DegronMD

Uniprot ID: P41180

Source protein: Extracellular calcium-sensing receptor

Source gene: CASR

Class: DEG_SPOP_SBC_1

Location: 1055:1059

E3 ligase: SPOP

DEGRON score: 0.8121

ASA_SCORE: 71.44

COIL: 0.7066

CONS_SCORE: 0.259

DSS_SCORE: 0.4902

HELIX: 0.093

FCONS_SCORE: 0.967

RIG_SCORE: 0.7481

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1066M	TCGA-05-5428	LUAD	TCGA	VVSSS	DEG_SPOP_SBC_1	0.1389
p.V1066M	SIDM00118	Colorectal Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	0.1389
p.V1066M	HCC2998	large_intestine	COSMIC	VVSSS	DEG_SPOP_SBC_1	0.1389
p.A1063T	TCGA-A5-A0G2	UCEC	TCGA	VVSSS	DEG_SPOP_SBC_1	0.2222
p.R1051Q	TCGA-AB-2806	LAML	TCGA	VVSSS	DEG_SPOP_SBC_1	0.2222
p.P1045S	TCGA-E6-A1LX	UCEC	TCGA	VVSSS	DEG_SPOP_SBC_1	0.0556
p.P1045S	SIDM00207	Glioblastoma	GDSC	VVSSS	DEG_SPOP_SBC_1	0.0556
p.P1045S	D-542MG	central_nervous_system	COSMIC	VVSSS	DEG_SPOP_SBC_1	0.0556
p.P1045A	TCGA-F7-A624	HNSC	TCGA	VVSSS	DEG_SPOP_SBC_1	0.0556
p.E1053K	TCGA-IQ-A61H	HNSC	TCGA	VVSSS	DEG_SPOP_SBC_1	0.2778
p.G1066R	DO816	BLCA	ICGC	VVSSS	DEG_SPOP_SBC_1	0.1389
p.S1051P	DO222755	COCA	ICGC	VVSSS	DEG_SPOP_SBC_1	0.2222
p.V1055A	DO233917	GACA	ICGC	VVSSS	DEG_SPOP_SBC_1	0.5825
p.G1068C	DO229037	LICA	ICGC	VVSSS	DEG_SPOP_SBC_1	0.0833
p.E1045K	DO50924	LICA	ICGC	VVSSS	DEG_SPOP_SBC_1	0.0556
p.S1061G	DO23078	LIHC	ICGC	VVSSS	DEG_SPOP_SBC_1	0.2778
p.S1061N	DO24100	LUAD	ICGC	VVSSS	DEG_SPOP_SBC_1	0.2778
p.V1056M	DO24005	LUAD	ICGC	VVSSS	DEG_SPOP_SBC_1	0.6097
p.V1056M	ACH-001081	Colon/Colorectal Cancer	CCLE	VVSSS	DEG_SPOP_SBC_1	0.6097
p.V1056M	HCC2998	large_intestine	COSMIC	VVSSS	DEG_SPOP_SBC_1	0.6097
p.S1065G	DO42023	UCEC	ICGC	VVSSS	DEG_SPOP_SBC_1	0.1667
p.A1053T	DO41235	UCEC	ICGC	VVSSS	DEG_SPOP_SBC_1	0.2778
p.P1057H	SIDM01387	Small Cell Lung Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	0.7694
p.P1047H	ACH-000921	Lung Cancer	CCLE	VVSSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12035	Keratin, type II cytoskeletal 3	DEG_SPOP_SBC_1	525:529	VVSSS	SPOP	0.6552	More...
P41180	Extracellular calcium-sensing receptor	DEG_SPOP_SBC_1	1055:1059	VVSSS	SPOP	0.8121	More...
Q14525	Keratin, type I cuticular Ha3-II	DEG_SPOP_SBC_1	258:262	VVSSS	SPOP	0.5895	More...
Q5UIP0	Telomere-associated protein RIF1	DEG_SPOP_SBC_1	1196:1200	VVSSS	SPOP	0.8866	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	197:201	VVSSS	SPOP	0.913	More...
Q96JH7	Deubiquitinating protein VCPIP1	DEG_SPOP_SBC_1	1143:1147	VVSSS	SPOP	0.9956	More...
Q9H2K2	Poly [ADP-ribose] polymerase tankyrase-2	DEG_SPOP_SBC_1	854:858	VVSSS	SPOP	0.9829	More...
Q9P243	Zinc finger protein ZFAT	DEG_SPOP_SBC_1	581:585	VVSSS	SPOP	0.9599	More...
Q9P2N6	KAT8 regulatory NSL complex subunit 3	DEG_SPOP_SBC_1	715:719	VVSSS	SPOP	0.9927	More...
O60279	Sushi domain-containing protein 5	DEG_SPOP_SBC_1	362:366	VVSSS	SPOP	0.9462	More...
Q96K58	Zinc finger protein 668	DEG_SPOP_SBC_1	402:406	VVSSS	SPOP	0.9427	More...
Q9BQN1	Protein FAM83C	DEG_SPOP_SBC_1	376:380	VVSSS	SPOP	0.9887	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons