DegronMD

Uniprot ID: Q9H2K2

Source protein: Poly [ADP-ribose] polymerase tankyrase-2

Source gene: TNKS2

Class: DEG_SPOP_SBC_1

Location: 854:858

E3 ligase: SPOP

DEGRON score: 0.9829

ASA_SCORE: 62.82

COIL: 0.8602

CONS_SCORE: 0.2865

DSS_SCORE: 0.3898

HELIX: 0.0498

FCONS_SCORE: 0.8396

RIG_SCORE: 0.6359

Degron related mutations and impact score

Drug responses associated with TNKS2 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.N622fs*29 (No)	GDSC	XAV939	9.6637
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.N622fs*29 (No)	GDSC	XAV939	178.93
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.N622fs*29 (No)	GDSC	MN-64	80.65
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.N622fs*29 (No)	GDSC	WIKI4	37.501
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.N622fs*29 (No)	GDSC	AZ6102	8.3235
SIDM00951	LAML\|acute_myeloid_leukaemia	p.S791N (No)	GDSC	XAV939	18.4896
SIDM00951	LAML\|acute_myeloid_leukaemia	p.S791N (No)	GDSC	XAV939	17.421
SIDM00951	LAML\|acute_myeloid_leukaemia	p.S791N (No)	GDSC	MN-64	57.571
SIDM00951	LAML\|acute_myeloid_leukaemia	p.S791N (No)	GDSC	WIKI4	34.73
SIDM00951	LAML\|acute_myeloid_leukaemia	p.S791N (No)	GDSC	AZ6102	4.4365
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.T975A (No)	GDSC	XAV939	26.9132
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.T975A (No)	GDSC	XAV939	40.333
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.T975A (No)	GDSC	MN-64	55.658
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.T975A (No)	GDSC	WIKI4	21.896
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.T975A (No)	GDSC	AZ6102	5.0615
SIDM00997	THCA\|thyroid	p.P872L (No)	GDSC	XAV939	92.1397
SIDM00997	THCA\|thyroid	p.P872L (No)	GDSC	XAV939	118.18
SIDM00997	THCA\|thyroid	p.P872L (No)	GDSC	MN-64	90.891
SIDM00997	THCA\|thyroid	p.P872L (No)	GDSC	WIKI4	197.69
SIDM00997	THCA\|thyroid	p.P872L (No)	GDSC	AZ6102	84.801
SIDM00901	UCEC\|endometrium	p.A600T (No)	GDSC	XAV939	48.8033
SIDM00901	UCEC\|endometrium	p.A600T (No)	GDSC	XAV939	24.748
SIDM00901	UCEC\|endometrium	p.A600T (No)	GDSC	MN-64	63.574
SIDM00901	UCEC\|endometrium	p.A600T (No)	GDSC	WIKI4	120.69
SIDM00901	UCEC\|endometrium	p.A600T (No)	GDSC	AZ6102	9.0163
SIDM00654	SCLC\|lung_small_cell_carcinoma	p.N622fs*29 (No)	GDSC	XAV939	28.2535
SIDM00654	SCLC\|lung_small_cell_carcinoma	p.N622fs*29 (No)	GDSC	XAV939	63.953
SIDM00654	SCLC\|lung_small_cell_carcinoma	p.N622fs*29 (No)	GDSC	MN-64	40.711
SIDM00654	SCLC\|lung_small_cell_carcinoma	p.N622fs*29 (No)	GDSC	WIKI4	22.741
SIDM00654	SCLC\|lung_small_cell_carcinoma	p.N622fs*29 (No)	GDSC	AZ6102	7.0235
SIDM00980	STAD\|stomach	p.A424V (No)	GDSC	XAV939	26.8047
SIDM00980	STAD\|stomach	p.A424V (No)	GDSC	XAV939	65.54
SIDM00980	STAD\|stomach	p.A424V (No)	GDSC	MN-64	166.58
SIDM00980	STAD\|stomach	p.A424V (No)	GDSC	WIKI4	46.604
SIDM00980	STAD\|stomach	p.A424V (No)	GDSC	AZ6102	7.6066
SIDM00251	STAD\|stomach	p.P872L (No)	GDSC	XAV939	27.0292
SIDM00251	STAD\|stomach	p.P872L (No)	GDSC	XAV939	54.848
SIDM00251	STAD\|stomach	p.P872L (No)	GDSC	WIKI4	152.45
SIDM00251	STAD\|stomach	p.P872L (No)	GDSC	AZ6102	15.364
SIDM00214	COREAD\|large_intestine	p.A1024T (No)	GDSC	XAV939	5.2684
SIDM00214	COREAD\|large_intestine	p.A1024T (No)	GDSC	XAV939	51.872
SIDM00214	COREAD\|large_intestine	p.A1024T (No)	GDSC	MN-64	45.072
SIDM00214	COREAD\|large_intestine	p.A1024T (No)	GDSC	WIKI4	12.582
SIDM00214	COREAD\|large_intestine	p.A1024T (No)	GDSC	AZ6102	27.925
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.T345S (No)	GDSC	XAV939	13.7175
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.T345S (No)	GDSC	XAV939	32.643
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.T345S (No)	GDSC	MN-64	31.387
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.T345S (No)	GDSC	WIKI4	37.338
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.T345S (No)	GDSC	AZ6102	3.084
SIDM00377	UNCLASSIFIED\|uterus	p.P771R (No)	GDSC	XAV939	7.004
SIDM00377	UNCLASSIFIED\|uterus	p.P771R (No)	GDSC	XAV939	36.861
SIDM00377	UNCLASSIFIED\|uterus	p.P771R (No)	GDSC	MN-64	255.5
SIDM00377	UNCLASSIFIED\|uterus	p.P771R (No)	GDSC	WIKI4	54.363
SIDM00377	UNCLASSIFIED\|uterus	p.P771R (No)	GDSC	AZ6102	22.165
SIDM00516	SKCM\|melanoma	p.T173I (No)	GDSC	XAV939	64.2137
SIDM00516	SKCM\|melanoma	p.M1115I (No)	GDSC	XAV939	64.2137
SIDM00151	OV\|ovary	p.N622fs*29 (No)	GDSC	XAV939	23.2978
SIDM00151	OV\|ovary	p.N622fs*29 (No)	GDSC	XAV939	15.182
SIDM00151	OV\|ovary	p.N622fs*29 (No)	GDSC	MN-64	29.879
SIDM00151	OV\|ovary	p.N622fs*29 (No)	GDSC	WIKI4	9.4223
SIDM00151	OV\|ovary	p.N622fs*29 (No)	GDSC	AZ6102	1.6334
SIDM00756	LUAD\|lung_NSCLC_adenocarcinoma	p.P318A (No)	GDSC	XAV939	36.981
SIDM00756	LUAD\|lung_NSCLC_adenocarcinoma	p.P318A (No)	GDSC	WIKI4	32.286
SIDM00756	LUAD\|lung_NSCLC_adenocarcinoma	p.P318A (No)	GDSC	AZ6102	6.6804
SIDM01259	ALL\|lymphoblastic_leukemia	p.N622fs*29 (No)	GDSC	XAV939	37.7188
SIDM01259	ALL\|lymphoblastic_leukemia	p.N622fs*29 (No)	GDSC	XAV939	155.45
SIDM01259	ALL\|lymphoblastic_leukemia	p.N622fs*29 (No)	GDSC	MN-64	271.36
SIDM01259	ALL\|lymphoblastic_leukemia	p.N622fs*29 (No)	GDSC	WIKI4	38.514
SIDM01259	ALL\|lymphoblastic_leukemia	p.N622fs*29 (No)	GDSC	AZ6102	14.481
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.L464I (No)	GDSC	XAV939	12.4693
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.L464I (No)	GDSC	XAV939	27.681
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.L464I (No)	GDSC	MN-64	100.94
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.L464I (No)	GDSC	WIKI4	20.746
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.L464I (No)	GDSC	AZ6102	5.5644
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.L958M (No)	GDSC	XAV939	12.4693
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.L958M (No)	GDSC	XAV939	27.681
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.L958M (No)	GDSC	MN-64	100.94
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.L958M (No)	GDSC	WIKI4	20.746
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.L958M (No)	GDSC	AZ6102	5.5644
SIDM00112	KIRC\|kidney	p.H701R (No)	GDSC	XAV939	14.4773
SIDM01148	MM\|myeloma	p.E964K (No)	GDSC	XAV939	19.4154
SIDM01148	MM\|myeloma	p.E964K (No)	GDSC	XAV939	49.734
SIDM01148	MM\|myeloma	p.E964K (No)	GDSC	MN-64	88.096
SIDM01148	MM\|myeloma	p.E964K (No)	GDSC	WIKI4	54.654
SIDM01148	MM\|myeloma	p.E964K (No)	GDSC	AZ6102	7.498
SIDM00783	COREAD\|large_intestine	p.G1144delG (No)	GDSC	XAV939	38.9965
SIDM00783	COREAD\|large_intestine	p.G1144delG (No)	GDSC	XAV939	93.678
SIDM00783	COREAD\|large_intestine	p.G1144delG (No)	GDSC	MN-64	81.255
SIDM00783	COREAD\|large_intestine	p.G1144delG (No)	GDSC	WIKI4	44.17
SIDM00783	COREAD\|large_intestine	p.G1144delG (No)	GDSC	AZ6102	9.9173
SIDM00217	COREAD\|large_intestine	p.E1015K (No)	GDSC	XAV939	56.0028
SIDM00217	COREAD\|large_intestine	p.E1015K (No)	GDSC	XAV939	87.794
SIDM00217	COREAD\|large_intestine	p.E1015K (No)	GDSC	MN-64	234.76
SIDM01141	OV\|ovary	p.N118S (No)	GDSC	XAV939	26.7544
SIDM01141	OV\|ovary	p.N118S (No)	GDSC	XAV939	154.19
SIDM01141	OV\|ovary	p.N118S (No)	GDSC	MN-64	75.702
SIDM01141	OV\|ovary	p.N118S (No)	GDSC	WIKI4	242.9
SIDM01141	OV\|ovary	p.N118S (No)	GDSC	AZ6102	151.22
SIDM00216	COREAD\|large_intestine	p.S665F (No)	GDSC	XAV939	157.83
SIDM00216	COREAD\|large_intestine	p.S665F (No)	GDSC	MN-64	128.98
SIDM00216	COREAD\|large_intestine	p.S665F (No)	GDSC	WIKI4	35.987
SIDM00216	COREAD\|large_intestine	p.S665F (No)	GDSC	AZ6102	4.7673
SIDM00363	LAML\|acute_myeloid_leukaemia	p.S1033F (No)	GDSC	XAV939	22.4365
SIDM00363	LAML\|acute_myeloid_leukaemia	p.S1033F (No)	GDSC	WIKI4	80.888
SIDM00363	LAML\|acute_myeloid_leukaemia	p.S1033F (No)	GDSC	AZ6102	107.89
SIDM00660	COREAD\|large_intestine	p.N622fs*29 (No)	GDSC	XAV939	40.0201
SIDM00660	COREAD\|large_intestine	p.N622fs*29 (No)	GDSC	XAV939	167.43
SIDM00660	COREAD\|large_intestine	p.N622fs*29 (No)	GDSC	MN-64	140.28
SIDM00660	COREAD\|large_intestine	p.N622fs*29 (No)	GDSC	WIKI4	89.924
SIDM00660	COREAD\|large_intestine	p.N622fs*29 (No)	GDSC	AZ6102	9.804
SIDM01067	LUAD\|lung_NSCLC_adenocarcinoma	p.V542M (No)	GDSC	XAV939	73.1798
SIDM01067	LUAD\|lung_NSCLC_adenocarcinoma	p.V542M (No)	GDSC	XAV939	23.498
SIDM01067	LUAD\|lung_NSCLC_adenocarcinoma	p.V542M (No)	GDSC	MN-64	343.92
SIDM01067	LUAD\|lung_NSCLC_adenocarcinoma	p.V542M (No)	GDSC	WIKI4	61.465
SIDM01067	LUAD\|lung_NSCLC_adenocarcinoma	p.V542M (No)	GDSC	AZ6102	15.353
SIDM00905	CESC\|cervix	p.E506K (No)	GDSC	XAV939	117.31
SIDM00905	CESC\|cervix	p.E506K (No)	GDSC	MN-64	225.8
SIDM00905	CESC\|cervix	p.E506K (No)	GDSC	WIKI4	32.62
SIDM00905	CESC\|cervix	p.E506K (No)	GDSC	AZ6102	3.7234
SIDM00819	KIRC\|kidney	p.L452F (No)	GDSC	XAV939	4.1497
SIDM01146	STAD\|stomach	p.N622fs*29 (No)	GDSC	XAV939	55.8787
SIDM01146	STAD\|stomach	p.N622fs*29 (No)	GDSC	XAV939	56.975
SIDM01146	STAD\|stomach	p.N622fs*29 (No)	GDSC	MN-64	83.654
SIDM01146	STAD\|stomach	p.N622fs*29 (No)	GDSC	WIKI4	35.573
SIDM01146	STAD\|stomach	p.N622fs*29 (No)	GDSC	AZ6102	13.593
SIDM00282	COREAD\|large_intestine	p.N622fs*29 (No)	GDSC	XAV939	127.0465
SIDM00282	COREAD\|large_intestine	p.N622fs*29 (No)	GDSC	XAV939	72.076
SIDM00282	COREAD\|large_intestine	p.N622fs*29 (No)	GDSC	MN-64	234.68
SIDM00282	COREAD\|large_intestine	p.N622fs*29 (No)	GDSC	WIKI4	65.973
SIDM00282	COREAD\|large_intestine	p.N622fs*29 (No)	GDSC	AZ6102	81.504
SIDM00217	COREAD\|large_intestine	p.N622fs*29 (No)	GDSC	XAV939	56.0028
SIDM00217	COREAD\|large_intestine	p.N622fs*29 (No)	GDSC	XAV939	87.794
SIDM00217	COREAD\|large_intestine	p.N622fs*29 (No)	GDSC	MN-64	234.76
SIDM01112	UNCLASSIFIED\|bone_other	p.N307S (No)	GDSC	XAV939	65.8687
SIDM01112	UNCLASSIFIED\|bone_other	p.N307S (No)	GDSC	WIKI4	61.334
SIDM01112	UNCLASSIFIED\|bone_other	p.N307S (No)	GDSC	AZ6102	9.2579
SIDM01044	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.F358L (No)	GDSC	XAV939	14.0943
SIDM01044	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.F358L (No)	GDSC	XAV939	253.49
SIDM01044	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.F358L (No)	GDSC	MN-64	158.81
SIDM01044	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.F358L (No)	GDSC	WIKI4	41.994
SIDM01044	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.F358L (No)	GDSC	AZ6102	14.332
SIDM00254	NB\|neuroblastoma	p.G936R (No)	GDSC	XAV939	43.128
SIDM00980	STAD\|stomach	p.N622fs*29 (No)	GDSC	XAV939	26.8047
SIDM00980	STAD\|stomach	p.N622fs*29 (No)	GDSC	XAV939	65.54
SIDM00980	STAD\|stomach	p.N622fs*29 (No)	GDSC	MN-64	166.58
SIDM00980	STAD\|stomach	p.N622fs*29 (No)	GDSC	WIKI4	46.604
SIDM00980	STAD\|stomach	p.N622fs*29 (No)	GDSC	AZ6102	7.6066
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.I1051T (No)	GDSC	XAV939	44.3323
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.I1051T (No)	GDSC	XAV939	33.569
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.I1051T (No)	GDSC	MN-64	131.89
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.I1051T (No)	GDSC	WIKI4	31.513
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.I1051T (No)	GDSC	AZ6102	7.9393
SIDM00373	UCEC\|endometrium	p.T1079I (No)	GDSC	XAV939	2.3655
SIDM00373	UCEC\|endometrium	p.T1079I (No)	GDSC	XAV939	32.553
SIDM00373	UCEC\|endometrium	p.T1079I (No)	GDSC	MN-64	82.765
SIDM00373	UCEC\|endometrium	p.T1079I (No)	GDSC	WIKI4	38.808
SIDM00373	UCEC\|endometrium	p.T1079I (No)	GDSC	AZ6102	3.3947
SIDM00806	UNCLASSIFIED\|osteosarcoma	p.L730V (No)	GDSC	XAV939	29.6085
SIDM00806	UNCLASSIFIED\|osteosarcoma	p.L730V (No)	GDSC	XAV939	119.16
SIDM00806	UNCLASSIFIED\|osteosarcoma	p.L730V (No)	GDSC	MN-64	47.802
SIDM00806	UNCLASSIFIED\|osteosarcoma	p.L730V (No)	GDSC	WIKI4	26.834
SIDM00806	UNCLASSIFIED\|osteosarcoma	p.L730V (No)	GDSC	AZ6102	8.0158
SIDM01178	UNCLASSIFIED\|urogenital_system_other	p.N118K (No)	GDSC	XAV939	8.6008
SIDM00238	OV\|ovary	p.A753V (No)	GDSC	XAV939	23.8619
SIDM00238	OV\|ovary	p.A753V (No)	GDSC	XAV939	182.81
SIDM00238	OV\|ovary	p.A753V (No)	GDSC	MN-64	188.14
SIDM00968	OV\|ovary	p.K1014I (No)	GDSC	XAV939	5.8272
SIDM00968	OV\|ovary	p.K1014I (No)	GDSC	XAV939	386.85
SIDM00968	OV\|ovary	p.K1014I (No)	GDSC	MN-64	77.483
SIDM00968	OV\|ovary	p.K1014I (No)	GDSC	WIKI4	33.629
SIDM00968	OV\|ovary	p.K1014I (No)	GDSC	AZ6102	18.841
SIDM00193	COREAD\|large_intestine	p.F965C (No)	GDSC	XAV939	110.2345
SIDM00193	COREAD\|large_intestine	p.F965C (No)	GDSC	XAV939	122.62
SIDM00193	COREAD\|large_intestine	p.F965C (No)	GDSC	MN-64	124.55

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12035	Keratin, type II cytoskeletal 3	DEG_SPOP_SBC_1	525:529	VVSSS	SPOP	0.6552	More...
P41180	Extracellular calcium-sensing receptor	DEG_SPOP_SBC_1	1055:1059	VVSSS	SPOP	0.8121	More...
Q14525	Keratin, type I cuticular Ha3-II	DEG_SPOP_SBC_1	258:262	VVSSS	SPOP	0.5895	More...
Q5UIP0	Telomere-associated protein RIF1	DEG_SPOP_SBC_1	1196:1200	VVSSS	SPOP	0.8866	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	197:201	VVSSS	SPOP	0.913	More...
Q96JH7	Deubiquitinating protein VCPIP1	DEG_SPOP_SBC_1	1143:1147	VVSSS	SPOP	0.9956	More...
Q9H2K2	Poly [ADP-ribose] polymerase tankyrase-2	DEG_SPOP_SBC_1	854:858	VVSSS	SPOP	0.9829	More...
Q9P243	Zinc finger protein ZFAT	DEG_SPOP_SBC_1	581:585	VVSSS	SPOP	0.9599	More...
Q9P2N6	KAT8 regulatory NSL complex subunit 3	DEG_SPOP_SBC_1	715:719	VVSSS	SPOP	0.9927	More...
O60279	Sushi domain-containing protein 5	DEG_SPOP_SBC_1	362:366	VVSSS	SPOP	0.9462	More...
Q96K58	Zinc finger protein 668	DEG_SPOP_SBC_1	402:406	VVSSS	SPOP	0.9427	More...
Q9BQN1	Protein FAM83C	DEG_SPOP_SBC_1	376:380	VVSSS	SPOP	0.9887	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VVSSS

Degron related mutations and impact score

Drug responses associated with TNKS2 mutations

All proteins holding degron of VVSSS