DegronMD

Uniprot ID: Q9P2N6

Source protein: KAT8 regulatory NSL complex subunit 3

Source gene: KANSL3

Class: DEG_SPOP_SBC_1

Location: 715:719

E3 ligase: SPOP

DEGRON score: 0.9927

ASA_SCORE: 84.5

COIL: 0.9326

CONS_SCORE: 0.389

DSS_SCORE: 0.4369

HELIX: 0.0252

FCONS_SCORE: 0.9258

RIG_SCORE: 0.653

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A708D	TCGA-D3-A2J8	SKCM	TCGA	VVSSS	DEG_SPOP_SBC_1	0.1389
p.A708D	DO37778	SKCM	ICGC	VVSSS	DEG_SPOP_SBC_1	0.1389
p.Q726E	TCGA-D8-A27L	BRCA	TCGA	VVSSS	DEG_SPOP_SBC_1	0.1389
p.Q726E	DO2180	BRCA	ICGC	VVSSS	DEG_SPOP_SBC_1	0.1389
p.P711S	TCGA-FW-A3TU	SKCM	TCGA	VVSSS	DEG_SPOP_SBC_1	0.2222
p.P711S	DO37441	SKCM	ICGC	VVSSS	DEG_SPOP_SBC_1	0.2222
p.P716Q	DO229019	LICA	ICGC	VVSSS	DEG_SPOP_SBC_1	0.7035
p.R705C	SIDM00620	Glioblastoma	GDSC	VVSSS	DEG_SPOP_SBC_1	0.0556
p.R705C	SIDM01518	Oral Cavity Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	0.0556
p.A718T	SIDM00882	Breast Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	0.7139
p.G727D	SIDM01059	Melanoma	GDSC	VVSSS	DEG_SPOP_SBC_1	0.1111
p.G727D	ACH-000915	Skin Cancer	CCLE	VVSSS	DEG_SPOP_SBC_1	0.1111
p.G727D	IPC-298	skin	COSMIC	VVSSS	DEG_SPOP_SBC_1	0.1111
p.S714P	ACH-000977	lymph_node	CCLE	VVSSS	DEG_SPOP_SBC_1	0.3056
p.S714P	LNCaP-Clone-FGC	prostate	COSMIC	VVSSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12035	Keratin, type II cytoskeletal 3	DEG_SPOP_SBC_1	525:529	VVSSS	SPOP	0.6552	More...
P41180	Extracellular calcium-sensing receptor	DEG_SPOP_SBC_1	1055:1059	VVSSS	SPOP	0.8121	More...
Q14525	Keratin, type I cuticular Ha3-II	DEG_SPOP_SBC_1	258:262	VVSSS	SPOP	0.5895	More...
Q5UIP0	Telomere-associated protein RIF1	DEG_SPOP_SBC_1	1196:1200	VVSSS	SPOP	0.8866	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	197:201	VVSSS	SPOP	0.913	More...
Q96JH7	Deubiquitinating protein VCPIP1	DEG_SPOP_SBC_1	1143:1147	VVSSS	SPOP	0.9956	More...
Q9H2K2	Poly [ADP-ribose] polymerase tankyrase-2	DEG_SPOP_SBC_1	854:858	VVSSS	SPOP	0.9829	More...
Q9P243	Zinc finger protein ZFAT	DEG_SPOP_SBC_1	581:585	VVSSS	SPOP	0.9599	More...
Q9P2N6	KAT8 regulatory NSL complex subunit 3	DEG_SPOP_SBC_1	715:719	VVSSS	SPOP	0.9927	More...
O60279	Sushi domain-containing protein 5	DEG_SPOP_SBC_1	362:366	VVSSS	SPOP	0.9462	More...
Q96K58	Zinc finger protein 668	DEG_SPOP_SBC_1	402:406	VVSSS	SPOP	0.9427	More...
Q9BQN1	Protein FAM83C	DEG_SPOP_SBC_1	376:380	VVSSS	SPOP	0.9887	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons