DegronMD

Uniprot ID: Q9BQN1

Source protein: Protein FAM83C

Source gene: FAM83C

Class: DEG_SPOP_SBC_1

Location: 376:380

E3 ligase: SPOP

DEGRON score: 0.9887

ASA_SCORE: 80.42

COIL: 0.9086

CONS_SCORE: 0.4864

DSS_SCORE: 0.6016

HELIX: 0.0702

FCONS_SCORE: 1.0371

RIG_SCORE: 0.6827

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P366L	TCGA-56-8083	LUSC	TCGA	VVSSS	DEG_SPOP_SBC_1	0.0556
p.P366L	DO223723	LUSC	ICGC	VVSSS	DEG_SPOP_SBC_1	0.0556
p.R385S	TCGA-BJ-A191	THCA	TCGA	VVSSS	DEG_SPOP_SBC_1	0.1944
p.R385S	DO40167	THCA	ICGC	VVSSS	DEG_SPOP_SBC_1	0.1944
p.S379L	TCGA-FW-A3R5	SKCM	TCGA	VVSSS	DEG_SPOP_SBC_1	0.7667
p.S379L	DO37406	SKCM	ICGC	VVSSS	DEG_SPOP_SBC_1	0.7667
p.R385C	SIDM02015	Colorectal Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	0.1944
p.R385H	SIDM00437	Acute Myeloid Leukemia	GDSC	VVSSS	DEG_SPOP_SBC_1	0.1944
p.R385H	SIDM00383	Gastric Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	0.1944
p.R385H	SIDM00368	Small Cell Lung Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	0.1944
p.R385H	SIDM01622	Breast Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	0.1944
p.R385H	ACH-001574	Leukemia	CCLE	VVSSS	DEG_SPOP_SBC_1	0.1944
p.R385H	SBC-5	lung	COSMIC	VVSSS	DEG_SPOP_SBC_1	0.1944
p.R385H	SCH	stomach	COSMIC	VVSSS	DEG_SPOP_SBC_1	0.1944
p.R385H	MOLM-13	haematopoietic_and_lymphoid_tissue	COSMIC	VVSSS	DEG_SPOP_SBC_1	0.1944
p.G369S	SIDM00449	B-Lymphoblastic Leukemia	GDSC	VVSSS	DEG_SPOP_SBC_1	0.1389
p.G369S	ACH-000922	Leukemia	CCLE	VVSSS	DEG_SPOP_SBC_1	0.1389
p.G369S	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	VVSSS	DEG_SPOP_SBC_1	0.1389
p.T374M	SIDM00192	Colorectal Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	0.2778
p.T374M	SIDM01368	Gastric Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	0.2778
p.T374M	SIDM01442	Glioma	GDSC	VVSSS	DEG_SPOP_SBC_1	0.2778
p.T374M	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	VVSSS	DEG_SPOP_SBC_1	0.2778
p.S379T	ACH-000975	Lung Cancer	CCLE	VVSSS	DEG_SPOP_SBC_1	0.6005
p.L381V	ACH-001393	Breast Cancer	CCLE	VVSSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12035	Keratin, type II cytoskeletal 3	DEG_SPOP_SBC_1	525:529	VVSSS	SPOP	0.6552	More...
P41180	Extracellular calcium-sensing receptor	DEG_SPOP_SBC_1	1055:1059	VVSSS	SPOP	0.8121	More...
Q14525	Keratin, type I cuticular Ha3-II	DEG_SPOP_SBC_1	258:262	VVSSS	SPOP	0.5895	More...
Q5UIP0	Telomere-associated protein RIF1	DEG_SPOP_SBC_1	1196:1200	VVSSS	SPOP	0.8866	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	197:201	VVSSS	SPOP	0.913	More...
Q96JH7	Deubiquitinating protein VCPIP1	DEG_SPOP_SBC_1	1143:1147	VVSSS	SPOP	0.9956	More...
Q9H2K2	Poly [ADP-ribose] polymerase tankyrase-2	DEG_SPOP_SBC_1	854:858	VVSSS	SPOP	0.9829	More...
Q9P243	Zinc finger protein ZFAT	DEG_SPOP_SBC_1	581:585	VVSSS	SPOP	0.9599	More...
Q9P2N6	KAT8 regulatory NSL complex subunit 3	DEG_SPOP_SBC_1	715:719	VVSSS	SPOP	0.9927	More...
O60279	Sushi domain-containing protein 5	DEG_SPOP_SBC_1	362:366	VVSSS	SPOP	0.9462	More...
Q96K58	Zinc finger protein 668	DEG_SPOP_SBC_1	402:406	VVSSS	SPOP	0.9427	More...
Q9BQN1	Protein FAM83C	DEG_SPOP_SBC_1	376:380	VVSSS	SPOP	0.9887	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VVSSS

Degron related mutations and impact score

Drug responses associated with FAM83C mutations

All proteins holding degron of VVSSS