DegronMD

Uniprot ID: Q96JH7

Source protein: Deubiquitinating protein VCPIP1

Source gene: VCPIP1

Class: DEG_SPOP_SBC_1

Location: 1143:1147

E3 ligase: SPOP

DEGRON score: 0.9956

ASA_SCORE: 78.06

COIL: 0.6924

CONS_SCORE: 0.4014

DSS_SCORE: 0.6413

HELIX: 0.0596

FCONS_SCORE: 1.0506

RIG_SCORE: 0.6568

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1154P	TCGA-77-7142	LUSC	TCGA	VVSSS	DEG_SPOP_SBC_1	0.1389
p.Q1154P	DO26462	LUSC	ICGC	VVSSS	DEG_SPOP_SBC_1	0.1389
p.R1139S	TCGA-A1-A0SO	BRCA	TCGA	VVSSS	DEG_SPOP_SBC_1	0.2222
p.R1139S	DO2020	BRCA	ICGC	VVSSS	DEG_SPOP_SBC_1	0.2222
p.S1146F	TCGA-AP-A059	UCEC	TCGA	VVSSS	DEG_SPOP_SBC_1	0.7982
p.S1146F	DO41361	UCEC	ICGC	VVSSS	DEG_SPOP_SBC_1	0.7982
p.S1146Y	TCGA-AX-A0J0	UCEC	TCGA	VVSSS	DEG_SPOP_SBC_1	0.712
p.S1146Y	DO41133	UCEC	ICGC	VVSSS	DEG_SPOP_SBC_1	0.712
p.L1157V	TCGA-AZ-4315	COAD	TCGA	VVSSS	DEG_SPOP_SBC_1	0.0556
p.L1157V	DO8842	COAD	ICGC	VVSSS	DEG_SPOP_SBC_1	0.0556
p.G1151R	DO47128	RECA	ICGC	VVSSS	DEG_SPOP_SBC_1	0.2222
p.Q1154H	SIDM01106	Melanoma	GDSC	VVSSS	DEG_SPOP_SBC_1	0.1389
p.Q1154H	ACH-000822	Skin Cancer	CCLE	VVSSS	DEG_SPOP_SBC_1	0.1389
p.Q1154H	SK-MEL-24	skin	COSMIC	VVSSS	DEG_SPOP_SBC_1	0.1389
p.R1139K	SIDM00070	B-Cell Non-Hodgkin's Lymphoma	GDSC	VVSSS	DEG_SPOP_SBC_1	0.2222
p.R1139K	CRO-AP3	NS	COSMIC	VVSSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12035	Keratin, type II cytoskeletal 3	DEG_SPOP_SBC_1	525:529	VVSSS	SPOP	0.6552	More...
P41180	Extracellular calcium-sensing receptor	DEG_SPOP_SBC_1	1055:1059	VVSSS	SPOP	0.8121	More...
Q14525	Keratin, type I cuticular Ha3-II	DEG_SPOP_SBC_1	258:262	VVSSS	SPOP	0.5895	More...
Q5UIP0	Telomere-associated protein RIF1	DEG_SPOP_SBC_1	1196:1200	VVSSS	SPOP	0.8866	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	197:201	VVSSS	SPOP	0.913	More...
Q96JH7	Deubiquitinating protein VCPIP1	DEG_SPOP_SBC_1	1143:1147	VVSSS	SPOP	0.9956	More...
Q9H2K2	Poly [ADP-ribose] polymerase tankyrase-2	DEG_SPOP_SBC_1	854:858	VVSSS	SPOP	0.9829	More...
Q9P243	Zinc finger protein ZFAT	DEG_SPOP_SBC_1	581:585	VVSSS	SPOP	0.9599	More...
Q9P2N6	KAT8 regulatory NSL complex subunit 3	DEG_SPOP_SBC_1	715:719	VVSSS	SPOP	0.9927	More...
O60279	Sushi domain-containing protein 5	DEG_SPOP_SBC_1	362:366	VVSSS	SPOP	0.9462	More...
Q96K58	Zinc finger protein 668	DEG_SPOP_SBC_1	402:406	VVSSS	SPOP	0.9427	More...
Q9BQN1	Protein FAM83C	DEG_SPOP_SBC_1	376:380	VVSSS	SPOP	0.9887	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons