DegronMD - Q96JH7(VCPIP1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q1154P	TCGA-77-7142	LUSC	TCGA	VVSSS	DEG_SPOP_SBC_1	1143:1147	Mutation rewiring degron network	0.1389
p.Q1154P	DO26462	LUSC	ICGC	VVSSS	DEG_SPOP_SBC_1	1143:1147	Mutation rewiring degron network	0.1389
p.R1139S	TCGA-A1-A0SO	BRCA	TCGA	VVSSS	DEG_SPOP_SBC_1	1143:1147	Mutation rewiring degron network	0.2222
p.R1139S	DO2020	BRCA	ICGC	VVSSS	DEG_SPOP_SBC_1	1143:1147	Mutation rewiring degron network	0.2222
p.S1146F	TCGA-AP-A059	UCEC	TCGA	VVSSS	DEG_SPOP_SBC_1	1143:1147	Mutation altering degron motif	0.7982
p.S1146F	DO41361	UCEC	ICGC	VVSSS	DEG_SPOP_SBC_1	1143:1147	Mutation altering degron motif	0.7982
p.S1146Y	TCGA-AX-A0J0	UCEC	TCGA	VVSSS	DEG_SPOP_SBC_1	1143:1147	Mutation altering degron motif	0.712
p.S1146Y	DO41133	UCEC	ICGC	VVSSS	DEG_SPOP_SBC_1	1143:1147	Mutation altering degron motif	0.712
p.L1157V	TCGA-AZ-4315	COAD	TCGA	VVSSS	DEG_SPOP_SBC_1	1143:1147	Mutation rewiring degron network	0.0556
p.L1157V	DO8842	COAD	ICGC	VVSSS	DEG_SPOP_SBC_1	1143:1147	Mutation rewiring degron network	0.0556
p.G1151R	DO47128	RECA	ICGC	VVSSS	DEG_SPOP_SBC_1	1143:1147	Mutation rewiring degron network	0.2222
p.Q1154H	SIDM01106	Melanoma	GDSC	VVSSS	DEG_SPOP_SBC_1	1143:1147	Mutation rewiring degron network	0.1389
p.Q1154H	ACH-000822	Skin Cancer	CCLE	VVSSS	DEG_SPOP_SBC_1	1143:1147	Mutation rewiring degron network	0.1389
p.Q1154H	SK-MEL-24	skin	COSMIC	VVSSS	DEG_SPOP_SBC_1	1143:1147	Mutation rewiring degron network	0.1389
p.R1139K	SIDM00070	B-Cell Non-Hodgkin's Lymphoma	GDSC	VVSSS	DEG_SPOP_SBC_1	1143:1147	Mutation rewiring degron network	0.2222
p.R1139K	CRO-AP3	NS	COSMIC	VVSSS	DEG_SPOP_SBC_1	1143:1147	Mutation rewiring degron network	0.2222

Kaplan plot for VCPIP1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VCPIP1

UniProt ID: Q96JH7

Entrez ID: 80124

Protein name: Deubiquitinating protein VCPIP1 (EC 3.4.19.12) (Valosin-containing protein p97/p47 complex-interacting protein 1) (Valosin-containing protein p97/p47 complex-interacting protein p135) (VCP/p47 complex-interacting 135-kDa protein)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for VCPIP1 in