DegronMD

Uniprot ID: P12035

Source protein: Keratin, type II cytoskeletal 3

Source gene: KRT3

Class: DEG_SPOP_SBC_1

Location: 525:529

E3 ligase: SPOP

DEGRON score: 0.6552

ASA_SCORE: 62.76

COIL: 0.5132

CONS_SCORE: 0.7388

DSS_SCORE: 0.3326

HELIX: 0.0108

FCONS_SCORE: 0.9916

RIG_SCORE: 0.7378

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T531N	TCGA-19-4068	GBM	TCGA	VVSSS	DEG_SPOP_SBC_1	0.2778
p.T531N	DO12028	GBM	ICGC	VVSSS	DEG_SPOP_SBC_1	0.2778
p.A520V	TCGA-A8-A09A	BRCA	TCGA	VVSSS	DEG_SPOP_SBC_1	0.1944
p.A520V	TCGA-BR-8372	STAD	TCGA	VVSSS	DEG_SPOP_SBC_1	0.1944
p.A520V	DO2955	BRCA	ICGC	VVSSS	DEG_SPOP_SBC_1	0.1944
p.A520V	DO47873	STAD	ICGC	VVSSS	DEG_SPOP_SBC_1	0.1944
p.Y538C	TCGA-J2-8194	LUAD	TCGA	VVSSS	DEG_SPOP_SBC_1	0.0833
p.Y538C	DO23971	LUAD	ICGC	VVSSS	DEG_SPOP_SBC_1	0.0833
p.V525A	DO45299	LIRI	ICGC	VVSSS	DEG_SPOP_SBC_1	0.5825
p.G539R	DO222384	MELA	ICGC	VVSSS	DEG_SPOP_SBC_1	0.0556
p.P518L	ACH-000123	Ovarian Cancer	CCLE	VVSSS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12035	Keratin, type II cytoskeletal 3	DEG_SPOP_SBC_1	525:529	VVSSS	SPOP	0.6552	More...
P41180	Extracellular calcium-sensing receptor	DEG_SPOP_SBC_1	1055:1059	VVSSS	SPOP	0.8121	More...
Q14525	Keratin, type I cuticular Ha3-II	DEG_SPOP_SBC_1	258:262	VVSSS	SPOP	0.5895	More...
Q5UIP0	Telomere-associated protein RIF1	DEG_SPOP_SBC_1	1196:1200	VVSSS	SPOP	0.8866	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	197:201	VVSSS	SPOP	0.913	More...
Q96JH7	Deubiquitinating protein VCPIP1	DEG_SPOP_SBC_1	1143:1147	VVSSS	SPOP	0.9956	More...
Q9H2K2	Poly [ADP-ribose] polymerase tankyrase-2	DEG_SPOP_SBC_1	854:858	VVSSS	SPOP	0.9829	More...
Q9P243	Zinc finger protein ZFAT	DEG_SPOP_SBC_1	581:585	VVSSS	SPOP	0.9599	More...
Q9P2N6	KAT8 regulatory NSL complex subunit 3	DEG_SPOP_SBC_1	715:719	VVSSS	SPOP	0.9927	More...
O60279	Sushi domain-containing protein 5	DEG_SPOP_SBC_1	362:366	VVSSS	SPOP	0.9462	More...
Q96K58	Zinc finger protein 668	DEG_SPOP_SBC_1	402:406	VVSSS	SPOP	0.9427	More...
Q9BQN1	Protein FAM83C	DEG_SPOP_SBC_1	376:380	VVSSS	SPOP	0.9887	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons