DegronMD

Uniprot ID: Q5UIP0

Source protein: Telomere-associated protein RIF1

Source gene: RIF1

Class: DEG_SPOP_SBC_1

Location: 1196:1200

E3 ligase: SPOP

DEGRON score: 0.8866

ASA_SCORE: 91.06

COIL: 0.868

CONS_SCORE: 0.3578

DSS_SCORE: 0.395

HELIX: 0.0598

FCONS_SCORE: 1.1604

RIG_SCORE: 0.6968

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1200R	TCGA-19-5956	GBM	TCGA	VVSSS	DEG_SPOP_SBC_1	0.8538
p.S1200R	DO13863	GBM	ICGC	VVSSS	DEG_SPOP_SBC_1	0.8538
p.S1189F	TCGA-23-1116	OV	TCGA	VVSSS	DEG_SPOP_SBC_1	0.5833
p.S1189F	DO30050	OV	ICGC	VVSSS	DEG_SPOP_SBC_1	0.5833
p.S1194Y	TCGA-A4-7288	KIRP	TCGA	VVSSS	DEG_SPOP_SBC_1	0.7222
p.S1194Y	TCGA-DF-A2KU	UCEC	TCGA	VVSSS	DEG_SPOP_SBC_1	0.7222
p.S1194Y	DO20925	KIRP	ICGC	VVSSS	DEG_SPOP_SBC_1	0.7222
p.S1194Y	DO223286	UCEC	ICGC	VVSSS	DEG_SPOP_SBC_1	0.7222
p.V1196I	TCGA-A6-2686	COAD	TCGA	VVSSS	DEG_SPOP_SBC_1	0.7076
p.V1196I	DO7828	COAD	ICGC	VVSSS	DEG_SPOP_SBC_1	0.7076
p.N1193H	TCGA-AZ-4315	COAD	TCGA	VVSSS	DEG_SPOP_SBC_1	0.25
p.N1193H	DO8842	COAD	ICGC	VVSSS	DEG_SPOP_SBC_1	0.25
p.F1195S	DO223474	CLLE	ICGC	VVSSS	DEG_SPOP_SBC_1	0.3056
p.S1189P	ACH-000937	Leukemia	CCLE	VVSSS	DEG_SPOP_SBC_1	0.5833
p.S1189P	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	VVSSS	DEG_SPOP_SBC_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12035	Keratin, type II cytoskeletal 3	DEG_SPOP_SBC_1	525:529	VVSSS	SPOP	0.6552	More...
P41180	Extracellular calcium-sensing receptor	DEG_SPOP_SBC_1	1055:1059	VVSSS	SPOP	0.8121	More...
Q14525	Keratin, type I cuticular Ha3-II	DEG_SPOP_SBC_1	258:262	VVSSS	SPOP	0.5895	More...
Q5UIP0	Telomere-associated protein RIF1	DEG_SPOP_SBC_1	1196:1200	VVSSS	SPOP	0.8866	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	197:201	VVSSS	SPOP	0.913	More...
Q96JH7	Deubiquitinating protein VCPIP1	DEG_SPOP_SBC_1	1143:1147	VVSSS	SPOP	0.9956	More...
Q9H2K2	Poly [ADP-ribose] polymerase tankyrase-2	DEG_SPOP_SBC_1	854:858	VVSSS	SPOP	0.9829	More...
Q9P243	Zinc finger protein ZFAT	DEG_SPOP_SBC_1	581:585	VVSSS	SPOP	0.9599	More...
Q9P2N6	KAT8 regulatory NSL complex subunit 3	DEG_SPOP_SBC_1	715:719	VVSSS	SPOP	0.9927	More...
O60279	Sushi domain-containing protein 5	DEG_SPOP_SBC_1	362:366	VVSSS	SPOP	0.9462	More...
Q96K58	Zinc finger protein 668	DEG_SPOP_SBC_1	402:406	VVSSS	SPOP	0.9427	More...
Q9BQN1	Protein FAM83C	DEG_SPOP_SBC_1	376:380	VVSSS	SPOP	0.9887	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons