DegronMD

Uniprot ID: Q9HAW4

Source protein: Claspin

Source gene: CLSPN

Class: DEG_APCC_KENBOX_2

Location: 933:937

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7544

ASA_SCORE: 108.38

COIL: 0.4306

CONS_SCORE: 0.3585

DSS_SCORE: 0.5274

HELIX: 0.576

FCONS_SCORE: 1.052

RIG_SCORE: 0.7256

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H926Y	TCGA-AX-A06F	UCEC	TCGA	KKENM	DEG_APCC_KENBOX_2	0.1389
p.K933N	TCGA-E5-A4U1	BLCA	TCGA	KKENM	DEG_APCC_KENBOX_2	0.5806
p.K933N	DO44061	BLCA	ICGC	KKENM	DEG_APCC_KENBOX_2	0.5806
p.F937I	DO36495	READ	ICGC	KKENM	DEG_APCC_KENBOX_2	0.7415
p.T923I	DO219774	UCEC	ICGC	KKENM	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5UIP0	Telomere-associated protein RIF1	DEG_APCC_KENBOX_2	1016:1020	KKENM	APC,CDC20,FZR1	0.5931	More...
Q9HAW4	Claspin	DEG_APCC_KENBOX_2	933:937	KKENM	APC,CDC20,FZR1	0.7544	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons