DegronMD - Q9P2N6(KANSL3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I780V	TCGA-AA-A01R	COAD	TCGA	LPTPMQS	DEG_SCF_FBW7_1	785:791	Mutation rewiring degron network	0.1944
p.I780V	DO7934	COAD	ICGC	LPTPMQS	DEG_SCF_FBW7_1	785:791	Mutation rewiring degron network	0.1944
p.E590K	TCGA-AJ-A2QM	UCEC	TCGA	PGTSS	DEG_SPOP_SBC_1	599:603	Mutation rewiring degron network	0.0833
p.E590K	DO43690	UCEC	ICGC	PGTSS	DEG_SPOP_SBC_1	599:603	Mutation rewiring degron network	0.0833
p.S691P	TCGA-AP-A1DR	UCEC	TCGA	AKSSS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.1389
p.S691P	DO43747	UCEC	ICGC	AKSSS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.1389
p.A791V	TCGA-BR-4361	STAD	TCGA	LPTPMQS	DEG_SCF_FBW7_1	785:791	Mutation altering degron motif	0.6936
p.A791V	DO38887	STAD	ICGC	LPTPMQS	DEG_SCF_FBW7_1	785:791	Mutation altering degron motif	0.6936
p.A708D	TCGA-D3-A2J8	SKCM	TCGA	AKSSS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.1667
p.A708D	TCGA-D3-A2J8	SKCM	TCGA	VVSSS	DEG_SPOP_SBC_1	715:719	Mutation rewiring degron network	0.1389
p.A708D	DO37778	SKCM	ICGC	AKSSS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.1667
p.A708D	DO37778	SKCM	ICGC	VVSSS	DEG_SPOP_SBC_1	715:719	Mutation rewiring degron network	0.1389
p.G795W	TCGA-D3-A2JO	SKCM	TCGA	LPTPMQS	DEG_SCF_FBW7_1	785:791	Mutation rewiring degron network	0.2222
p.G795W	DO47619	SKCM	ICGC	LPTPMQS	DEG_SCF_FBW7_1	785:791	Mutation rewiring degron network	0.2222
p.P605L	TCGA-D3-A8GQ	SKCM	TCGA	PGTSS	DEG_SPOP_SBC_1	599:603	Mutation rewiring degron network	0.2778
p.P605L	DO51246	SKCM	ICGC	PGTSS	DEG_SPOP_SBC_1	599:603	Mutation rewiring degron network	0.2778
p.Q726E	TCGA-D8-A27L	BRCA	TCGA	VVSSS	DEG_SPOP_SBC_1	715:719	Mutation rewiring degron network	0.1389
p.Q726E	DO2180	BRCA	ICGC	VVSSS	DEG_SPOP_SBC_1	715:719	Mutation rewiring degron network	0.1389
p.G794D	TCGA-DU-5851	LGG	TCGA	LPTPMQS	DEG_SCF_FBW7_1	785:791	Mutation rewiring degron network	0.25
p.G794D	DO22768	LGG	ICGC	LPTPMQS	DEG_SCF_FBW7_1	785:791	Mutation rewiring degron network	0.25
p.P793L	TCGA-DX-AB2E	SARC	TCGA	LPTPMQS	DEG_SCF_FBW7_1	785:791	Mutation rewiring degron network	0.2778
p.P793L	DO220073	SARC	ICGC	LPTPMQS	DEG_SCF_FBW7_1	785:791	Mutation rewiring degron network	0.2778
p.R778C	TCGA-EE-A2GO	SKCM	TCGA	LPTPMQS	DEG_SCF_FBW7_1	785:791	Mutation rewiring degron network	0.1389
p.R778C	DO37823	SKCM	ICGC	LPTPMQS	DEG_SCF_FBW7_1	785:791	Mutation rewiring degron network	0.1389
p.L596I	TCGA-FP-7735	STAD	TCGA	PGTSS	DEG_SPOP_SBC_1	599:603	Mutation rewiring degron network	0.25
p.L596I	DO38199	STAD	ICGC	PGTSS	DEG_SPOP_SBC_1	599:603	Mutation rewiring degron network	0.25
p.P711S	TCGA-FW-A3TU	SKCM	TCGA	AKSSS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.0833
p.P711S	TCGA-FW-A3TU	SKCM	TCGA	VVSSS	DEG_SPOP_SBC_1	715:719	Mutation rewiring degron network	0.2222
p.P711S	DO37441	SKCM	ICGC	AKSSS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.0833
p.P711S	DO37441	SKCM	ICGC	VVSSS	DEG_SPOP_SBC_1	715:719	Mutation rewiring degron network	0.2222
p.G794R	TCGA-KQ-A41S	BLCA	TCGA	LPTPMQS	DEG_SCF_FBW7_1	785:791	Mutation rewiring degron network	0.25
p.G794R	DO223593	BLCA	ICGC	LPTPMQS	DEG_SCF_FBW7_1	785:791	Mutation rewiring degron network	0.25
p.R778L	DO233206	GACA	ICGC	LPTPMQS	DEG_SCF_FBW7_1	785:791	Mutation rewiring degron network	0.1389
p.G790V	DO228819	LICA	ICGC	LPTPMQS	DEG_SCF_FBW7_1	785:791	Mutation altering degron motif	0.7532
p.P716Q	DO229019	LICA	ICGC	VVSSS	DEG_SPOP_SBC_1	715:719	Mutation altering degron motif	0.7035
p.T779N	DO229028	LICA	ICGC	LPTPMQS	DEG_SCF_FBW7_1	785:791	Mutation rewiring degron network	0.1667
p.H604Y	DO229050	LICA	ICGC	PGTSS	DEG_SPOP_SBC_1	599:603	Mutation rewiring degron network	0.3056
p.P610L	DO222644	MELA	ICGC	PGTSS	DEG_SPOP_SBC_1	599:603	Mutation rewiring degron network	0.1389
p.S787F	DO222843	MELA	ICGC	LPTPMQS	DEG_SCF_FBW7_1	785:791	Mutation altering degron motif	0.7982
p.S704R	DO229257	THCA	ICGC	AKSSS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.2778
p.T694S	DO229208	THCA	ICGC	AKSSS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.2222
p.R705C	SIDM00620	Glioblastoma	GDSC	AKSSS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.25
p.R705C	SIDM00620	Glioblastoma	GDSC	VVSSS	DEG_SPOP_SBC_1	715:719	Mutation rewiring degron network	0.0556
p.R705C	SIDM01518	Oral Cavity Carcinoma	GDSC	AKSSS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.25
p.R705C	SIDM01518	Oral Cavity Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	715:719	Mutation rewiring degron network	0.0556
p.G611D	SIDM00193	Colorectal Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	599:603	Mutation rewiring degron network	0.1111
p.G611D	ACH-000991	Colon/Colorectal Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	599:603	Mutation rewiring degron network	0.1111
p.G611D	SNU-81	large intestine	COSMIC	PGTSS	DEG_SPOP_SBC_1	599:603	Mutation rewiring degron network	0.1111
p.T792A	SIDM00507	Other Solid Cancers	GDSC	LPTPMQS	DEG_SCF_FBW7_1	785:791	Mutation rewiring degron network	0.3056
p.T792A	ACH-001490	Lung Cancer	CCLE	LPTPMQS	DEG_SCF_FBW7_1	785:791	Mutation rewiring degron network	0.3056
p.T792A	COR-L321	NS	COSMIC	LPTPMQS	DEG_SCF_FBW7_1	785:791	Mutation rewiring degron network	0.3056
p.L786F	SIDM00523	Small Cell Lung Carcinoma	GDSC	LPTPMQS	DEG_SCF_FBW7_1	785:791	Mutation altering degron motif	0.6981
p.L786F	ACH-000698	Lung Cancer	CCLE	LPTPMQS	DEG_SCF_FBW7_1	785:791	Mutation altering degron motif	0.6981
p.L786F	DMS-53	lung	COSMIC	LPTPMQS	DEG_SCF_FBW7_1	785:791	Mutation altering degron motif	0.6981
p.A718T	SIDM00882	Breast Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	715:719	Mutation altering degron motif	0.7139
p.G727D	SIDM01059	Melanoma	GDSC	VVSSS	DEG_SPOP_SBC_1	715:719	Mutation rewiring degron network	0.1111
p.G727D	ACH-000915	Skin Cancer	CCLE	VVSSS	DEG_SPOP_SBC_1	715:719	Mutation rewiring degron network	0.1111
p.G727D	IPC-298	skin	COSMIC	VVSSS	DEG_SPOP_SBC_1	715:719	Mutation rewiring degron network	0.1111
p.S714P	ACH-000977	lymph node	CCLE	VVSSS	DEG_SPOP_SBC_1	715:719	Mutation rewiring degron network	0.3056
p.S714P	LNCaP-Clone-FGC	prostate	COSMIC	VVSSS	DEG_SPOP_SBC_1	715:719	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KANSL3

UniProt ID: Q9P2N6

Entrez ID: 55683

Protein name: KAT8 regulatory NSL complex subunit 3 (NSL complex protein NSL3) (Non-specific lethal 3 homolog) (Serum inhibited-related protein) (Testis development protein PRTD)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KANSL3 in