DegronMD - P41180(CASR)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V1066M	TCGA-05-5428	LUAD	TCGA	VVSSS	DEG_SPOP_SBC_1	1055:1059	Mutation rewiring degron network	0.1389
p.V1066M	SIDM00118	Colorectal Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	1055:1059	Mutation rewiring degron network	0.1389
p.V1066M	HCC2998	large intestine	COSMIC	VVSSS	DEG_SPOP_SBC_1	1055:1059	Mutation rewiring degron network	0.1389
p.A1063T	TCGA-A5-A0G2	UCEC	TCGA	VVSSS	DEG_SPOP_SBC_1	1055:1059	Mutation rewiring degron network	0.2222
p.R1051Q	TCGA-AB-2806	LAML	TCGA	VVSSS	DEG_SPOP_SBC_1	1055:1059	Mutation rewiring degron network	0.2222
p.P1045S	TCGA-E6-A1LX	UCEC	TCGA	VVSSS	DEG_SPOP_SBC_1	1055:1059	Mutation rewiring degron network	0.0556
p.P1045S	SIDM00207	Glioblastoma	GDSC	VVSSS	DEG_SPOP_SBC_1	1055:1059	Mutation rewiring degron network	0.0556
p.P1045S	D-542MG	central nervous system	COSMIC	VVSSS	DEG_SPOP_SBC_1	1055:1059	Mutation rewiring degron network	0.0556
p.P1045A	TCGA-F7-A624	HNSC	TCGA	VVSSS	DEG_SPOP_SBC_1	1055:1059	Mutation rewiring degron network	0.0556
p.E1053K	TCGA-IQ-A61H	HNSC	TCGA	VVSSS	DEG_SPOP_SBC_1	1055:1059	Mutation rewiring degron network	0.2778
p.G1066R	DO816	BLCA	ICGC	VVSSS	DEG_SPOP_SBC_1	1055:1059	Mutation rewiring degron network	0.1389
p.S1051P	DO222755	COCA	ICGC	VVSSS	DEG_SPOP_SBC_1	1055:1059	Mutation rewiring degron network	0.2222
p.V1055A	DO233917	GACA	ICGC	VVSSS	DEG_SPOP_SBC_1	1055:1059	Mutation altering degron motif	0.5825
p.G1068C	DO229037	LICA	ICGC	VVSSS	DEG_SPOP_SBC_1	1055:1059	Mutation rewiring degron network	0.0833
p.E1045K	DO50924	LICA	ICGC	VVSSS	DEG_SPOP_SBC_1	1055:1059	Mutation rewiring degron network	0.0556
p.S1061G	DO23078	LIHC	ICGC	VVSSS	DEG_SPOP_SBC_1	1055:1059	Mutation rewiring degron network	0.2778
p.S1061N	DO24100	LUAD	ICGC	VVSSS	DEG_SPOP_SBC_1	1055:1059	Mutation rewiring degron network	0.2778
p.V1056M	DO24005	LUAD	ICGC	VVSSS	DEG_SPOP_SBC_1	1055:1059	Mutation altering degron motif	0.6097
p.V1056M	ACH-001081	Colon/Colorectal Cancer	CCLE	VVSSS	DEG_SPOP_SBC_1	1055:1059	Mutation altering degron motif	0.6097
p.V1056M	HCC2998	large intestine	COSMIC	VVSSS	DEG_SPOP_SBC_1	1055:1059	Mutation altering degron motif	0.6097
p.S1065G	DO42023	UCEC	ICGC	VVSSS	DEG_SPOP_SBC_1	1055:1059	Mutation rewiring degron network	0.1667
p.A1053T	DO41235	UCEC	ICGC	VVSSS	DEG_SPOP_SBC_1	1055:1059	Mutation rewiring degron network	0.2778
p.P1057H	SIDM01387	Small Cell Lung Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	1055:1059	Mutation altering degron motif	0.7694
p.P1047H	ACH-000921	Lung Cancer	CCLE	VVSSS	DEG_SPOP_SBC_1	1055:1059	Mutation rewiring degron network	0.1111

Kaplan plot for CASR in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CASR

UniProt ID: P41180

Entrez ID: 846

Protein name: Extracellular calcium-sensing receptor (CaR) (CaSR) (hCasR) (Parathyroid cell calcium-sensing receptor 1) (PCaR1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CASR in