	DEG_SPOP_SBC_1	1425:1429	Mutation rewiring degron network	0.1944
p.R1420Q	DO51632	CESC	ICGC	VESTT	DEG_SPOP_SBC_1	1425:1429	Mutation rewiring degron network	0.1944
p.D1433H	DO224905	BRCA	ICGC	DKENS	DEG_APCC_KENBOX_2	1433:1437	Mutation altering degron motif	0.6577
p.F1195S	DO223474	CLLE	ICGC	VVSSS	DEG_SPOP_SBC_1	1196:1200	Mutation rewiring degron network	0.3056
p.R1444G	DO50403	ESAD	ICGC	DKENS	DEG_APCC_KENBOX_2	1433:1437	Mutation rewiring degron network	0.1389
p.T1816I	DO233245	GACA	ICGC	SKENT	DEG_APCC_KENBOX_2	1818:1822	Mutation rewiring degron network	0.2778
p.K1385Q	DO233629	GACA	ICGC	SKENT	DEG_APCC_KENBOX_2	1384:1388	Mutation altering degron motif	0.6944
p.K1016E	DO228902	LICA	ICGC	KKENM	DEG_APCC_KENBOX_2	1016:1020	Mutation altering degron motif	0.591
p.V1813F	DO229028	LICA	ICGC	SKENT	DEG_APCC_KENBOX_2	1818:1822	Mutation rewiring degron network	0.1944
p.R1443L	DO229025	LICA	ICGC	DKENS	DEG_APCC_KENBOX_2	1433:1437	Mutation rewiring degron network	0.1667
p.E1900D	DO50827	LIRI	ICGC	PEETPKME	DEG_SCF_FBW7_2	1884:1891	Mutation rewiring degron network	0.0833
p.N1019S	DO229221	THCA	ICGC	KKENM	DEG_APCC_KENBOX_2	1016:1020	Mutation altering degron motif	0.7069
p.N1381K	SIDM02040	Esophageal Carcinoma	GDSC	SKENT	DEG_APCC_KENBOX_2	1384:1388	Mutation rewiring degron network	0.25
p.S1427P	SIDM02059	Colorectal Carcinoma	GDSC	VESTT	DEG_SPOP_SBC_1	1425:1429	Mutation altering degron motif	0.7863
p.L1892P	SIDM02026	Colorectal Carcinoma	GDSC	PEETPKME	DEG_SCF_FBW7_2	1884:1891	Mutation rewiring degron network	0.3056
p.K1445N	SIDM01963	Colorectal Carcinoma	GDSC	DKENS	DEG_APCC_KENBOX_2	1433:1437	Mutation substituting flanking lysine	0.2222
p.Q1874H	SIDM00373	Endometrial Carcinoma	GDSC	PEETPKME	DEG_SCF_FBW7_2	1884:1891	Mutation rewiring degron network	0.0556
p.Q1874H	ACH-000974	Endometrial/Uterine Cancer	CCLE	PEETPKME	DEG_SCF_FBW7_2	1884:1891	Mutation rewiring degron network	0.0556
p.E1430G	SIDM01090	Colorectal Carcinoma	GDSC	DKENS	DEG_APCC_KENBOX_2	1433:1437	Mutation rewiring degron network	0.25
p.E1430G	SIDM01090	Colorectal Carcinoma	GDSC	VESTT	DEG_SPOP_SBC_1	1425:1429	Mutation rewiring degron network	0.3056
p.E1430G	ACH-000943	Colon/Colorectal Cancer	CCLE	DKENS	DEG_APCC_KENBOX_2	1433:1437	Mutation rewiring degron network	0.25
p.E1430G	ACH-000943	Colon/Colorectal Cancer	CCLE	VESTT	DEG_SPOP_SBC_1	1425:1429	Mutation rewiring degron network	0.3056
p.E1430G	RKO	large intestine	COSMIC	DKENS	DEG_APCC_KENBOX_2	1433:1437	Mutation rewiring degron network	0.25
p.E1430G	RKO	large intestine	COSMIC	VESTT	DEG_SPOP_SBC_1	1425:1429	Mutation rewiring degron network	0.3056
p.T1428I	SIDM01199	Hepatocellular Carcinoma	GDSC	VESTT	DEG_SPOP_SBC_1	1425:1429	Mutation altering degron motif	0.8189
p.T1428I	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	VESTT	DEG_SPOP_SBC_1	1425:1429	Mutation altering degron motif	0.8189
p.T1428I	SIDM01559	Melanoma	GDSC	VESTT	DEG_SPOP_SBC_1	1425:1429	Mutation altering degron motif	0.8189
p.E1878K	SIDM00789	Colorectal Carcinoma	GDSC	PEETPKME	DEG_SCF_FBW7_2	1884:1891	Mutation rewiring degron network	0.1667
p.E1878K	ACH-000997	Colon/Colorectal Cancer	CCLE	PEETPKME	DEG_SCF_FBW7_2	1884:1891	Mutation rewiring degron network	0.1667
p.E1878K	ACH-001061	Colon/Colorectal Cancer	CCLE	PEETPKME	DEG_SCF_FBW7_2	1884:1891	Mutation rewiring degron network	0.1667
p.E1878K	ACH-001091	Colon/Colorectal Cancer	CCLE	PEETPKME	DEG_SCF_FBW7_2	1884:1891	Mutation rewiring degron network	0.1667
p.E1878K	HCT-15	large intestine	COSMIC	PEETPKME	DEG_SCF_FBW7_2	1884:1891	Mutation rewiring degron network	0.1667
p.S1394P	SIDM00589	Oral Cavity Carcinoma	GDSC	SKENT	DEG_APCC_KENBOX_2	1384:1388	Mutation blocking phosphorylation signal	0.6111
p.S1394P	SIDM01756	Chronic Myelogenous Leukemia	GDSC	SKENT	DEG_APCC_KENBOX_2	1384:1388	Mutation blocking phosphorylation signal	0.6111
p.S1394P	ACH-000076	Leukemia	CCLE	SKENT	DEG_APCC_KENBOX_2	1384:1388	Mutation blocking phosphorylation signal	0.6111
p.S1394P	ACH-000778	Head and Neck Cancer	CCLE	SKENT	DEG_APCC_KENBOX_2	1384:1388	Mutation blocking phosphorylation signal	0.6111
p.S1394P	HSC-3	upper aerodigestive tract	COSMIC	SKENT	DEG_APCC_KENBOX_2	1384:1388	Mutation blocking phosphorylation signal	0.6111
p.R1419W	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	VESTT	DEG_SPOP_SBC_1	1425:1429	Mutation rewiring degron network	0.1667
p.R1419W	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	VESTT	DEG_SPOP_SBC_1	1425:1429	Mutation rewiring degron network	0.1667
p.R1416Q	SIDM00500	Colorectal Carcinoma	GDSC	VESTT	DEG_SPOP_SBC_1	1425:1429	Mutation rewiring degron network	0.0833
p.R1416Q	ACH-000959	Colon/Colorectal Cancer	CCLE	VESTT	DEG_SPOP_SBC_1	1425:1429	Mutation rewiring degron network	0.0833
p.E1386D	SIDM01588	Endometrial Carcinoma	GDSC	SKENT	DEG_APCC_KENBOX_2	1384:1388	Mutation altering degron motif	0.6758
p.E1386D	ACH-000993	Endometrial/Uterine Cancer	CCLE	SKENT	DEG_APCC_KENBOX_2	1384:1388	Mutation altering degron motif	0.6758
p.S1189P	ACH-000937	Leukemia	CCLE	VVSSS	DEG_SPOP_SBC_1	1196:1200	Mutation blocking phosphorylation signal	0.5833
p.S1189P	PF-382	haematopoietic and lymphoid tissue	COSMIC	VVSSS	DEG_SPOP_SBC_1	1196:1200	Mutation blocking phosphorylation signal	0.5833
p.P1390T	ACH-000954	Endometrial/Uterine Cancer	CCLE	SKENT	DEG_APCC_KENBOX_2	1384:1388	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RIF1

UniProt ID: Q5UIP0

Entrez ID: 55183

Protein name: Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RIF1 in