DegronMD

Uniprot ID: Q5UIP0

Source protein: Telomere-associated protein RIF1

Source gene: RIF1

Class: DEG_APCC_KENBOX_2

Location: 1016:1020

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5931

ASA_SCORE: 123.5

COIL: 0.667

CONS_SCORE: 0.2761

DSS_SCORE: 0.5286

HELIX: 0.312

FCONS_SCORE: 0.7906

RIG_SCORE: 0.7056

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1026V	TCGA-38-4625	LUAD	TCGA	KKENM	DEG_APCC_KENBOX_2	0.1667
p.L1026V	DO23952	LUAD	ICGC	KKENM	DEG_APCC_KENBOX_2	0.1667
p.S1008L	TCGA-55-A48Y	LUAD	TCGA	KKENM	DEG_APCC_KENBOX_2	0.5556
p.S1008L	DO26160	LUAD	ICGC	KKENM	DEG_APCC_KENBOX_2	0.5556
p.M1020V	TCGA-EO-A22R	UCEC	TCGA	KKENM	DEG_APCC_KENBOX_2	0.6097
p.M1020V	DO42713	UCEC	ICGC	KKENM	DEG_APCC_KENBOX_2	0.6097
p.K1016E	DO228902	LICA	ICGC	KKENM	DEG_APCC_KENBOX_2	0.591
p.N1019S	DO229221	THCA	ICGC	KKENM	DEG_APCC_KENBOX_2	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5UIP0	Telomere-associated protein RIF1	DEG_APCC_KENBOX_2	1016:1020	KKENM	APC,CDC20,FZR1	0.5931	More...
Q9HAW4	Claspin	DEG_APCC_KENBOX_2	933:937	KKENM	APC,CDC20,FZR1	0.7544	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons